Genetic Dissection of Complex Traits: From Functional Mapping to Systems Mapping

Wang, Yaqun

doi:10.4172/2155-6180.1000e119

Cited by 2 publications

(2 citation statements)

References 36 publications

(26 reference statements)

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“…2A. After a significant QTL is detected, systems mapping provide an elegant procedure to test mechanistic hypotheses of biological relevance [151]. They include:

Size-shape relationship: Given the ODE parameters for system (6), one can see how much biomass has been allocated to the leaves, stem, branches, roots and root hairs.

…”

Section: Developmental Dissection Of Complex Traitsmentioning

confidence: 99%

Mapping complex traits as a dynamic system

Sun

2015

Physics of Life Reviews

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Despite increasing emphasis on the genetic study of quantitative traits, we are still far from being able to chart a clear picture of their genetic architecture, given an inherent complexity involved in trait formation. A competing theory for studying such complex traits has emerged by viewing their phenotypic formation as a “system” in which a high-dimensional group of interconnected components act and interact across different levels of biological organization from molecules through cells to whole organisms. This system is initiated by a machinery of DNA sequences that regulate a cascade of biochemical pathways to synthesize endophenotypes and further assemble these endophenotypes toward the end-point phenotype in virtue of various developmental changes. This review focuses on a conceptual framework for genetic mapping of complex traits by which to delineate the underlying components, interactions and mechanisms that govern the system according to biological principles and understand how these components function synergistically under the control of quantitative trait loci (QTLs) to comprise a unified whole. This framework is built by a system of differential equations that quantifies how alterations of different components lead to the global change of trait development and function, and provides a quantitative and testable platform for assessing the multiscale interplay between QTLs and development. The method will enable geneticists to shed light on the genetic complexity of any biological system and predict, alter or engineer its physiological and pathological states.

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“…2A. After a significant QTL is detected, systems mapping provide an elegant procedure to test mechanistic hypotheses of biological relevance [151]. They include:

Size-shape relationship: Given the ODE parameters for system (6), one can see how much biomass has been allocated to the leaves, stem, branches, roots and root hairs.

…”

Section: Developmental Dissection Of Complex Traitsmentioning

confidence: 99%

Mapping complex traits as a dynamic system

Sun

2015

Physics of Life Reviews

View full text Add to dashboard Cite

show abstract

“…Surprisingly, little attention has been paid to the developmental dissection of the phenotype in quantitative genetics [10]. Traditional mapping studies associate DNA markers directly with the end-point phenotype of a complex trait without considering the process of trait formation.…”

mentioning

confidence: 99%

Toward the practical utility of systems mapping

Sun

2015

Physics of Life Reviews

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Genetic Dissection of Complex Traits: From Functional Mapping to Systems Mapping

Cited by 2 publications

References 36 publications

Mapping complex traits as a dynamic system

Mapping complex traits as a dynamic system

Toward the practical utility of systems mapping

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