2000
DOI: 10.1086/315780
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Genetic Diversity and Molecular Epidemiology of Norwalk‐Like Viruses

Abstract: Specimens (n=287) from 59 gastroenteritis outbreaks collected from February 1997 to March 1999 were analyzed by reverse transcriptase-polymerase chain reaction. The majority of outbreaks (88%) were associated with Norwalk-like viruses. Molecular analyses of strains from 46 outbreaks showed the cocirculation during the 1998-1999 winter of 2 genogroup II clusters, accounting for 57% and 28% of outbreaks, respectively. An important genetic diversity was observed during this 2-year period. Thirteen different genog… Show more

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Cited by 33 publications
(26 citation statements)
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“…Our findings that NLV genogroup II strains were the dominant type (identified in 94% of positive specimens) is in agreement with those of previous studies of NLV infections in pediatric populations in France, Finland, and Canada (1,4,9). Most genogroup II strains identified in our study (84%) belonged to the Lordsdale cluster, which has a worldwide distribution and is prominent in many countries, including Australia, the United States, and Canada (2, 4, 13).…”
supporting
confidence: 93%
See 1 more Smart Citation
“…Our findings that NLV genogroup II strains were the dominant type (identified in 94% of positive specimens) is in agreement with those of previous studies of NLV infections in pediatric populations in France, Finland, and Canada (1,4,9). Most genogroup II strains identified in our study (84%) belonged to the Lordsdale cluster, which has a worldwide distribution and is prominent in many countries, including Australia, the United States, and Canada (2, 4, 13).…”
supporting
confidence: 93%
“…Our study shows good agreement with previous surveys of the incidence of calicivirus infection in children hospitalized with acute gastroenteritis in France, China, and South Africa (1,11,12). In comparison, surveillance studies of young children with mild diarrhea from community or outbreak settings detected calicivirus in 19 to 88% of such cases in various countries, including Finland, Canada, and Mexico (3,4,9,10). …”
supporting
confidence: 91%
“…Based on the amino acid sequence of the complete VP1 gene, NoVs can be classified into five genogroups and at least 32 genotypes (8 in GI. [1][2][3][4][5][6][7][8]19 in GII, 2 in GIII, 2 in GIV, and 1 in GV) (19,31,33). However, since several genotypes (e.g., GI.6) form distinct clusters at the nucleotide level, further standardization based on partial nucleotide sequences awaits international agreement.…”
Section: Discussionmentioning
confidence: 99%
“…Currently, classification of NoV genotypes is based on genetic diversity within the entire capsid gene (2,16,33). However, most laboratories sequence a small region (200 to 344 bp) of either the polymerase (regions A and B) or major capsid (VP1; regions C, D, and E) gene (1,2,8,14,21,27,28) to genotype strains (Fig. 1).…”
mentioning
confidence: 99%
“…In addition, primers directed to other regions of the Norovirus genome have been developed including relatively conserved regions at the 3'-end of ORF1 (region B 24,25,26 ), at the 5'-end of ORF2 (region C and E; 18,27,28 ) and at the 3' end of ORF2 (region D 29 ) (Figure 4). Real-time PCR systems are excellent diagnostic tools; they are more specific and sensitive than traditional PCRs.…”
Section: I63 Molecular Biological Techniquesmentioning
confidence: 99%