Genetic characterization of two low pathogenic avian influenza virus H5N1 isolates from Ontario, Canada

Pei, Yanlong; Swinton, Janet; Ojkić, Davor; Sharif, Shayan

doi:10.1007/s11262-008-0311-4

Cited by 5 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our speculation coincides with other studies which demonstrated that highly pathogenic H5N1 virus infection in mice model could cause a down-regulation of TGF-β secretion which resulted in more severe and widespread lesions [51]. These may also account for the difference in pathogenicity of different AIV strains [52,53]. …”

Section: Discussionsupporting

confidence: 92%

Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses

Lam

Yeung

Chu

et al. 2010

Virol J

View full text Add to dashboard Cite

Influenza pandemic remains a serious threat to human health. In this study, the repertoire of host cellular cytokine and chemokine responses to infections with highly pathogenic avian influenza H5N1, low pathogenicity avian influenza H9N2 and seasonal human influenza H1N1 were compared using an in vitro system based on human pulmonary epithelial cells. The results showed that H5N1 was more potent than H9N2 and H1N1 in inducing CXCL-10/IP-10, TNF-alpha and CCL-5/RANTES. The cytokine/chemokine profiles for H9N2, in general, resembled those of H1N1. Of interest, only H1N1, but none of the avian subtypes examined could induce a persistent elevation of the immune-regulatory cytokine - TGF-β2. The differential expression of cytokines/chemokines following infection with different influenza viruses could be a key determinant for clinical outcome. The potential of using these cytokines/chemokines as prognostic markers or targets of therapy is worth exploring.

show abstract

Section: Discussionsupporting

confidence: 92%

Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses

Lam

Yeung

Chu

et al. 2010

Virol J

View full text Add to dashboard Cite

show abstract

“…Both Australian and American continents were omitted from the map because of no report of highly pathogenic avian influenza H5N1 outbreaks to date (Pei et al, 2009;Yee et al, 2009). Figure 2a shows the locations of the outbreaks.…”

Section: Datamentioning

confidence: 99%

Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns

et al. 2009

View full text Add to dashboard Cite

Abstract. The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant pandemic threat and a serious public health risk. An efficient surveillance and disease control system relies on the understanding of the dispersion patterns and spreading mechanisms of the virus. A space-time cluster analysis of H5N1 outbreaks was used to identify spatio-temporal patterns at a global scale and over an extended period of time. Potential mechanisms explaining the spread of the H5N1 virus, and the role of wild birds, were analyzed. Between December 2003 and December 2006, three global epidemic phases of H5N1 influenza were identified. These H5N1 outbreaks showed a clear seasonal pattern, with a high density of outbreaks in winter and early spring (i.e., October to March). In phase I and II only the East Asia Australian flyway was affected. During phase III, the H5N1 viruses started to appear in four other flyways: the Central Asian flyway, the Black Sea Mediterranean flyway, the East Atlantic flyway and the East Africa West Asian flyway. Six disease cluster patterns along these flyways were found to be associated with the seasonal migration of wild birds. The spread of the H5N1 virus, as demonstrated by the space-time clusters, was associated with the patterns of migration of wild birds. Wild birds may therefore play an important role in the spread of H5N1 over long distances. Disease clusters were also detected at sites where wild birds are known to overwinter and at times when migratory birds were present. This leads to the suggestion that wild birds may also be involved in spreading the H5N1 virus over short distances.

show abstract

“…Viruses of the N1, N2, and N3, and less frequently N6 and N7, neuraminidase types that harbor a 20-to 30-amino-acid deletion in the NA stalk have been isolated from domestic poultry (2,4,7,10,13,14,19). Such a deletion was also observed upon experimental transmission to quail or chickens of viruses belonging to the H2N2 (24,25), H7N3 (8), H9N2 (9), and H11N9 (11,12) subtypes.…”

mentioning

confidence: 99%

Length Variations in the NA Stalk of an H7N1 Influenza Virus Have Opposite Effects on Viral Excretion in Chickens and Ducks

Hoffmann

Munier

Larcher

et al. 2012

J Virol

View full text Add to dashboard Cite

A deletion of ϳ20 amino acids in the stalk of neuraminidase is frequently observed upon transmission of influenza A viruses from waterfowl to domestic poultry. A pair of recombinant H7N1 viruses bearing either a short-or long-stalk neuraminidase was genetically engineered. Inoculation of the long-stalk-neuraminidase virus resulted in a higher cloacal excretion in ducks and led conversely to lower-level oropharyngeal excretion in chickens, associated with a higher-level local immune response and better survival. Therefore, a short-stalk neuraminidase is a determinant of viral adaptation and virulence in chickens but is detrimental to virus replication and shedding in ducks.

show abstract

Genetic characterization of two low pathogenic avian influenza virus H5N1 isolates from Ontario, Canada

Cited by 5 publications

References 25 publications

Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses

Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses

Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns

Length Variations in the NA Stalk of an H7N1 Influenza Virus Have Opposite Effects on Viral Excretion in Chickens and Ducks

Contact Info

Product

Resources

About