Genetic Diversity of Circulating Foot and Mouth Disease Virus in Uganda Cross-Sectional Study During 2014–2017

Velazquez‐Salinas, Lauro; Mwiine, Frank Norbert; Ahmed, Zaheer; Ochwo, Sylvester; Munsey, Anna; Lutwama, Julius J.; Pérez, Andrés; VanderWaal, Kimberly; Rieder, Elizabeth

doi:10.3389/fvets.2020.00162

Cited by 7 publications

(13 citation statements)

References 28 publications

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“…Sequences collected from northern Uganda at the end of the study period in 2017 cluster with FMDV circulating in Ethiopia and Kenya in 2005 and 2010, respectively. Details on the topotype classification of sequences collected during this study have been previously described (Mwiine et al, 2019; Velazquez‐Salinas et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…The study was approved by Uganda Institutional Animal Ethics Review Committee (SBLS/REC/13/016), Makarere University. The cross‐sectional study has been previously described in Mwiine et al (2019), Munsey et al (2019), and Velazquez‐Salinas et al (2020).…”

Section: Methodsmentioning

confidence: 99%

“…Sequencing was performed at Plum Island Animal Disease Center as previously described (Mwiine et al, 2019). FMDV serotype O VP1 sequences generated as part of this study ( n = 175) (Mwiine et al, 2019; Velazquez‐Salinas et al, 2020) were combined with GenBank sequences ( n = 386), which were selected using the NIAID Virus Pathogen Database and Analysis Resource (ViPR, http://www.viprbrc.org/) (Pickett et al, 2012). GenBank isolates which met all the following criteria were considered: (i) had a known isolation year, (ii) collected in Africa, and (iii) had a known isolation location to at least the level of subnational administrative unit.…”

Section: Methodsmentioning

confidence: 99%

“…FMDV sequences collected for this study: see Velazquez‐Salinas et al (2020) (https://doi.org/10.3389/fvets.2020.00162) and Table .…”

Section: Data Availability Statementmentioning

confidence: 99%

“…Here, we use “lineage” in the generic sense, that is, sharing a common ancestor, not in reference to FMDV‐specific nomenclature. A large repository of recent serotype O VP1 sequences available from our nationwide Uganda study (Mwiine et al, 2019; Velazquez‐Salinas et al, 2020) offers unique opportunities to examine drivers of transmission due to the relatively fine‐scale resolution of sequences, thus improving our understanding of regional transmission patterns in an endemic setting.…”

Section: Introductionmentioning

confidence: 99%

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Phylogeographic analysis of foot‐and‐mouth disease virus serotype O dispersal and associated drivers in East Africa

et al. 2021

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The continued endemicity of foot and mouth disease virus (FMDV) in East Africa has significant implications for livestock production and poverty reduction, yet its complex epidemiology in endemic settings remains poorly understood. Identifying FMDV dispersal routes and drivers of transmission is key to improved control strategies. Environmental heterogeneity and anthropogenic drivers (e.g., demand for animal products) can impact viral spread by influencing host movements. Here, we utilized FMDV serotype O VP1 genetic sequences and corresponding spatiotemporal data in order to (i) infer the recent dispersal history, and (II) investigate the impact of external factors (cattle density, human population density, proximity to livestock markets, and drought) on dispersal velocity, location, and direction of FMDV serotype O in East Africa. We identified statistical evidence of long-distance transmission events, and we found that FMDV serotype O tends to remain circulating in areas of high cattle density, high human population density, and in close proximity to livestock markets. The latter two findings highlight the influence of anthropogenic factors on FMDV serotype O spread in this region. These findings contribute to the understanding of FMDV epidemiology in East Africa and can help guide improved control measures.

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Section: Resultsmentioning

confidence: 99%