Genetic determinants of circulating levels of tumor necrosis factor receptor II and their association with TNF-RII gene polymorphisms

Vistoropsky, Yulia; Ermakov, Sergey; Toliat, Mohammad Reza; Trofimov, Svetlana; Altmüller, Janine; Malkin, Ida; Nürnberg, Peter; Livshits, Gregory

doi:10.1016/j.cyto.2010.04.013

Cited by 5 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, minor allele carriers of TNFRSF1B, rs976881 had increased risk of loss of response to IFX maintenance therapy. This SNP has been shown to associate with plasma levels of soluble sTNFRII, but has not previously been examined in the context of response to IFX . In support of our finding, CRP increased from initiation to discontinuation of IFX in homozygous carriers of the minor allele of rs976881, but decreased in the other patients.…”

Section: Discussionsupporting

confidence: 83%

Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease

Steenholdt

Enevold

Ainsworth

et al. 2012

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 83%

Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease

Steenholdt

Enevold

Ainsworth

et al. 2012

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Research has shown that rs976881 and rs1061622 are associated with sTNFR2 levels in the periphery, with the rs976881 reference allele (T/T) related to higher sTNFR2 levels than the alternate allele (C/C) (Vistoropsky et al, 2010;Cohen-Woods et al, 2018). In the replication memory clinic cohort in this study, patients with the rs976881 reference allele T/T had lower CSF t-tau and p-tau levels than patients with T/C (given their corresponding CSF sTNFR2 levels).…”

Section: Discussionmentioning

confidence: 59%

“…These two SNPs are located within or in close proximity to the TNFRSF1B gene in the chr1p36 intronic 5' region (rs976881) and a missense coding variant in exon 6 (rs1061622). These SNPs were chosen based on their association with TNFRSF1B-related clinical outcomes and peripheral sTNFR2 levels (Glossop et al, 2005;Vistoropsky et al, 2010;Medrano et al, 2014;Cohen-Woods et al, 2018). Reference, heterozygous, and alternate alleles were T/T, T/C, and C/C, respectively, for rs976881, and G/G, G/T, and T/T, respectively, for rs 1061622.…”

Section: Adni Cohort: Stnfr2 Levelsmentioning

confidence: 99%

TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease

Pillai

Bebek

Khrestian

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Tumor necrosis factor receptor 2 (TNFR2) promotes neuronal survival downstream. This longitudinal study evaluated whether the TNFRSF1B gene encoding TNFR2 and levels of its soluble form (sTNFR2) affect Alzheimer disease (AD) biomarkers and clinical outcomes. Data analyzed included 188 patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who had mild cognitive impairment (MCI) and AD dementia. Further, a replication study was performed in 48 patients with MCI with positive AD biomarkers who were treated at a memory clinic. Cerebrospinal fluid (CSF) sTNFR2 levels along with two related TNFRSF1B gene single nucleotide polymorphisms (SNPs) rs976881 and rs1061622 were assessed. General linear models were used to evaluate the effect of CSF sTNFR2 levels and each SNP in relationship to CSF t-tau and p-tau, cognitive domains, MRI brain measures, and longitudinal cognitive changes after adjustments were made for covariates such as APOE ε4 status. In the ADNI cohort, a significant interaction between rs976881 and CSF sTNFR2 modulates CSF t-tau and p-tau levels; hippocampal and whole brain volumes; and Digit Span Forwards subtest scores. In the replication cohort, a significant interaction between rs976881 and CSF sTNFR2 modulates CSF p-tau. A significant interaction between rs976881 and CSF sTNFR2 also impacts Clinical Dementia Rating Sum of Boxes scores over 12 months in the ADNI cohort. The interaction between TNFRSF1B variant rs976881 and CSF sTNFR2 levels was noted to modulate multiple AD-associated severity markers and cognitive domains. This interaction impacts resilience-related clinical outcomes in AD and lends support to sTNFR2 as a promising candidate for therapeutic targeting to improve clinical outcomes of interest.

show abstract

“…Ronnemma et al attributed two-thirds, 108 and Raggi et al attributed 63% of sTNFR2 variance to additive genetic effects, 76 while others estimated the sTNFR2 heritability to be slightly less (34%, 8 50% 109 ). The most widely reported TNFR2 genetic variant is the +676T>G polymorphism (rs1061622) that replaces the amino acid methionine (M) with arginine (R) at TNFR2 position 196 (M196R).…”

Section: Discussionmentioning

confidence: 99%

Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease

Williams¹

2022

JIR

View full text Add to dashboard Cite

Purpose: Heritability (h 2 , the proportion of the phenotypic variance attributable to additive genetic effects) is traditionally assumed to be constant throughout the distribution of the phenotype. However, the heritabilities of circulating C-reactive protein, interleukin-6, plasminogen activator inhibitor type-1 (PAI-1), and monocyte chemoattractant protein-1 (MCP-1) concentrations depend upon whether the phenotype is high or low relative to their distributions (quantile-dependent expressivity), which may account for apparent gene-environment interactions. Whether the heritabilities of other inflammatory biomarkers linked to cardiovascular disease are quantile-dependent remain to be determined. Patients and Methods: Quantile-specific offspring-parent (β OP ) and full-sib regression slopes (β FS ) were estimated by applying quantile regression to the age-and sex-adjusted phenotypes of families surveyed as part of the Framingham Heart Study. Quantile-specific heritabilities were calculated as: h 2 =2β OP /(1+r spouse ) and h 2 ={(1+8r spouse β FS ) 0.5 -1}/(2r spouse ). Results: Heritability (h 2 ± SE) of lipoprotein-associated phospholipase A2 (Lp-PLA 2 ) mass concentrations increased from 0.11 ± 0.03 at the 10 th percentile, 0.08 ± 0.03 at the 25 th , 0.12 ± 0.03 at the 50 th , 0.20 ± 0.04 at the 75 th , and 0.26 ± 0.06 at the 90 th percentile, or 0.0023 ± 0.0006 per each one-percent increase in the phenotype distribution (P linear trend = 0.0004). Similarly, h 2 increased 0.0029 ± 0.0011 (P linear trend = 0.01) for sP-selectin, 0.0032 ± 0.0009 (P linear trend = 0.0001) for soluble intercellular adhesion molecule 1 (sICAM-1), and 0.0026 ± 0.0006 for tumor necrosis factor receptor 2 (TNFR2) (P linear trend = 5.0 × 10 −6 ) per each one-percent increase in their distributions when estimated from β OP . Osteoprotegerin and soluble ST2 heritability also increased significantly with increasing percentiles of their distributions when estimated from β FS . Lp-PLA 2 activity, CD40 ligand, TNFα, interleukin-18, and myeloperoxidase heritability showed no significant quantiledependence. Conclusion:The heritabilities of circulating Lp-PLA 2 -mass, sP-selectin, sICAM-1, TNFR2, osteoprotegerin and soluble ST2 concentrations are quantile-dependent, which may contribute to purported genetic modulations of: 1) sP-selectin's relationships to venous thrombosis, pulmonary hypertension, type 2 diabetes and atorvastatin treatment; 2) sICAM-I's relationships to brain abscess and atorvastatin treatment; and 3) Lp-PLA 2 's relationships to myocardial infarction and preeclampsia.

show abstract

Genetic determinants of circulating levels of tumor necrosis factor receptor II and their association with TNF-RII gene polymorphisms

Cited by 5 publications

References 29 publications

Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease

Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease

TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease

Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease

Contact Info

Product

Resources

About