Genetic determinants of host- and virus-derived insertions for hepatitis E virus replication
Michael Hermann Wißing,
Toni Luise Meister,
Maximilian Klaus Nocke
et al.
Abstract:Hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of acute viral hepatitis in humans. Recent data suggest that HEV has a very heterogeneous hypervariable region (HVR), which can tolerate major genomic rearrangements. In this study, we identify insertions of previously undescribed sequence snippets in serum samples of a ribavirin treatment failure patient. These insertions increase viral replication while not affecting sensitivity towards ribavirin in a subgenomic replicon assa… Show more
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