Genetic diversity of longtail macaques (<i>Macaca fascicularis</i>) on the island of Mauritius: an assessment of nuclear and mitochondrial DNA polymorphisms

Kawamoto, Y.; Kawamoto, Shoichi; Matsubayashi, Kiyoaki; Nozawa, Ken; Watanabe, Tsuyoshi; Stanley, Marys-Ann; Perwitasari-Farajallah, Dyah

doi:10.1111/j.1600-0684.2007.00225.x

Cited by 46 publications

(62 citation statements)

References 28 publications

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“…The Mauritian animals, purportedly introduced from Java as recently as the seventeenth or eighteenth centuries Tattersall 1981, 1986), reflect strong founder effects by exhibiting approximately one fourth of all the alleles found in long-tailed macaques and in both macaque species, respectively. The low Mauritian diversity at STR (as observed in this study as well as that by Bonhomme et al 2008), MHC (Kawamoto et al 2008) and mtDNA ) loci and the absence of Y chromosomal variation Coke 2007, Kawamoto et al 2008) have been attributed to small founder representation and subsequent rapid population expansion , Kawamoto et al 2008, Bonhomme et al 2008. In contrast to the findings here that the Mauritian and Indonesian animals are indeed genetically distinct, Bonhomme et al (2008) and Kawamoto et al (2008) reported a higher degree of similarity between the Mauritian and Javan animals suggesting that the founders of the former population actually descend from Javanese ancestors.…”

Section: Discussionmentioning

confidence: 59%

Hybridization and Stratification of Nuclear Genetic Variation in Macaca mulatta and M. fascicularis

et al. 2008

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Genotypes for 13 short tandem repeats (STRs) were used to assess the genetic diversity within and differentiation among populations of rhesus macaques (Macaca mulatta) from mainland Asia and long-tailed macaques (M. fascicularis) from mainland and insular Southeast Asia. These animals were either recently captured in the wild or derived from wild-caught founders maintained in captivity for biomedical research.A large number of alleles is shared between the two macaque species but a significant genetic division between them persists. This distinction is more clear-cut among populations that are not, or are unlikely to have recently been, geographically contiguous. Our results suggest there has been significant interspecies nuclear gene flow between rhesus macaques and long-tailed macaques on the mainland. Comparisons of mainland and island populations of long-tailed macaques reflect marked genetic subdivisions due to barriers to migration. Geographic isolation has restricted gene flow, allowing island populations to become subdivided and genetically differentiated. Indonesian long-tailed macaques show evidence of long-term separation and genetic isolation from the mainland populations, while long-tailed macaques from the Philippines and Mauritius both display evidence of founder effects and subsequent isolation, with the impact from genetic drift being more profound in the latter.

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Section: Discussionmentioning

confidence: 59%

Hybridization and Stratification of Nuclear Genetic Variation in Macaca mulatta and M. fascicularis

et al. 2008

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“…Distilled water as a vehicle control or the EGME solution (300 mg/kg) at a volume of 5 mL/kg was administered orally to 3 males each for 4 consecutive days. To minimize the genetic diversity related to the different origin (Kawamoto et al, 2008;Higashino et al, 2012), monkeys from both Indonesian and Chinese origins were assigned to each group. The first day of the dosing period was designated as day 1.…”

Section: Experimental Protocolmentioning

confidence: 99%

MicroRNA profling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model

et al. 2015

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-To establish and characterize ethylene glycol monomethyl ether (EGME)-induced testicular toxicity model in cynomolgus monkeys, EGME at 0 or 300 mg/kg was administered orally to sexually mature male cynomolgus monkeys (n = 3/group) for 4 consecutive days. Circulating and testicular micro-RNA (miRNA) profiles in this model were investigated using miRNA microarray or real-time quantitative reverse transcription-PCR methods. EGME at 300 mg/kg induced testicular toxicity in all the monkeys, which was characterized histopathologically by decreases in pachytene spermatocytes and round spermatids, without any severe changes in general conditions or clinical pathology. In microarray analysis, 16 down-regulated and 347 up-regulated miRNAs were detected in the testis, and 326 down-regulated but no up-regulated miRNAs were detected in plasma. Interestingly, miR-1228 and miR-2861 were identified as abundant miRNAs in plasma and the testis of control animals, associated presumably with apoptosis and cell differentiation, respectively, and were prominently increased in the testis of EGME-treated animals, reflecting the recovery from EGME-induced testicular damages via stimulating cell proliferation and differentiation of sperm. Furthermore, down-regulation of miR-34b-5p and miR-449a, which are enriched in meiotic cells like pachytene spermatocytes, was obvious in the testis, suggesting that these spermatogenic cells were damaged by the EGME treatment. In conclusion, EGME-induced testicular toxicity in cynomolgus monkeys was shown, and this model would be useful for investigating the mechanism of EGME-induced testicular toxicity and identifying testicular biomarkers. Additionally, testicular miR-34b-5p and miR-449a were suggested to be involved in damage of pachytene spermatocytes.

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“…As an important genetic marker, maternally-inherited mitochondrial DNA (mtDNA) warrants special attention for genetic investigations such as intraspecies variation [35], population structure [10,12,13,20,34], phylo-, population structure [10,12,13,20,34], phylo- [10,12,13,20,34], phylo-, phylogeography [5,23,26,37], and demography [24] in ma- [5,23,26,37], and demography [24] in ma-, and demography [24] in ma- [24] in main macaque species. In particular, the mtDNA control (D-loop) region is composed of �00 to 1,000 base pairs (bp) and contains hypervariable segments 1 (HVI) and 2 (HVII).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA Diversity among Three Subpopulations of Cynomolgus Macaques (Macaca fascicularis) Originating from the Indochinese Region

et al. 2010

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Abstract:The cynomolgus macaque (Macaca fascicularis) has emerged as an important experimental animal model for biomedical research in various domains, necessitating the more extensive characterization of the genetic backgrounds influencing the macaque's response to drugs and sensitivity to experimental disease. The diversity of the variable mitochondrial DNA (mtDNA) D-loop region has been analyzed phylogenetically among geographically isolated populations or within subdivisions of the same regional population. However, the genetic differences among several substructures originating from a common population have not yet been investigated. By sequencing fragments of the mtDNA D-loop region from two subpopulations from the Indochinese region (Cambodian-Chinese and Vietnamese) along with two native Indonesian and Filipino populations, we identified 87 mtDNA D-loop haplotypes, of which 67 are new. The phylogenetic relationship suggests that the Indochinese haplotypes are intermingled in comparison to the distinct divergence of the Indonesian and Filipino lineages. The subpopulations were shown by estimation of evolutionary divergence and Wright's F-statistic (Fst) to have little genetic differentiation. Altogether, the subpopulations may be used in biomedical research, even though a slight difference is observed in haplotype frequencies among them. Therefore, genetic diversity analyses will be necessary for the elucidation of genetic differences among the populations, as well as to obtain a better understanding of genetic diversity for biomedical research. This will involve the selection of macaques and the monitoring of genetic heterogeneity among and within breeding facilities.

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Genetic diversity of longtail macaques (Macaca fascicularis) on the island of Mauritius: an assessment of nuclear and mitochondrial DNA polymorphisms

Cited by 46 publications

References 28 publications

Hybridization and Stratification of Nuclear Genetic Variation in Macaca mulatta and M. fascicularis

Hybridization and Stratification of Nuclear Genetic Variation in Macaca mulatta and M. fascicularis

MicroRNA profling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model

Mitochondrial DNA Diversity among Three Subpopulations of Cynomolgus Macaques (Macaca fascicularis) Originating from the Indochinese Region

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