Genetic diversity and haplotype structure of 24 Y‐chromosomal STR in Chinese Hui ethnic group and its genetic relationships with other populations

Abstract

In the present study, 24 Y-chromosomal short tandem repeat (Y-STR) loci were analyzed in 115 unrelated Hui male individuals from Haiyuan county or Tongxin county, Ningxia Hui Autonomous Region, China, to evaluate the forensic application of the 24 STR loci and to analyze interpopulation differentiations by making comparisons between the Hui group data and previously published data of other 13 populations. A total of 115 different haplotypes were observed on these 24 Y-STR loci. The gene diversities ranged from 0.4049 (DYS437) to 0.9729 (DYS385a, b). The overall haplotype diversity was 1 at AGCU 24 Y-STR loci level, while the values were reduced to 0.999237, 0.996949, and 0.996644 at the Y-filer 17 loci, 11 Y-STR loci of extended haplotype and 9 Y-STR loci of minimal haplotype levels, respectively; whereas, haplotype diversity for additional 7 loci (not included in Y-filer 17 loci) was 0.995271. The pairwise FST , multidimensional scaling plot and neighbor-joining tree indicated the Hui group had the closest genetic relationship with Sala in the paternal lineage in the present study. In summary, the results in our study indicated the 24 Y-STRs had a high level of polymorphism in Hui group and hence could be a powerful tool for forensic application and population genetic study.

RETRACTED: Forensic characteristics and genetic affinity analyses of Xinjiang Mongolian group using a novel six fluorescent dye‐labeled typing system including 41 Y‐STRs and 3 Y‐InDels

“…Match probability (MP) is computed with computational formula as MP = ∑ p i 2 . Discrimination capacity (DC) is the ratio of total number of distinct haplotypes to the sample size (Zhu et al, ). Furthermore, in order to measure the effect of the newly added loci, forensic parameters of XJM group, such as GD, MP and DC in the newly added loci and five different haplotype sets (AmpFLSTR ® Yfiler ® kit, Promega PowerPlex ® Y23 kit, AmpFLSTR ® Yfiler ® Plus kit, YHRD Maximal, and the kit under investigation) were compared.…”

Haplotype analysis of the polymorphic 40 Y-STR markers in Chinese populations

“…Another Y-STR typing kit, GFS Y24, includes 3 Yfiler loci (DYS635 and DYS385a/b), with 21 additional Y-STR loci (DYS531, DYS630, DYS622, DYS552, DYS510, DYS449, DYS459a/b, DYS446, DYS443, DYS587, DYS527a/b, DYS460, Y-GATA-A10, DYS520, DYS557, DYS522, DYS481, DYS570 and DYS444). Previous studies indicated that the additional loci included in these two typing kits have a high level of polymorphisms in Chinese populations [8,10]. In the present study, we investigated haplotype data at the 40 Y-STR loci level of 1128 unrelated male individuals from the following six Chinese ethnic populations: Han (n = 300), Hui (n = 244), Korean (n = 100), Mongolian (n = 100), Uighur (n = 284) and Tibetan (n = 100), using the AGCU Y24 and GFS Y24 STR typing systems (eight loci, DYS449, DYS635, DYS527a/b, DYS522 and DYS444, common to both systems).…”

“…In recent years, a number of multiplex Y-STR genotyping systems have been developed by several domestic researching groups based on the population data of the Chinese community [8][9][10]. The AGCU Y24 is a domestic Y-STR amplification system that includes Yfiler 17 loci and 7 additional Y-STR loci, five single-copy loci (DYS449, DYS447, DYS522, DYS388 and DYS444) and one multi-copy locus (DYS527a/b).…”

Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups

“…At present, short tandem repeats (STRs) are widely used in forensic cases for paternity testing and individual identification in worldwide forensic DNA laboratories 1 2 3 4 . The universal use of STRs leads to the establishment of well constructed forensic DNA databases and development of simple typing methodologies.…”