Genetic Diversity of Insulin Resistance and Metabolic Syndrome

Abstract

A key in the etiology of a cluster of metabolic syndrome such as hyperglycemia, dyslipidemia, and obesity is known for insulin resistance, which is becoming a major global public health problem. Extensive studies have revealed many genetic factors for both insulin resistance and the components of metabolic syndrome. Advanced modern genotyping methods including genome-wide association studies and next-generation sequencing have allowed for the identification of both common and rare genetic variants related to these chronic disease-associated traits. Multiple genotype–phenotype studies are also needed to identify new and accurate genetic biomarkers in these conditions. The purpose of this chapter is to present genetic variants related to the pathogenesis of metabolic syndrome and insulin resistance and is to review the relevance between insulin resistance and metabolic syndrome clusters in terms of genetic diversity.

An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches

“…These increase with ageing, by taking medicines which increase weight gain, by mitochondrial and endocrine dysfunctions, and genetic predisposition [3]. Although not the focus of the current review, the later findings on the genetic basis of MS have greatly contributed to further understanding the different underlying mechanisms and phenotypes of MS [5][6][7].…”