Genetic diversity and persistent transmission of norovirus in Shenzhen, China, 2016–2018

Hu, Xiaofeng; He, Yaqing; Jin, Yunlong; Xu, Bin; Shao, Chen; Liu, Kangkang; Jin, Lianqun; Zhang, Chuanfu; Liang, Shengnan; Hu, Mingda; Zhang, Hailong; Tian, Sai; Yang, Hong; Xiao, Yong; Song, Hongbin; Ren, Hongguang; Qiu, Shaofu

doi:10.1016/j.jinf.2022.01.018

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“…36 Our previous research has investigated the genetic diversity, epidemiology, phylogeny, and transmission of noroviruses circulating in Shenzhen, China. 37 However, compared with noroviruses and rotaviruses which have been extensively studied,…”

Section: Discussionmentioning

confidence: 99%

“…While noroviruses pose a threat to all age groups, rotaviruses and astroviruses are more common in infants and children 36 . Our previous research has investigated the genetic diversity, epidemiology, phylogeny, and transmission of noroviruses circulating in Shenzhen, China 37 . However, compared with noroviruses and rotaviruses which have been extensively studied, HAstV remains one of the least investigated enteric viruses.…”

Section: Discussionmentioning

confidence: 99%

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Genetic characteristics of classical astroviruses in Shenzhen, China, 2016–2019

Hu,

Wang,

et al. 2023

Journal of Medical Virology

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Human astrovirus (HAstV) is a single‐stranded, positive‐sense RNA virus and is the leading cause of viral gastroenteritis. However, despite its prevalence, astroviruses still remain one of the least studied enteroviruses. In this study, we sequenced 11 classical astrovirus strains from clinical samples collected in Shenzhen, China from 2016 to 2019, analyzed their genetic characteristics, and deposited them into GenBank. We conducted phylogenetic analysis using IQ‐TREE software, with references to astrovirus sequences worldwide. The phylogeographic analysis was performed using the Bayesian Evolutionary Analysis Sampling Trees program, through Bayesian Markov Chain Monte Carlo sampling. We also conducted recombination analysis with the Recombination Detection Program. The newly sequenced strains were categorized as HAstV genotype 1, which is the predominant genotype in Shenzhen. Phylogeographic reconstruction indicated that HAstV‐1 may have migrated from the United States to China, followed by frequent transmission between China and Japan. The recombination analysis revealed recombination events within and across genotypes, and identified a recombination‐prone region that produced relatively uniform recombination breakpoints and fragment lengths. The genetic analysis of HAstV strains in Shenzhen addresses the current lack of astrovirus data in the region of Shenzhen and provides key insights to the evolution and transmission of astroviruses worldwide. These findings highlight the importance of improving surveillance of astroviruses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%