2008
DOI: 10.1007/s00705-008-0097-7
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Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand

Abstract: Swine have been known to be a suitable host for influenza A virus. In Thailand, phylogenetic analysis on swine influenza virus (SIV) has as yet not been attempted. The present report presents molecular and phylogenetic analysis performed on SIV in Thailand. In this study, 12 SIV isolates from the central and eastern part of Thailand were subtyped and the molecular genetics of hemagglutinin and neuraminidase were elucidated. Three subtypes, H1N1, H1N2 and H3N2, are described. Phylogenetic analysis of the SIV he… Show more

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Cited by 38 publications
(33 citation statements)
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“…The HA1 subunit includes the globular head and contains fi ve major antibody binding sites, namely Sa, Sb, Ca1, Ca2 and Cb. [17][18][19] A substitution at residue 171 (K171E) occurred in the Ca antigenic site in A/Delhi/NIV3610/2009 isolate, the substitution at residue 208 (L208I) which is located in the Ca site present in the A/Che/NIV658/2009 strain. A substitution at residue 240 (Q240R) also occurred in the Ca antigenic site of two different strains like A/Blore/NIV236/2009 and A/Jalna /NIV9436/2009 isolates.…”
Section: Discussionmentioning
confidence: 99%
“…The HA1 subunit includes the globular head and contains fi ve major antibody binding sites, namely Sa, Sb, Ca1, Ca2 and Cb. [17][18][19] A substitution at residue 171 (K171E) occurred in the Ca antigenic site in A/Delhi/NIV3610/2009 isolate, the substitution at residue 208 (L208I) which is located in the Ca site present in the A/Che/NIV658/2009 strain. A substitution at residue 240 (Q240R) also occurred in the Ca antigenic site of two different strains like A/Blore/NIV236/2009 and A/Jalna /NIV9436/2009 isolates.…”
Section: Discussionmentioning
confidence: 99%
“…In Asia, the situation is even more complex as, in addition to the above viruses, Eurasian avian-like H1N1 SIVs are present (1,6,7,10).…”
Section: Discussionmentioning
confidence: 99%
“…the surface glycoproteinshaemagglutinin (HA) and neuraminidase (NA). Three SIV subtypes: H1N1, H3N2, and H1N2 are currently circulating throughout pig populations worldwide (1,4,6,10,22,31,32).…”
mentioning
confidence: 99%
“…Swine can be infected with multiple influenza subtypes and may serve as ''mixing vessels'' for mixed infections and potential genetic reassortment among avian, human, and porcine influenza viruses (Kida et al, 1994;Ito et al, 1998). Currently, H1N1, H1N2, and H3N2 influenza viruses are the main subtypes cocirculating in swine populations worldwide (Yu et al, 2007;Chutinimitkul et al, 2008;Van Reeth et al, 2008). H5 and H9 avian influenza infections were also detected in swine in China (Ninomiya et al, 2002).…”
Section: Introductionmentioning
confidence: 99%