Genetic damage in urban mice exposed to traffic pollution

Ieradi, Luisa Anna; Cristaldi, M.; Mascanzoni, Daniele; Cardarelli, E.; Grossi, R.; Campanella, Luigí

doi:10.1016/0269-7491(95)00109-3

Cited by 45 publications

(16 citation statements)

References 31 publications

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“…Animals from areas contaminated with lead and zinc have high concentrations of these metals in liver and kidney, which, among other effects, was correlated with increased frequencies of micronuclei and sperm abnormalities (15). Cadmium is a potent genotoxic agent and its effects are dependent on the exposure time, probably due to the animals' inability to eliminate this metal from their tissues (17).…”

Section: Resultsmentioning

confidence: 99%

“…The in vivo micronucleus (MN) has been widely used as a cytogenetic test to detect environmental mutagens and has been utilized on wild rodents since 1978 (6,7,8,19,24). Significant correlations between heavy metal contamination and MN have been detected in wild rodents leaving in polluted areas (14,15,22,26). Previous studies using four different species of wild living rodents, house mouse (Mus musculus domesticus), Algerian mouse (Mus spretus), yellow-necked mouse (Apodemus flavicollis) and bank vole (Clethrionomys glareolus), showed that MN frequencies in peripheral blood and bone marrow erythrocytes from Giemsa stained slides were increased in animals collected in contaminated areas from three European countries, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Micronucleus Test from Free Living Rodents as a Biomarker for Environmental Stressin Situ

Chassovnikarova

Atanassov

Kalaydzhieva

et al. 2010

Biotechnology & Biotechnological Equipment

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Micronucleus Test from Free Living Rodents as a Biomarker for Environmental Stressin Situ

Chassovnikarova

Atanassov

Kalaydzhieva

et al. 2010

Biotechnology & Biotechnological Equipment

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“…The presence of spindle poisons at the contaminated areas seems to be an acceptable explanation. The situation for Am reinforces the possibility that erythrocytes and other cell lines in the bone marrow may have different susceptibilities to the same agent (8)(9)(10). It also emphasizes the need for using several end points in distinct cell lines of the individuals in a population to establish the genotoxic environmental profile of an area.…”

Section: Articles • Environmental Genotoxicity Evaluationmentioning

confidence: 89%

Environmental Genotoxicity Evaluation Using Cytogenetic End Points in Wild Rodents

Bueno

Pereira

Rabello-Gay

2000

Environmental Health Perspectives

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The analysis of cytogenetic end points in organisms exposed to chemicals in their natural environment may help in the early detection of genotoxic damage. This methodology was used to evaluate the impact of environmental compounds occurring in the Itajaí Valley, state of Santa Catarina, Southern Brazil. The lumber, textiles, paper, cigarette, and pesticide industries, besides intense rice cultivation, are the main economic sources of the region. Three areas were chosen for this study: an industrial, an agricultural, and a permanent preservation area. Two species of wild rodents naturally occurring in the three areas, Akodon montensis and Oryzomys nigripes, were analyzed.Cytogenetic preparations were obtained using conventional methods. The end points under study were the polychromatic/normochromatic cell ratio (PCE/NCE); the mitotic index (MI); the frequency of cells with micronuclei in the bone marrow and peripheral blood; and the frequency of cells with chromosome aberrations in the bone marrow.The purpose of the study was to determine the performance of the species and cytogenetic end points as indicators of genotoxic activity in the study areas. The results show a) the role of the end points used as biomarkers in the early detection of genotoxic agents and in the identification of species and populations at higher risk; b) the difference in sensitivity of the species selected as bioindicators in relation to the cytogenetic end points analyzed; c) the need to use several end points when trying to establish a genotoxic profile of an area; and d) the need to use at least two sympatric species to detect the presence of genotoxins in each locality. Materials and MethodsCollecting areas. The area of study is located at the Medium Valley of the Itajaí River, state of Santa Catarina, Brazil. We selected three collecting points: a preservation area, to monitor animals not directly exposed to environmental pollution and for comparison with the other two points; a rice field, to evaluate the genotoxic effects of pesticides used in the rice culture; and an industrial area, to assess the effect of industrial, domestic, and agricultural waste.Animals. Because there were no previous records on the diversity and density of wild rodents in the region, we chose the species for this study after the captures. Three criteria were established: range of distribution, including the three selected locals; population density (enough to ensure a sample of approximately 10 animals of each species at each collecting point during a 1-year period); and sympatry.Based on these criteria and on the results of the captures, two species of wild rodents were chosen: Akodon montensis (2n = 24) and Oryzomys nigripes (2n = 62), both well-known cytogenetically. Individuals were live-trapped at the three collecting areas.Cytogenetic preparations and analysis. Once in the laboratory, the animals were weighed, sexed, and marked. One hour after being injected with a 0.01% colchicine solution (1 mL/100 g/body weight), they were killed by ether inhalatio...

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“…Monitoring of urban environment and the regions of large agglomerations needs an analysis of tissues obtained from animals living in close proximity to humans , Skibniewska et al 2011. The contents of biogenic and heavy metals were investigated by examining the synanthropic species of non-domesticated mammals such as, fox, mole, domestic mouse and bat [Ieradi et al 1996, Komarnicki 2000, Luftl et al 2003]. In the accessible literature, only few publications can be found which are devoted to the problem of bioaccumulation of metals in the tissue of carnivore animals which accompany humans.…”

Section: Streszczeniementioning

confidence: 99%

Domestic cat (Felis catus) as a bioindicator of environmental lead contamination / Kot domowy (Felis catus) jako bioindykator zanieczyszczenia środowiska ołowiem

Skibniewski¹,

Kosla²,

Skibniewska³

2013

Ochrona Środowiska I Zasobów Naturalnych - Environmental Protection and Natural Resources

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Genetic damage in urban mice exposed to traffic pollution

Cited by 45 publications

References 31 publications

Micronucleus Test from Free Living Rodents as a Biomarker for Environmental Stressin Situ

Micronucleus Test from Free Living Rodents as a Biomarker for Environmental Stressin Situ

Environmental Genotoxicity Evaluation Using Cytogenetic End Points in Wild Rodents

Domestic cat (Felis catus) as a bioindicator of environmental lead contamination / Kot domowy (Felis catus) jako bioindykator zanieczyszczenia środowiska ołowiem

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