Genetic Diversity and Evolutionary Features of type VI Secretion Systems in
            <i>Salmonella</i>

Bao, Hongchu; Zhao, Jinyan; Zhu, Songling; Wang, Shuang; Zhang, Jianjuan; Wang, Xiaoyu; Han, Bing; Liu, Chang; Liu, Huidi; Liu, Shulin

doi:10.2217/fmb-2018-0260

Cited by 19 publications

(9 citation statements)

References 45 publications

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“…In Salmonella enterica, T6SS gene clusters are encoded within different pathogenicity islands (SPIs), depending on the subspecies and serovar (Blondel et al, 2009;Bao et al, 2019). S. enterica subsp.…”

Section: Introductionmentioning

confidence: 99%

A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan

et al. 2020

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Section: Introductionmentioning

confidence: 99%

A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan

et al. 2020

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“…Typhimurium, 26 more similar to SPI-19 of S. enterica subsp. salamae ST114 (an in silico analysis), 38 thereby a new SPI-19 type found in Salmonella . The antibacterial activity assay revealed that S .…”

Section: Discussionmentioning

confidence: 99%

Salmonella enterica subsp. II serovar 4,5,12:a:- may cause gastroenteritis infections in humans

et al. 2022

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Some serovars of Salmonella are not or rare found to cause salmonellosis in human. In our clinic-based surveillance, three rare Salmonella 4,5,12:a:- strains were recovered from three patients with diarrhea. To explore their genetic and epidemiological characteristics and pathogenesis, we conducted whole-genome sequencing, in vitro invasion assays in mammalian cells, and in vivo virulence assays in an animal model. The three isolates had indistinguishable molecular patterns and similar genome sequences, and clustered together with an isolate from edible fish traded among countries. The isolates had biochemical reactions identical with those of Salmonella subspecies enterica but belonged to subspecies salamae according to genome phylogeny, revealing a new serovar, S. enterica subsp. II serovar 4,5,12:a:-. The strains contained multiple virulence genes, elicited temporary bacteremia and enteritidis and caused cell damage in the mouse liver and cecum. This study provides evidence that this new Salmonella salamae serovar can infect humans and cause clusters of cases, and whole-genome sequencing detection and surveillance of Salmonella can help to accurately define Salmonella classification and clonality, improve diagnosis, facilitate outbreak detection and aid in the source tracing of salmonellosis epidemics.

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“…T6SSs are widespread among Salmonella spp. and are encoded in different SPIs (SPI-6, SPI-19, SPI-20, SPI-21, SPI-22) [194,195]. Only two SPI-6 T6SS antibacterial effectors have been characterized to date: Tae4 (type VI amidase effector 4) and Tlde1 (type VI L,D-transpeptidase effector 1), both effectors target the peptidoglycan of competitors by different mechanisms [196,197].…”

Section: Class I Microcins Include Mccb17 [162] Mccc7-c51 [163] and M...mentioning

confidence: 99%

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

et al. 2021

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A commensal microbial community is established in the mammalian gut during its development, and these organisms protect the host against pathogenic invaders. The hallmark of noninvasive Salmonella gut infection is the induction of inflammation via effector proteins secreted by the type III secretion system, which modulate host responses to create a new niche in which the pathogen can overcome the colonization resistance imposed by the microbiota. Several studies have shown that endogenous microbes are important to control Salmonella infection by competing for resources. However, there is limited information about antimicrobial mechanisms used by commensals and pathogens during these in vivo disputes for niche control. This review aims to revisit the steps that Salmonella needs to overcome during gut colonization—before and after the induction of inflammation—to achieve an effective infection. We focus on a series of reported and hypothetical antagonistic interbacterial interactions in which both contact‐independent and contact‐dependent mechanisms might define the outcome of the infection.

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Genetic Diversity and Evolutionary Features of type VI Secretion Systems in Salmonella

Cited by 19 publications

References 45 publications

A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan

A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan

Salmonella enterica subsp. II serovar 4,5,12:a:- may cause gastroenteritis infections in humans

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

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