Genetic Determination of Bronchopulmonary Dysplasia Formation: Pros and Cons

Пожарищенская, В. К.; Давыдова, И. В.; Савостьянов, К. В.; Намазова-Баранова, Л. С.; Павлинова, Е. Б.; Пушков, А. А.

doi:10.15690/pf.v14i1.1698

Cited by 4 publications

(2 citation statements)

References 85 publications

(108 reference statements)

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“…This genotype leads to an increase in the level of MMP which affects the activity of inflammation, the degradation of collagen with the involvement of the neutrophils of inflammation. [1,2]. Based on the above, the analysis of polymorphism of the metalloproteinase 9 rs3918242435 gene is useful for predicting the course of bronchopulmonary dysplasia in premature infants and the formation of a personalized approach to their treatment.…”

Section: O N C L U S I O Nmentioning

confidence: 99%

“…In recent years, many studies on the genetic basis of bronchial diseases in children proved the participation of hereditary factors in the development of the disease [3]. As a result of the search for single-nucleotide polymorphic substitutions with the expected phenotypic effect in the promoter and intron regions, a number of MMP gene polymorphisms, particularly polymorphism in metalloproteinase 9 rs3918242435, were identified using bioinformatics methods [2]. As known, MMP-9 (gelatinase-B) is one of the enzymes engaged in remodeling of extracellular matrix, mobilization of matrix-related growth factors, and cytokine processing [1].…”

Section: Introductionmentioning

confidence: 99%

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Effect of the genetic variability of metalloproteinase 9 rs3918242435 gene polymor-phism on the course and outcome of bronchopulmonary dysplasia in children

Khishtilova¹,

Sergienko²,

Krasovski³

2020

AREM

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The effect of polymorphism in matrix metalloproteinase 9 (MMP-9) rs3918242435 gene on the course and outcome of bronchopulmonary dysplasia (BPD) in children was evaluated. The study proved that despite of association of genotype CC with a short-term respiratory support, it increases the incidence of bronchial obstructive syndrome on the background of the respiratory infections in children, as well as the risk of infection of the respiratory tract with gram-negative microflora and is associated with a long-term therapy with inhaled glucocorticosteroids (ICS).

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Section: O N C L U S I O Nmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the genetic variability of metalloproteinase 9 rs3918242435 gene polymor-phism on the course and outcome of bronchopulmonary dysplasia in children

Khishtilova¹,

Sergienko²,

Krasovski³

2020

AREM

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On the Prospects for Child Disability Prevention Research

Баранов

Terletskaya

2019

Vopr. sovr. pediatr.

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The presented review of the special literature data (on MEDLINE and eLIBRARY.RU databases) makes it possible to determine a number of topical issues for preventing child disability as well as trends of scientific research in this area, taking into account the causes of disability and its structure by the underlying disease. The World Health Organization has established a relentless focus on the problem of disability, including that of children, which is reflected in the continuous improvement of methods for assessing and classifying persistent disabilities. It has been shown that the prevention of disability in children and the support of families raising handicapped children and children with disabilities are among the main priorities of the state social policy of the Russian Federation. The data on modern technologies for reducing the genetic burden in the population from the perspective of prevention of hereditary and congenital diseases, including orphan ones, has been presented. The results of studies indicating the increasing role of the intestinal microbiota in the development and prevention of a number of diseases affecting the formation of disability in children have been presented. The problem of combating antibiotic resistance is considered from a preventive perspective. A number of scientific studies is devoted to non-infectious pathology, which is becoming increasingly important in the formation of disability in children of different age groups, starting from the neonatal period. The actual data on the role of obesity in the formation of serious health disorders has been given. The opinion is expressed on the need to create a system of hygienic and medico-psychological safety of children's life in conditions of hyperinformatisation and the modern environmental situation. It is assumed that the implementation of the results of the proposed research into health care practice will make it possible to influence the processes of disability in a child on a deeper pathogenetic level as well as to improve the arrangement of preventive activities in this direction.

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To the Question of Prevention of Children’s Disability

Yakovleva

Terletskaya

Zelinskaya

2019

jour

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The review of information in special literature (according to databases “MedLine”, and Russian Science Citation Index) given the chance in a new way to present some questions of prevention of children’s disability is presented in article; introduction of results of such research to the practice will allow to influence at deeper pathogenetic level processes of a child disability child and also to improve the organizational moments of scheduled maintenance on this direction. Prevention of children’s disability is considered as the system of measures for health protection of mother and the child throughout the childhood. The priority directions of prevention taking into account the reasons for the formation of disability and its structure on the caused disease are designated. Modern technologies of a decrease in genetic freight in population from a position of prevention of hereditary and congenital pathologies, mental diseases and disorders of behavior are stated. Data on the increasing role of an intestinal microbiota are provided in the development and prevention of a number of the diseases influencing the formation of disability of children. From preventive positions, the problem of the fight against an antibiotiс resistance is considered. A number of scientific research is devoted to noninfectious pathology which gains the increasing value not only from persons of young age but also from teenagers. Relevant data on an obesity role are provided in the formation of violations of health which can become the reason for an invalidation of the child. The position of social hygienists expresses the need of creation of a system of hygienic and medico-psychological health and safety of children for the digital environment which has to become a barrier to the development of deviant behavior at the Internet. The dependence on the Internet can lead to an invalidation. In researches influence of carrying out preventive programs at different stages of development of the child on the decrease in the level of the general disability at children is shown. Creation of a system of early prevention of disability in children and a support of the families which are bringing up disabled children and children with limited opportunities of health are among the main priorities of the state social policy of the Russian Federation.

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Genetic Determination of Bronchopulmonary Dysplasia Formation: Pros and Cons

Cited by 4 publications

References 85 publications

Effect of the genetic variability of metalloproteinase 9 rs3918242435 gene polymor-phism on the course and outcome of bronchopulmonary dysplasia in children

Effect of the genetic variability of metalloproteinase 9 rs3918242435 gene polymor-phism on the course and outcome of bronchopulmonary dysplasia in children

On the Prospects for Child Disability Prevention Research

To the Question of Prevention of Children’s Disability

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