Genetic Diversity and Complexity of Plasmodium Falciparum Infections in Lagos, Nigeria

Abstract

Background: Genetic diversity in Plasmodium falciparum populations is of major importance in the outcome of antimalarial drug trialsand vaccine design. Merozoite surface protein-1 (msp 1) and msp 2 are well known antigenic markers for distinguishing persistent and new infections with P. falciparum.

Prevalence and genetic diversity of Plasmodium falciparum in patients attending regional health center in Daloa, Cte dIvoire

“…This allelic polymorphism is similar to that obtained in Burkina Faso (Soulama et al, 2009) with 41 alleles and differs from that obtained in Gabon (Bouyou-Akotet et al, 2015) with 25 alleles and in Mauritania (Ahmedou- Salem et al, 2014) with 27 alleles. The polymorphic variation of P. falciparum msp-1 gene could also be related to climate variations in the different epidemiological facies (Oyebola et al, 2014) and represent a constraint for vaccine development (Khaminsou et al, 2011). All the expected family profiles of msp-1 gene are found in this study with a predominance of Ro33 family.…”

“…Some authors have shown that this genetic diversity can vary from one region to another within the same country because of climate variability (Oyebola et al, 2014). Thus, in the context of control and emphasizing the elimination of malaria, it would be important to document the genetic diversity and characteristics of P. falciparum strains at regional level regarding particular epidemiological facies.…”

Genetic Diversity in Merozoite Surface Protein.1 of Plasmodium falciparum in Highlands: Wamena Papua Indonesia

“…1). In contrast with previous study in Brazil, Myamnar, Thailand and West Sumatera, where the highest frequency is mono allele (Atroosh et al, 2011;Kolawole et al, 2016;Khaminsou et al, 2011;Oyebola et al, 2014;Mohammed et al, 2015). According to Oyebola et al (2014) areas with high malaria spread generally have high parasite diversity with multi allele or polyclonal character.…”

Genetic Diversity and Population Structure of Plasmodium Falciparum in Nigeria: Insights From Microsatellites Loci Analysis

“…Although the incidence of malaria infections and malaria-associated mortality has reduced in many African countries [1,2,3], transmission continues in endemic regions despite intensi ed efforts towards prevention, control and eradication [4,5]. This is due, in part, to the high genetic diversity of Plasmodium falciparum that contributes to increased transmission rate and spread of resistant parasites [6]. Therefore, understanding the extent of genetic diversity, transmission intensity, and parasite population structure in Nigeria -the most malaria burdened country, is essential if the goal of malaria control or elimination is to be achieved.…”

“…Early molecular studies focused mostly on the use of polymorphic markers such as merozoite surface protein 1 (msp-1) and merozoite surface protein 2 (msp-2) and glutamate-rich protein (Glurp) to characterise falciparum genetic diversity and structure in Nigeria [7,8,9]. These markers were also useful in monitoring drug e cacy with regards to classi cation of recurrent falciparum parasitaemia as re-infection or recrudescent infection [6,10,11]. However, there have been contrasting reports of polymorphisms in msp-1 and msp-2 in earlier studies in Nigeria [6,12,13,14] which is associated with the fact that these antigenic markers are often under intense immune pressure [15,16,17].…”