Genetic Counselling and Genetics of Cleft Lip and Cleft Palate

Habib, Zacharias

doi:10.1097/00006254-197807000-00001

Cited by 21 publications

(8 citation statements)

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“…Among these, we estimated a 33 % rate of isolated cleft lip [25]. Although the rate of CP also varies between regions, races, and ethnicities, it is only to a limited degree [25]. All countries were therefore assigned an isolated CP prevalence of 4 per 10,000 live births [27].…”

Section: Methodsmentioning

confidence: 99%

A Model of the Unmet Need for Cleft Lip and Palate Surgery in Low‐ and Middle‐Income Countries

et al. 2016

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Our model provides marked insight into the global surgical backlog due to cleft lip and palate. While the most populated LMICs have the largest number of unrepaired CL/Ps, low-income countries with relatively less healthcare infrastructure have exceptionally high rates (e.g., Cambodia, Afghanistan, and Nepal). These estimates can be used by local and international cleft care organizations to set program priorities, estimate resource requirements, and inform strategies to support cleft care.

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Section: Methodsmentioning

confidence: 99%

A Model of the Unmet Need for Cleft Lip and Palate Surgery in Low‐ and Middle‐Income Countries

et al. 2016

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“…The prevalence of cleft lip with or without cleft palate (CL/P) is ∼1 in 700 live births worldwide (Ferguson, 1988), and affected individuals require surgical repairs, speech therapy, and dental treatments (Ferguson, 1988). Palate development (which consists of the growth, elevation, and fusion of the palatal shelves) starts at 6-8 weeks of gestation in humans; any failure in these process results in cleft palate (Habib, 1978;Mossey et al, 2009). The etiology of cleft palate is complex and involves environmental and genetic factors and their interactions (Dhulipala et al, 2006;Havasi et al, 2013;Buser and Pohl, 2015;Liu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Excessive All-Trans Retinoic Acid Inhibits Cell Proliferation Through Upregulated MicroRNA-4680-3p in Cultured Human Palate Cells

Yoshioka

Ramakrishnan

Shim

et al. 2021

Front. Cell Dev. Biol.

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Cleft palate is the second most common congenital birth defect, and both environmental and genetic factors are involved in the etiology of the disease. However, it remains largely unknown how environmental factors affect palate development. Our previous studies show that several microRNAs (miRs) suppress the expression of genes involved in cleft palate. Here we show that miR-4680-3p plays a crucial role in cleft palate pathogenesis. We found that all-trans retinoic acid (atRA) specifically induces miR-4680-3p in cultured human embryonic palatal mesenchymal (HEPM) cells. Overexpression of miR-4680-3p inhibited cell proliferation in a dose-dependent manner through the suppression of expression of ERBB2 and JADE1, which are known cleft palate-related genes. Importantly, a miR-4680-3p-specific inhibitor normalized cell proliferation and altered expression of ERBB2 and JADE1 in cells treated with atRA. Taken together, our results suggest that upregulation of miR-4680-3p induced by atRA may cause cleft palate through suppression of ERBB2 and JADE1. Thus, miRs may be potential targets for the prevention and diagnosis of cleft palate.

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“…There may also be differences attributabe to allelic restriction in the ancestors of various populations. 14 Some investigations have shown that the incidence of orofacial clefts is the highest among Asians, followed by whites, and the lowest in people of African descent, 2,15,16 and this discrepancy persists after resettlement or relocation, which lends support to a genetic cause. 2 Another factor contributing to true population rate differences in orofacial clefts is variation in environmental exposures.…”

Section: Discussionmentioning

confidence: 99%

Had Prevalence of Cleft Lip and Palate Differed During the Iran-Iraq War?

Jahanbin

Kianifar²,

Yaghoubi-al³

et al. 2013

Journal of Craniofacial Surgery

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Cleft lip and palate are among the most common congenital defects with multifactorial etiology, and maternal stress may have a role in the development of the malformation; thus, the aim of this study was to explore the role of war on cleft lip and palate (CL/P) prevalence.In this study, records of 101,435 newborn infants delivered in the teaching hospitals of Mashhad and Ahwaz during wartime (1982-1987) and recent years (2005-2010) were reviewed. Samples were analyzed for prevalence of anomaly in both cities at 2 time intervals as well as some related factors; χ and t tests were used for data analysis.Results showed the incidences of CL/P in Mashhad during 1982 to 1987 and 2005 to 2010 were 2 and 2.2 per 1000 live births, respectively; however, its incidence in Ahwaz was 1 per 1000 during wartime and 0.7 per 1000 live births for recent years.Despite significant differences that were found in the prevalence of both cities in recent years (P = 0.001), no significant differences were observed during wartime (P = 0.28).The results revealed that CL/P was more prevalent in both cities, but in contrast to Ahwaz, cleft lip was more prevalent than isolated cleft palate in Mashhad, and significant differences were found between both cities (P = 0.007).The study concluded that the prevalence of CL/P in Ahwaz decreased after the war. However, in Mashhad, its prevalence, which was not affected during wartime, gradually increased. Thus, genetic research may be necessary to establish a genetic predisposition in northeast Iran.

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Genetic Counselling and Genetics of Cleft Lip and Cleft Palate

Cited by 21 publications

References 0 publications

A Model of the Unmet Need for Cleft Lip and Palate Surgery in Low‐ and Middle‐Income Countries

A Model of the Unmet Need for Cleft Lip and Palate Surgery in Low‐ and Middle‐Income Countries

Excessive All-Trans Retinoic Acid Inhibits Cell Proliferation Through Upregulated MicroRNA-4680-3p in Cultured Human Palate Cells

Had Prevalence of Cleft Lip and Palate Differed During the Iran-Iraq War?

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