Genetic characterization of four Colombian populations using Investigator® Argus X-12 kit

Builes, J.J.; Mendoza, L.; Gaviria, A.; Zambrano, Ana Karina; Suarez, Néstor; Gutiérrez, Jaiber; Ibarra, A.; Granda, J.D.; Castillo, A.; Gil, A.; Pico, Adriana Lucía; Aguirre, D.

doi:10.1016/j.fsigss.2017.09.090

Cited by 1 publication

(1 citation statement)

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“…The X chromosomal markers (X-STR) are of interest due to their inheritance because it differs from autosomal STR [3]. This characteristic makes them useful in complex cases of kinship, genealogies, massive disasters and other forensic analysis in which at least one woman is involved [4,5]. In addition, due to their high polymorphism information content, they are very informative for population studies of diverse ethnic groups [3].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of 12 X-STRs in the Ecuadorian population

Gaviria¹,

Boada²,

Rodríguez-Pólit³

et al. 2019

Forensic Science International: Genetics Supplement Series

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The X-STR markers represent a powerful tool to complement the information provided by the autosomal and Y chromosome markers, particularly, in cases involving at least one woman. In the present study, allele frequencies, power of exclusion (PE), power of discrimination (PD) and polymorphism information content (PIC) were analyzed for 12 X chromosome loci. A total of 200 unrelated Ecuadorian individuals were selected for the population analysis. The data showed that DXS10135 locus had the highest power of discrimination value (PD = 0.9351), and polymorphism information content (PIC = 0.9313). The heterozygosity observed ranged from 0.9300 to 0.6400. The power of exclusion varied between 0.3417 to 0.8570 for DXS10135 and DXS8378 respectively. No significant departure from Hardy Weinberg equilibrium (HWE) was detected for any of the analyzed markers. The X-STR markers have demonstrated their potential to efficiently complement the analysis to solve complex kinship and forensic cases.

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Section: Introductionmentioning

confidence: 99%