Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults

Turcotte, Michelle; Abadi, Arkan; Peralta‐Romero, Jesús; Suárez, Fernando; Reddon, Hudson; Gómez-Zamudio, Jaime; Burguete-García, Ana I.; Cruz, Miguel; Meyre, David

doi:10.1038/s41366-018-0055-8

Cited by 13 publications

(9 citation statements)

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“…General obesity reflects the overall body mass, i.e., a large lean (muscle) mass. Central obesity has been shown to be an accurate measure of abdominal fat accumulation and a better predictor of morbidity and mortality than general obesity [5]. Visceral obesity is a well-known risk factor for many diseases, such as metabolic disease, hemodynamic disease, type 2 diabetes, and stroke [6,7].…”

Section: Introductionmentioning

confidence: 99%

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

Chen

et al. 2020

BMC Endocr Disord

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Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women. Methods: In total, 5373 women aged ≥40 years were recruited from the Jidong and Kailuan communities. Basic information was collected via clinical examination, laboratory testing and standardized questionnaires. The women were stratified into the following three groups: menstrual period, menopausal transition period and postmenopausal period. General obesity was defined as a body mass index (BMI) of ≥28 kg/m 2. Central obesity was defined as a waist-to-hip ratio (WHR) of > 0.85. Visceral obesity was defined as the presence of nonalcoholic fatty liver disease (NAFLD) and increased pericardial fat volume (PFV). Results: The numbers of women in the menstrual, menopausal transition, and postmenopausal periods were 2807 (52.2%), 675 (12.6%) and 1891 (35.2%), respectively. The adjusted odds ratio (OR) and 95% confidence interval (CI) for central obesity among women in the menopausal transition and postmenopausal periods compared with women in the menstrual period were 0.99 (0.82-1.19) and 1.52 (1.26-1.84), respectively. The OR for NAFLD among postmenopausal women was 1.78 (1.44-2.20). The adjusted β-coefficient (standard error, SE) for PFV among postmenopausal women was 41.25 (7.49). The adjusted OR for general obesity among postmenopausal women was 1.01 (0.77-1.34). Conclusions: This study demonstrated that menopause is an independent risk factor for central and visceral obesity but not general obesity.

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Section: Introductionmentioning

confidence: 99%

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

Chen

et al. 2020

BMC Endocr Disord

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“…Particularly, abdominal fat has been confirmed as a risk predictor of HF, and is known to predict mortality in individuals with coronary artery disease or even in the general population [13,14]. The commonly used measurement of abdominal fat is the waist-to-hip ratio (WHR) [13,15,16]. Of note, prior studies were based on a single WHR measure, failing to account for the potential effect of change in WHR values over time [13,17,18].…”

Section: Introductionmentioning

confidence: 99%

Trajectories of Waist-to-Hip Ratio and Adverse Outcomes in Heart Failure with Mid-Range Ejection Fraction

Gao

Wan

et al. 2020

Obes Facts

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Background: Waist-to-hip ratio (WHR) is a strong predictor of mortality in patients with heart failure (HF). However, common WHR trajectories are not well established in HF with mid-range ejection fraction (HFmrEF) persons, and their relationship to clinical outcomes remains uncertain. Method: We prospectively enrolled 1,396 participants with HFmrEF (left ventricular ejection fraction 40-49%) from April 2013 through April 2017. The waist and hip circumferences of the subjects were measured at regular intervals, and the WHR was calculated as waist circumference divided by hip circumference. Latent mixture modeling was performed to identify WHR trajectories. We then used Cox proportional-hazard models to examine the association between WHR trajectory patterns and incident HF, incident cardiovascular disease (CVD), and all-cause mortality. Results: We identified four distinct WHR trajectory patterns: leanmoderate increase (9.2%), medium-stable/increase (32.7%), heavy-stable/increase (48.0%), and heavy-moderate decrease (10.1%). After multivariable adjustment, the heavy-stable/increase and heavy-moderate decrease patterns were associated with an increased all-cause mortality risk (heavy-stable/increase: adjusted hazard ratio [HR] 3.18, 95% confidence interval [CI] 2.75-4.62; heavy-moderate decrease: adjusted HR 2.32, 95% CI 1.71-3.04), incident CVD risk (heavy-stable/increase: adjusted HR 4.03, 95% CI 2.39-4.91; heavy-moderate decrease:

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“…General obesity re ects the overall body mass, i.e., a large lean (muscle) mass. Central obesity has been shown to be an accurate measure of abdominal fat accumulation and a better predictor of morbidity and mortality than general obesity [5]. Visceral obesity is a well-known risk factor for many diseases, such as metabolic disease, hemodynamic disease, type 2 diabetes, and stroke [6,7].…”

Section: Introductionmentioning

confidence: 99%

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

Chen

Liu

et al. 2020

Preprint

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Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women.Methods: In total, 5373 women aged ≥40 years were recruited from the Jidong and Kailuan communities. Basic information was collected via clinical examination, laboratory testing and standardized questionnaires. The women were stratified into the following three groups: menstrual period, menopausal transition period and postmenopausal period. General obesity was defined as a body mass index (BMI) of ≥28 kg/m2. Central obesity was defined as a waist-to-hip ratio (WHR) of >0.85. Visceral obesity was defined as the presence of nonalcoholic fatty liver disease (NAFLD) and increased pericardial fat volume (PFV). Results: The numbers of women in the menstrual, menopausal transition, and postmenopausal periods were 2807 (52.2%), 675 (12.6%) and 1891 (35.2%), respectively. The adjusted odds ratio (OR) and 95% confidence interval (CI) for central obesity among women in the menopausal transition and postmenopausal periods compared with women in the menstrual period were 1.34 (0.87-2.05) and 0.87 (0.57-1.33), respectively. The OR for NAFLD among postmenopausal women was 1.78 (1.44-2.20). The adjusted β-coefficient (standard error, SE) for PFV among postmenopausal women was 41.25 (7.49). The adjusted OR for general obesity among postmenopausal women was 1.01 (0.77-1.34). Conclusions: This study demonstrated that menopause is an independent risk factor for central and visceral obesity but not general obesity.

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Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults

Abstract: 1Background/Objectives: The prevalence of abdominal obesity in Mexican children has risen 2

Cited by 13 publications

References 50 publications

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

Trajectories of Waist-to-Hip Ratio and Adverse Outcomes in Heart Failure with Mid-Range Ejection Fraction

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China

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