Genetic control of immunity to Eimeria tenella. Interaction of MHC genes and non-MHC linked genes influences levels of disease susceptibility in chickens

Lillehoj, Hyun S.; Ruff, M. D.; Bacon, Larry D.; Lamont, Susan J.; Jeffers, T. K.

doi:10.1016/0165-2427(89)90094-9

Cited by 74 publications

(29 citation statements)

References 28 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The damage caused by the invasion of the second generation merozoites into the mucosal linings of the cecum affects the functional integrity of the cecum, which may lead to secondary bacterial infection and cellular infiltration (22,26); this may perhaps explain the diffuse cellular infiltration observed histopathologically in the infected groups of birds. According to the World Association for the Advancement of Veterinary Parasitology, the severity of coccidia infection in birds can be measured by the effect of the infection on the weight gain and FCR (8).…”

Section: Discussionmentioning

confidence: 99%

Response of 2 breeds of broiler chicks to experimental infection with low dose of Eimeria tenella sporulated oocysts

Jatau¹,

Odika²,

Thlama³

et al. 2014

Turk J Vet Anim Sci

View full text Add to dashboard Cite

This study evaluated the effect of low-grade Eimeria tenella infections in broiler chicks of Cobb (C) and Marshal (M) breeds. Birds from the experimental group of each breed were orally infected with 3000 sporulated oocysts of E. tenella and examined for weight gain, feed conversion ratio (FCR), packed cell volume (PCV), total leukocyte count (WBC), total plasma protein (TP), gross lesion scores, and histopathological changes 10 days after infection. There were 31.7% and 15.7% reductions in the mean weight gain of experimental groups of C and M, respectively, compared to their controls; this was statistically significant (P < 0.05) in C but not (P > 0.05) in M. Differences in FCR values between infected and control groups were 0.4 and 0.04 in C and M, respectively. There were no significant differences (P > 0.05) between the mean PCV and WBC values of the infected and control groups in either breed, but the mean TP values were significantly lower (P < 0.05) in the experimental groups of both breeds. Mean gross lesion scores were significantly higher in C than in M (P < 0.05) but the histopathological changes observed were similar in both breeds.

show abstract

Section: Discussionmentioning

confidence: 99%

Response of 2 breeds of broiler chicks to experimental infection with low dose of Eimeria tenella sporulated oocysts

Jatau¹,

Odika²,

Thlama³

et al. 2014

Turk J Vet Anim Sci

View full text Add to dashboard Cite

show abstract

“…A comprehensive review on the MHC linkage with differences in disease resistance has been given in several papers: resistance to viral infections [18,42,66,88,104,133,137], resistance to bacterial infections [29,46,122], resistance to protozoal infection [21,86,129], and autoimmune diseases [114].…”

Section: Definition Mhc and Disease Resistancementioning

confidence: 99%

Immunological basis of differences in disease resistance in the chicken

Zekarias

Huurne²,

Landman

et al. 2002

Vet. Res.

View full text Add to dashboard Cite

-Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors. In the adaptive immunity, T cell and B cell responses, the specific recognition of antigens and interactions between antigen presenting cells, T cells and B cells are crucial. It occurs through a network of mediator proteins such as the molecules of the major histocompatibility complex (MHC), T cell receptors, immunoglobulins and secreted proteins such as the cytokines and antibodies. The diversity of these proteins that mainly is due to an intrinsic polymorphism of the genes causes phenotypic variation in disease resistance. The well-known linkage of MHC polymorphism and Marek's disease resistance difference represents a classic model revealing immunological factors in resistance differences and diversity of mediator molecules. The molecular bases in any resistance variation to infectious pathogens are vaguely understood. This paper presents a review of the major immune mediators involved in resistance and susceptibility to infectious diseases and their functional mechanisms in the chicken. The genetic interaction of disease resistance with production traits and the environment is mentioned. et les interactions entre les cellules présentant des antigènes, les cellules T et B, sont cruciales. Cela se produit à travers un réseau de protéines médiatrices telles que les molécules du complexe majeur d'histocompatibilité (CMH), les récepteurs des cellules T, les immunoglobulines et les protéines sé-crétées telles que les cytokines et les anticorps. La diversité de ces protéines, qui est surtout due au polymorphisme intrinsèque des gènes, entraîne une variation phénotypique dans la résistance aux maladies. Le lien bien connu entre le polymorphisme du CMH et les différences dans la résistance à la maladie de Marek représente un modèle classique révélant les facteurs immunologiques dans les différences de résistance et la diversité dans les molécules médiatrices. Les bases moléculaires impliquées dans toute variation de résistance aux pathogènes infectieux sont à peu près comprises. Cet article présente une synthèse sur les principaux médiateurs de l'immunité impliqués dans la résis-tance et la sensibilité aux maladies infectieuses chez le poulet et leurs mécanismes fonctionnels. L'interaction génétique entre la résistance aux maladies et les traits de production et l'environnement est mentionnée.

show abstract

“…The immune response to Marek's disease is particularly well characterized in chickens, and Mhc haplotype influences resistance dramatically (Schat and Xing 2000). Other pathogens for which Mhc genes play an important role in resistance in chickens are Rous sarcoma virus and the coccidial protist Eimeria tenella (Collins et al 1985;Lillehoj et al 1989). Patterns of resistance to Rous sarcoma virus support a heterozygote advantage model (Senseney et al 2000).…”

Section: Mhc-disease Associations In Birdsmentioning

confidence: 99%

AnMhcComponent to Kin Recognition and Mate Choice in Birds: Predictions, Progress, and Prospects

Zelano

Edwards

2002

The American Naturalist

124

View full text Add to dashboard Cite

The major histocompatibility complex (Mhc) has been identified as a locus influencing disease resistance, mate choice, and kin recognition in mammals and fish. However, it is unclear whether the mechanisms by which Mhc genes influence behavior in mammals are applicable to other nonmammalian vertebrates such as birds. We review the biology of Mhc genes with particular reference to their relevance to avian mating and social systems. New genomics approaches recently have been applied to the Mhcs of chickens, quail, and several icons of avian behavioral ecology, including red-winged blackbirds (Agelaius phoeniceus) and house finches (Carpodacus mexicanus). The predominance of concerted evolution at avian Mhc loci makes such methods attractive for providing access to this complicated multigene family. Although some biological processes influenced by Mhc in mammals are physiologically implausible for birds, Mhc could influence cues that form well-known bases for mate choice in birds by influencing the health and vigor of individuals. The tight associations of Mhc variation and disease resistance in chickens raise hope that finding associations of Mhc genes, disease, and mate choice in natural populations of birds will be as fruitful as in mammalian systems.

show abstract

Genetic control of immunity to Eimeria tenella. Interaction of MHC genes and non-MHC linked genes influences levels of disease susceptibility in chickens

Cited by 74 publications

References 28 publications

Response of 2 breeds of broiler chicks to experimental infection with low dose of Eimeria tenella sporulated oocysts

Response of 2 breeds of broiler chicks to experimental infection with low dose of Eimeria tenella sporulated oocysts

Immunological basis of differences in disease resistance in the chicken

AnMhcComponent to Kin Recognition and Mate Choice in Birds: Predictions, Progress, and Prospects

Contact Info

Product

Resources

About