Genetic Component of Type 2 Diabetes in a Mexican Population

Sánchez-Pozos, Katy; Márta, Mészáros

doi:10.1016/j.arcmed.2016.12.007

Cited by 17 publications

(10 citation statements)

References 99 publications

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“…Phenotypic differences between Asian and European T2DM individuals included weight, BMI and fat distribution [50]. The "Asian T2DM phenotype" was characterized by normal weight, BMI and height in conjunction with central obesity and thin limbs [51]. In contrast to the present study, another sample of adult Zapotecs with T2DM had, on average, a BMI that was elevated compared to non-T2DM individuals and an increased frequency of obesity [39].…”

Section: Discussioncontrasting

confidence: 77%

Type 2 Diabetes Phenotype in a Small Isolated Zapotec-Speaking Community in the Valley of Oaxaca, Southern Mexico

Little¹,

Malina²,

Reyes³

et al. 2020

OJEMD

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Objective: To test the hypothesis that the type 2 diabetes mellitus (T2DM) phenotype in an indigenous population is characterized by proportionally short legs and obesity. Methods: Anthropometric characteristics were compared in females and males with T2DM (n = 20, n = 8, respectively) and without T2DM (n = 117, n = 93, respectively). Factor analysis derived dimensions were regressed on T2DM in logistic regression. Results: Weight, sitting height ratio and hip circumference were significantly lower (p < 0.0001) in females, while waist: hip ratio was significantly higher among women and men with T2DM (p < 0.0001 and p < 0.008, respectively). Arm circumference, triceps skinfold, arm muscle circumference, and right and left grip strength were significantly lower among T2DM women (p < 0.0001 for each). Five rotated principal components accounted for 86.7% of the variance: muscular (grip) strength (29.6%), body mass (27.9%), central adiposity (10.7%), body height (9.3%), and trunk length (9.2%). Regression of factors on T2DM status among females indicated muscle strength (OR = 0.16, 95% CI: 0.04-0.71) and central adiposity (OR = 13.76, 95% CI: 3.80-49.83) were predictors of T2DM. In males, muscle strength (OR = 0.28, 95% CI: 0.07-1.08, p < 0.06) and central adiposity significantly predicted T2DM (OR = 3.17, 95% CI: 95% 1.11-9.04, p < 0.008). Conclusion: Reduced muscle strength/mass and increased central adiposity characterize the T2DM phenotype.

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Section: Discussioncontrasting

confidence: 77%

Type 2 Diabetes Phenotype in a Small Isolated Zapotec-Speaking Community in the Valley of Oaxaca, Southern Mexico

Little¹,

Malina²,

Reyes³

et al. 2020

OJEMD

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“…For example, it has been demonstrated that Mexicans have a genetic variant known as SLC16A (and other genetic variants) that increase the probability of developing T2D by 25% and explains 20% of the current prevalence. [23][24][25] Additionally, it has been shown that the intrauterine environment conditions the occurrence of T2D and that a lower birth weight or a weight higher than the adequate weight at a young age contributes to the development of different metabolic pathologies at later ages. 12 Another factor associated with the increase in T2D at younger ages is an increase in obesity and overweight in younger individuals.…”

Section: Discussionmentioning

confidence: 99%

<p>Sex disparities in the epidemic of type 2 diabetes in Mexico: national and state level results based on the Global Burden of Disease Study, 1990–2017</p>

Dávila-Cervantes

Agudelo-Botero

2019

DMSO

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Purpose: To analyze the type 2 diabetes (T2D) health burden in Mexico by sex at the national and state levels from 1990 to 2017. Methods: This was a secondary analysis based on data from the Global Burden of Disease Study, 1990-2017. We used the indicators of mortality rates, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs). Results: At the national level, there was an increase in the standardized mortality rates, YLLs, YLDs and DALYs, especially in the male group. At the state level, the health impacts of T2D varied within the population and did not exhibit any clearly defined geographic pattern. However, the most pronounced increases in the various indicators occurred in the poorer states of the country. Conclusion: T2D continues to have a dominant impact on Mexican public health, with marked disparities between the states. Working to reduce these health inequalities is necessary, and resources must be focused on the priority groups, for example, men, young and middle-aged adults, and individuals living in the states with the highest index of marginalization.

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“…Cardiovascular disease (CD) is the main cause of death among Mexican adults, and cardiovascular events are induced by obesity and/or T2D [6]. More than 20 single nucleotide polymorphisms (SNPs) have been associated with T2D [7], but polymorphisms related to cardiovascular risk have been poorly investigated in Mexican patients with T2D. Thus, we chose five SNPs associated with obesity and CD, to assess their association with T2D, namely, CXCL12 (stromal cell-derived factor 1 precursor) rs501120, CDKN2A/B (kinase inhibitor 2A) rs1333049, HNF-1 α (hepatocyte nuclear factor-1alpha) rs2259816, FTO (fat mass and obesity) rs9939609, and LEP (leptin) rs7799039.…”

Section: Introductionmentioning

confidence: 99%

Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos

et al. 2019

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Background and objectives: Type 2 diabetes (T2D) is a major problem of public health in Mexico. We investigated the influence of five polymorphisms, previously associated with obesity and cardiovascular disease in Europeans and Asians, on T2D in Mexican Mestizos. Materials and Methods: A total of 1358 subjects from 30 to 85 years old were genotyped for five loci: CXCL12 rs501120; CDNK2A/B rs1333049; HNF-1α rs2259816; FTO rs9939609; and LEP rs7799039. We used logistic regressions to test the effect of each locus on T2D in two case–control groups with obesity and without obesity. Also, linear regression models on glucose and glycated hemoglobin (HbA1c) were carried out on the whole sample, adjusted by age, gender, and body mass index. Results: The CXCL12 rs501120 C allele (OR = 1.96, p = 0.02), the FTO rs9939609 A allele (OR = 2.20, p = 0.04) and the LEP rs7799039 A allele (OR = 0.6, p = 0.03) were significantly associated with T2D in obesity case–control group. No significant association was found in the non-obesity case–control group. The linear regression model showed that CDNK2A/B rs1333049 C allele (β = 0.4, p = 0.03) and FTO rs9939609 A allele (β = 0.5, p = 0.03), were significantly associated with HbA1c, but no association was found among the loci with the glucose levels. Conclusions: Polymorphisms previously linked with obesity and cardiovascular events were also associated with T2D and high levels of HbA1c. Furthermore, we must point at the fact that this is the first report where polymorphisms CXCL12 rs501120 and LEP rs7799039 are associated with T2D in subjects with obesity.

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Genetic Component of Type 2 Diabetes in a Mexican Population

Cited by 17 publications

References 99 publications

Type 2 Diabetes Phenotype in a Small Isolated Zapotec-Speaking Community in the Valley of Oaxaca, Southern Mexico

Type 2 Diabetes Phenotype in a Small Isolated Zapotec-Speaking Community in the Valley of Oaxaca, Southern Mexico

<p>Sex disparities in the epidemic of type 2 diabetes in Mexico: national and state level results based on the Global Burden of Disease Study, 1990–2017</p>

Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos

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