Genetic Disorders Among Jews from Arab Countries

Dagan, Efrat; Gershoni‐Baruch, Ruth

doi:10.1007/978-3-642-05080-0_23

Cited by 1 publication

(1 citation statement)

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“…Syrian and Iranian Jews are genetically quite similar (Atzmon et al, 2010), yet unlike disease‐causing variants common to Iranian Jews (Dagan & Gershoni‐Baruch, 2010), much information is lacking regarding the frequency of pathogenic variants in Syrian Jews. Hence, we chose Iranian Jews as a comparison group for the assessment of allele frequencies within the Syrian Jewish population.…”

Section: Introductionmentioning

confidence: 99%

Recommendation of premarital genetic screening in the Syrian Jewish community based on mutation carrier frequencies within Syrian Jewish cohorts

Zeevi

Chung

Levi

et al. 2021

Molec Gen & Gen Med

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Background There is a paucity of information available regarding the carrier frequency for autosomal recessive pathogenic variants among Syrian Jews. This report provides data to support carrier screening for a group of autosomal recessive conditions among Syrian Jews based on the population frequency of 40 different pathogenic variants in a cohort of over 3800 individuals with Syrian Jewish ancestry. Methods High throughput PCR amplicon sequencing was used to genotype 40 disease‐causing variants in 3840 and 5279 individuals of Syrian and Iranian Jewish ancestry, respectively. These data were compared with Ashkenazi Jewish carrier frequencies for the same variants, based on roughly 370,000 Ashkenazi Jewish individuals in the Dor Yeshorim database. Results Carrier screening identified pathogenic variants shared among Syrian, Iranian, and Ashkenazi Jewish groups. In addition, alleles unique to each group were identified. Importantly, 8.2% of 3401 individuals of mixed Syrian Jewish ancestry were carriers for at least one pathogenic variant. Conclusion The findings of this study support the clinical usefulness of premarital genetic screening for individuals with Syrian Jewish ancestry to reduce the incidence of autosomal recessive disease among persons with Syrian Jewish heritage.

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Section: Introductionmentioning

confidence: 99%