Genetic determinants of bone mineral content in premature infants

Abstract

Genetic determinants of bone mineral content in prematurely born children at 3 months and 9-11 years of age were studied. The findings suggest that multiple genes are involved in the regulation of site specific bone mass accumulation during childhood. (Arch Dis Child Fetal Neonatal Ed 2001;85:F214-F216)

Maternal primary hyperparathyroidism: Discordant outcomes in a twin pregnancy

“…Di George syndrome was excluded by negative FISH probe, resolution of hypocalcaemia and absent associated clinical features. Genetic differences in vitamin D receptor (VDR) alleles of the twins may explain variance, 7 if twin 1's VDR preferentially used meagre maternal vitamin D stores. No prenatal measurements of maternal calcium level were available.…”

Influence of Genetic Polymorphisms on Bone Disease of Preterm Infants

“…To date, only one study has considered the genetic predisposition to bone mass content (BMC) in premature infants. It was suggested that multiple genes may be involved in the regulation of bone mass during childhood (11).…”