Genetic differences in the avoidance conditioning of mice.

Royce, Joseph R.; Covington, Martin V.

doi:10.1037/h0040220

Cited by 74 publications

(21 citation statements)

References 4 publications

(1 reference statement)

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“…Numerous experiments have provided evidence for genetic differences in avoidance learning ability in mice. Comparisons of inbred strains have been reported using shuttle (Royce and Covington, 1960;Bovet et al, 1966), jump-up (Schlesinger and Wimer, 1967), and wheel-turn (Zerbolio, 1967) avoidance training procedures; all experimenters observed large strain differences. Shuttle avoidance learning has been studied with the methods of the diallel cross (Collins, 1964) and selective breeding (Bovet et al, 1969) as well.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and genetic relations between initial response to electric shock and rate of avoidance learning in mice

Wahłsten

1972

Behav Genet

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The first experiment was designed to determine what proportion of the between-strain variation in rate of avoidance learning could be attributed to strain differences in sensitivity and response topography to electric shock. Measures of jumping at six shock intensities for four inbred strains were collected in a pretest of shock sensitivity. They were then used to derive a shock intensity for each strain which yielded the same amount of jumping for all strains. Avoidance training was administered to other mice of the same age and strains using the same apparatus and shock source as in the pretest. When training was given with a 180 pa shock, significant strain differences were observed in latency of the first escape and total errors to a learning criterion during both jump-out and one-way avoidance training. A large strain by training procedure interaction was found, as well. When training was administered with shock levels which yielded equal jumping in the pretest, strain differences in latency of the first escape were totally eliminated. However, the magnitude of strain differences in the rate of avoidance learning was not changed substantially. A second experiment examined two F 1 hybrid strains and a four-way cross of the inbred strains tested in the first experiment. Results indicated that initial response to shock is characterized by intermediate inheritance, while rate of avoidance learning exhibits significant dominant inheritance. Although significant genetic differences in both initial response to shock and rate of avoidance learning were detected in the present experiments, it is concluded that the former cannot account for the latter.

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Section: Introductionmentioning

confidence: 99%

Phenotypic and genetic relations between initial response to electric shock and rate of avoidance learning in mice

Wahłsten

1972

Behav Genet

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“…A number of investigators have reported differences in avoidance performance among inbred mouse strains (e.g., Carran, Yeudall, & Royce, 1964;Royce & Covington, 1960;Schlesinger & Wimer, 1967;Wimer, Wymington, Farmer, & Schwartzkroin, 1968). Evidence that at least some aspects of avoidance performance could be under single-gene control has been obtained in at least three laboratories (Oliverio, Eleftheriou, & Bailey, 1973;Royce, Yeudall, & Poley, 1971;Sprott, 1972).…”

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confidence: 99%

Active- and passive-avoidance learning in inbred mice: Transfer of training effects

Sprott

Stavnes

1974

Animal Learning & Behavior

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“…In the first experiment, magnesium pemoline was found to have a detrimental effect on learning. As C3H is generally found to be a fast-conditioning sfram (Royce & Covington, 1960), it was hypothesized that the learning ceiling (as determined by a genetic mechanism) was too low, and the drug could not manifest its possible facilitating effect on learning. This experiment employed a slow-conditioning strain of mice (ST/bJ), with intermediate dosages of 8 and 16 mg/kg of magnesium pemoline.…”

Section: Methodsmentioning

confidence: 99%

Effect of magnesium pemoline on avoidance conditioning and intertrial activity in two strains of inbred mice

1969

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Magnesium pemoline was found to have a differential effect on behavior depending upon genotype. The drug resulted in increased activity and reduced avoidance scores for the fast-conditioning C3H strain of mice, whereas it significantly increased avoidance scores and activity for the slow-conditioning ST/bl strain. The effect of magnesium pemoline on behavior is discussed in terms of an inverted-U relationship between reactivity and learning.

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Genetic differences in the avoidance conditioning of mice.

Cited by 74 publications

References 4 publications

Phenotypic and genetic relations between initial response to electric shock and rate of avoidance learning in mice

Phenotypic and genetic relations between initial response to electric shock and rate of avoidance learning in mice

Active- and passive-avoidance learning in inbred mice: Transfer of training effects

Effect of magnesium pemoline on avoidance conditioning and intertrial activity in two strains of inbred mice

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