Genetic characterization of fowl adenovirus serotype 4 isolates in Southern China reveals potential cross-species transmission

Shen, Zhujie; Xiang, Bin; Li, Shibin; Ren, Xiaopeng; Hong, Yanfen; Liao, Jiayu; Yu, De‐Quan; Ren, Tao; Liao, Ming; Xu, Chunyan

doi:10.1016/j.meegid.2019.103928

Cited by 18 publications

(15 citation statements)

References 37 publications

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“…The typical necropsy lesion is characterized by accumulation of clear, straw-colored fluid in the pericardial sac, as well as multifocal areas of necrosis in liver and hepatitis [8]. Additionally, HHS has been reported in pigeons [10], quails [11], ducks [12], and mandarin ducks [13]. The prevalence of HHS in China was relatively low with only sporadic outbreaks before 2015.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors

Wang

Zhao

2019

Viruses

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Since 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS), caused by hypervirulent fowl adenovirus serotype 4 (FAdV-4), have emerged in several provinces in China, posing a great threat to poultry industry. So far, factors contributing to the pathogenesis of hypervirulent FAdV-4 have not been fully uncovered. Elucidation of the pathogenesis of FAdV-4 will facilitate the development of effective FAdV-4 vaccine candidates for the control of HHS and vaccine vector. The interaction between pathogen and host defense system determines the pathogenicity of the pathogen. Therefore, the present review highlights the knowledge of both viral and host factors contributing to the pathogenesis of hypervirulent FAdV-4 strains to facilitate the related further studies.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors

Wang

Zhao

2019

Viruses

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“…These strains shared nearly 100% genomic sequence identity with the CH-GD-12-2014 strain in the hexon, fiber-1 , and fiber-2 proteins. Contrastingly, all four isolates shared only 86.9% amino acid sequence identity in the Hexon with DAdV-2 GR ( Yin et al, 2018 ; Shen et al, 2019 ). These data suggested that CH-GD-12-2014, along with the FJGT01, AHAQ13, ZJJH07, and GDMM10 strains, should be classified under DAdV-3.…”

Section: Introductionmentioning

confidence: 81%

“…As per the classification by the International Committee on Taxonomy of Viruses ( ICTV ), DAdVs comprise DAdV-1 (duck adenovirus A) in the genus Atadenovirus and DAdV-2 (duck aviadenovirus B) in the genus Aviadenovirus. DAdV-1 infections are usually asymptomatic in waterfowls as natural hosts ( Hollmén et al, 2003 ; Brash et al, 2009 ; Shen et al, 2019 ). In 2014, the complete genome of DAdV-2 strain GR was sequenced by Ana Marek and was proposed as a new member of the genus Aviadenovirus, which was first isolated from Muscovy ducks in France in 1982 ( Marek et al, 2014 ; Huang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Isolation and pathogenic characterization of duck adenovirus 3 mutant circulating in China

et al. 2022

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Duck adenoviruses ( DAdVs ) include serotype 1 ( DAdV-1 ) in the genus Atadenovirus and serotypes 2-4 (DAdV-2, 3, and 4) in the genus Aviadenovirus. DAdV-3 was initially isolated from Chinese Muscovy ducks in 2014, whereby the infected ducks exhibited yellowing and hemorrhaging in the liver, along with slight pericardial effusion, swelling, and hemorrhaging in the kidneys. In recent years, duck adenovirus infections have appeared in Muscovy duck farms in Fujian, Zhejiang, Anhui, Guangdong, and other places in China. They have an incidence rate of 40 to 55% and a mortality rate of 35 to 43%, resulting in great losses to the duck breeding industry. In this study, 7 DAdV-3 strains, designated as TZ193, FJPT20161124, GX20170519, FJZZ, GDMM, AHAQ, and GDHS were isolated from Muscovy ducks in different provinces of China during 2016–2019, and their complete genomics were sequenced. Their genomes all exhibited significant deletions in ORF67 , which also had G to A transitions at the 41st and 977th nt positions, resulting in a stop codon. The pathogenicity of TZ193, a novel isolate of DAdV-3, was investigated in Muscovy ducks. TZ193 caused characteristic lesions of swelling as well as hemorrhagic liver and kidney in the infected ducklings. Moreover, the mortality rate of TZ193 in 5-day-old domestic ducks was 100%. Our data provide concrete evidence for the identification of the DAdV-3 novel variant mutant in China, which effects increased mortality in ducks. This highlights the necessity for monitoring the specific molecular epidemiology of novel DAdV-3 mutants and the development of new vaccines in the future.

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“…In addition to 3-5-week-old broilers, other avian species, including hens, ducks, pigeons, and quails, could also be infected by FAdV on some occasions [22]. The mortality of this disease could reach up to 80% of susceptible chickens in China [23]. Thus, HHS remains a severe threat to the stakeholders.…”

Section: Discussionmentioning

confidence: 99%

A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell

Zhao

Duan

Wang

et al. 2020

Viruses

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Hydropericardium-Hepatitis Syndrome (HHS) caused by Fowl Adenovirus Serotype 4 (FAdV4) infection is a severe threat to the poultry industry worldwide, especially in China since 2015. Recent studies show that FAdV4 induces liver injury through apoptosis. However, the underlying molecular mechanism is still unclear. We report here that FAdV4 infection caused apoptosis in Leghorn male hepatocellular (LMH) cells and that PX, a structural protein of FAdV4, acted as a major viral factor inducing apoptosis. Furthermore, the nuclear localization of PX is determined by the R/K regions of PX and required for PX-induced apoptosis. Moreover, alanines 11 and 129 of PX are crucial to PX-induced apoptosis. Inhibition of FAdV4-induced apoptosis by caspase inhibitors retarded viral replication, suggesting that PX serves as a virulence factor for FAdV4 infection, which may further our understandings of the pathogenesis of FAdV4 infection.

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Genetic characterization of fowl adenovirus serotype 4 isolates in Southern China reveals potential cross-species transmission

Cited by 18 publications

References 37 publications

Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors

Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors

Isolation and pathogenic characterization of duck adenovirus 3 mutant circulating in China

A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell

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