Abstract:Hundreds of genodermatoses show changes of the nails, most commonly among the ectodermal dysplasias. Among the more common nail disorders are: (i) pachyonychia congenita, a group of disorders caused by mutations in one of five keratin genes expressed in the nail matrix, which also features painful plantar keratoderma; (ii) dyskeratosis congenita, characterized by telomerase shortening leading to nail dystrophy, oral leukoplakia and poikiloderma with a high risk of bone marrow failure; (iii) nail–patella syndro… Show more
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