2021
DOI: 10.1371/journal.pone.0255219
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Genetic characterization of extended-spectrum β-Lactamase- and carbapenemase-producing Escherichia coli isolated from Egyptian hospitals and environments

Abstract: Over the past decades, Escherichia coli (E. coli) have acquired extensive resistance to antibiotics; especially β- lactams. This study aimed to investigate the frequency of Extended-spectrum β-lactamase (ESBL) and carbapenemase producers among E. coli isolates and their correlation with serotypes, phylogenetic background, and pathogenicity associated islands. A total of 105 E. coli strains were isolated and subjected to antimicrobial susceptibility testing against β-lactam antibiotics. All isolates showed a hi… Show more

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Cited by 12 publications
(11 citation statements)
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References 38 publications
(52 reference statements)
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“…In accordance with our results, Ortega et al were reported the majority (26.5%) of carbapenemase-producing clinical isolates belonged to phylogroup B2 [ 17 ]. Nonetheless, unlike our findings, El-Shaer et al found that carbapenemase positive clinical isolates were mainly classified as phylogroup C (50%) [ 44 ]. This study showed that E .…”
Section: Discussioncontrasting
confidence: 99%
“…In accordance with our results, Ortega et al were reported the majority (26.5%) of carbapenemase-producing clinical isolates belonged to phylogroup B2 [ 17 ]. Nonetheless, unlike our findings, El-Shaer et al found that carbapenemase positive clinical isolates were mainly classified as phylogroup C (50%) [ 44 ]. This study showed that E .…”
Section: Discussioncontrasting
confidence: 99%
“…These findings were in agreement with previous reports on humans in Iran [ 53 ], China [ 55 ], Sweden [ 36 ], and Spain [ 56 ]. A similar distribution of PAIs with a predominance of PAI IV 536 was reported in many studies [ 12 , 55 , 56 , 57 , 58 , 59 ].…”
Section: Discussionsupporting
confidence: 85%
“…Furthermore, nine of these 11 isolates belonged to B2 phylogroup and two were from B1 group. Most other studies [20][21][22]74] showed the predominance of OXA-48 among E. coli isolates, especially B2 isolates. Other studies in Iraq [75] and around the world [44,[76][77][78][79][80][81][82] also revealed the occurrence of different carbapenemase genes among E. coli isolates.…”
Section: Plos Onementioning
confidence: 88%
“…As it is difficult to develop novel antimicrobial agents, efforts should be concentrated on the prevention of the spread of carbapenemase producers by early detection and reinforced hygiene measures [18] and careful monitoring of use of antimicrobials for UTI treatment is necessary [19]. In addition, predominance of carbapenemases among B2 E. coli isolates was reported from different parts of the world [20][21][22][23]. Hence, this research was designed to evaluate the prevalence of carbapenemase genes and MDR among B2 UPEC isolates from Iraqi outpatients in Wasit Province with acute UTI by multiplex PCR protocols.…”
Section: Introductionmentioning
confidence: 99%