Genetic characterization of Staphylococcus aureus isolates causing bloodstream infections in Austria

Luxner, Josefa; Zarfel, Gernot; Johler, Sophia; Feierl, Gebhard; Leitner, Eva; Hoenigl, Martin; Grisold, Andrea

doi:10.1016/j.diagmicrobio.2013.10.010

Cited by 8 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seventy-four publications were identified. Human infections of any type have been reported in Austria [21][22][23][24], Belgium [23,25,26], Denmark [23,[27][28][29][30][31], Finland [23,32], France [33-35, 36•, 37-39], Germany [23,[40][41][42][43][44], Greece [45], Italy [46][47][48][49][50][51], the Netherlands [23,[52][53][54][55][56][57][58][59][60][61][62][63], Norway [64], Spain [65][66][67][68][69][70][71], Sweden…”

Section: Geographic Distribution Of Casesmentioning

confidence: 99%

“…A spectrum of CC398 infections has been documented, ranging from relatively minor or localized infections (including abscesses [46,62,64,72,87,99,100] and various SSTIs [11,18,21,30,31,37,48,53,60,66,69,74,77,79,80,85,101]; urinary tract infections [60,62]; wound infections [21, 26, 32, 40, 59-62, 72, 75, 86, 100, 102]; mastitis [15]; otitis [51,60]; tonsillitis [31], and conjunctivitis [22]) to more serious or invasive infections (including bacteremia [12,24,26,28,33,34,37,43,45,48,60,62,63,81,84,86]; pneumonia, including necrotizing pneumonia…”

Section: Types Of Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Human Infections with Staphylococcus aureus CC398

Smith

Wardyn

2015

Curr Envir Health Rpt

View full text Add to dashboard Cite

Staphylococcus aureus isolates belonging to clonal cluster 398 (CC398) have emerged over the previous decade as a risk to livestock workers. Though most of the research to date has focused on colonization with these strains, a number of infections have also been documented, ranging from mild skin infections to more serious invasive infections and even death. Here, we review existing reports of human infections with CC398 and discuss their geographic distribution, general characteristics, and implications for future research. We identified 74 publications describing CC398 infections in humans in 19 different countries, suggesting this is an emerging worldwide issue.

show abstract

Section: Geographic Distribution Of Casesmentioning

confidence: 99%

Section: Types Of Infectionsmentioning

confidence: 99%

Human Infections with Staphylococcus aureus CC398

Smith

Wardyn

2015

Curr Envir Health Rpt

View full text Add to dashboard Cite

show abstract

“…Studies carried out in Austria reported that up to 8% of all isolated MRSA are LA-MRSA and 10%–20% can be assigned to CA-MRSA. The majority of LA-MRSA detected in humans are considered to be a colonization only (healthy carriers) but also serious infections have been reported [ 5 , 11 , 12 , 13 , 14 ]. The mec A gene, which is responsible for methicillin resistance, is located on SCC mec cassettes.…”

Section: Introductionmentioning

confidence: 99%

Multiresistant Bacteria Isolated from Chicken Meat in Austria

Zarfel

Galler

Luxner

et al. 2014

IJERPH

Self Cite

View full text Add to dashboard Cite

Multidrug resistant bacteria (MDR bacteria), such as extended spectrum beta-lactamase (ESBL) Enterobacteriaceae, methicillin resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE), pose a challenge to the human health care system. In recent years, these MDR bacteria have been detected increasingly outside the hospital environment. Also the contamination of food with MDR bacteria, particularly of meat and meat products, is a concern. The aim of the study was to evaluate the occurrence of MDR bacteria in chicken meat on the Austrian market. For this study, 50 chicken meat samples were analysed. All samples originated from chickens slaughtered in Austrian slaughterhouses and were marked as produced in Austria. Samples were analysed for the presence of ESBL Enterobacteriaceae, methicillin resistant Staphylococci and VRE. Resistance genes of the isolated bacteria were characterised by PCR and sequencing. In the present study 26 ESBL producing E. coli, five mecA gene harbouring Staphylococci (but no MRSA), and four VRE were detected in chicken meat samples of Austrian origin. In 24 (48%) of the samples no ESBL Enterobacteriaceae, MRSA, methicillin resistant coagulase negative Staphylococcus (MRCNS) or VRE could be detected. None of the samples contained all three types of investigated multiresistant bacteria. In concordance to previous studies, CTX-M-1 and SHV-12 were the dominant ESBL genes.

show abstract

“…aureus colonization and infection [72][73][74]. S. aureus colonization and infection has been associated with swine, cattle, and poultry.…”

Section: 6mentioning

confidence: 99%

“…Infections ranging from SSTIs [72,102] to wound infections [107,108], otitis [92], bacteremia [74,98,109], and pneumonia [72,110] or gentamicin is not recommended. Rifampin and vancomycin combination therapy is recommended for infective endocarditis of a prosthetic valve [112].…”

Section: La-mrsa Associated Strainsmentioning

confidence: 99%

The human nasal and oropharyngeal microbiomes and Staphylococcus aureus colonization

Kates¹

View full text Add to dashboard Cite

Staphylococcus aureus has been extensively studied, yet it remains unclear why certain individuals continually carry the bacteria while others do not. Livestock workers are known to be at an increased risk of S. aureus colonization, but have not been as studied as other high risk groups, including hospitalized patients, have been. Culture based studies have shown other bacteria may decrease the likelihood of S. aureus colonization. Here, we utilize 16s rRNA sequencing to better characterize the ecologic relationships between S. aureus and the other microbes in the nares and oropharynx in a population of livestock workers.A cross-sectional, epidemiological study was conducted enrolling 59 participants (26 of which had livestock contact) in Iowa. Participants were enrolled in one of four ways: from an existing prospective cohort study (n=38), from the Iowa Department of Natural Resources Animal Feeding Operations database (n=17), through Iowa county fairs (n=3), and through snowball sampling (n=1). We collected two sets of swabs from the nares and oropharynx of each participant. The first set of swabs was used to assess the microbiome via 16s rRNA sequencing and the second was used to culture S. aureus.We observed livestock workers to have greater diversity in their microbiomes compared to those with no livestock contact. In the nares, there were 26 operational taxonomic units found to be different between livestock workers and non-livestock workers with the greatest difference seen with Streptococcus and Proteobacteria. In the oropharynx, livestock workers with swine exposure were more likely to carry several pathogenic organisms. We also observed colonized livestock workers to be more likely to

show abstract

Genetic characterization of Staphylococcus aureus isolates causing bloodstream infections in Austria

Cited by 8 publications

References 18 publications

Human Infections with Staphylococcus aureus CC398

Human Infections with Staphylococcus aureus CC398

Multiresistant Bacteria Isolated from Chicken Meat in Austria

The human nasal and oropharyngeal microbiomes and Staphylococcus aureus colonization

Contact Info

Product

Resources

About