Genetic characterization of chikungunya viruses isolated during the 2015-2017 outbreaks in different states of India, based on their E1 and E2 genes

Patil, J.A.; More, Ashwini; Patil, Poonam; Jadhav, Santosh; Newase, Priyanka; Agarwal, Megha; Amdekar, Sarika; Raut, Chandrashekhar G.; Parashar, Deepti; Cherian, Sarah

doi:10.1007/s00705-018-3974-8

Cited by 19 publications

(19 citation statements)

References 27 publications

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“…A short distance away in Salvador, Brazil, two vertically infected infants developed a rash, fever, and signs of bacterial infection but recovered within a month after delivery, even though one of the infants had developed a grade 1 intracerebral hemorrhage [83]. In 2016, a new E1: K211E mutation was identified in India, Bangladesh, and Brazil through phylogenetic studies (Table 1) [55,95]. It was shown that the E1: K211E mutation correlated with enhanced viral transmission in Ae.…”

Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

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Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Barr

Vaidhyanathan

2019

Viruses

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Chikungunya virus (CHIKV) was first extensively described in children during outbreaks in India and South Asia during the mid-1960s. Prior to the 2005 emergence of CHIKV on Reunion Island, CHIKV infection was usually described as a dengue-like illness with arthralgia in Africa and febrile hemorrhagic disease in Asia. Soon after the 2005 emergence, severe CNS consequences from vertical and perinatal transmission were described and as CHIKV continued to emerge in new areas over the next 10 years, severe manifestation of infection and sequelae were increasingly reported in infants and neonates. The following review describes the global reemergence and the syndromes of Chikungunya fever (CHIKF) in infants and children. The various manifestations of CHIKF are described and connected to the viral lineage that was documented in the area at the time the disease was described. The data show that certain manifestations of CHIKF occur with specific viral lineages and genetic motifs, which suggests that severe manifestations of CHIKF in the very young may be associated with the emergence of new viral lineages.

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Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

“…It was shown that the E1: K211E mutation correlated with enhanced viral transmission in Ae. aegypti though studies linking this mutation with human disease have not been published [55]. Furthermore, published alignments show that many other mutations are present in these outbreak isolates.…”

Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Barr

Vaidhyanathan

2019

Viruses

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“…During the 2006 outbreak, 27 districts including Gulbarga, Tumkur, Bidar, Bellary, Chitradurga, Davangere, Kolar, and Bijapur reported a large number of cases in Karnataka accounting for 762 026 suspected cases reported in India . Even though there had been a marked fall in CHIKV cases in the state in 2007 and 2010, Karnataka and Maharashtra together accounted for nearly 63.1% of the 62 268 cases in the year 2017 . In this context, we decided to estimate the seroprevalence of CHIKV in South Karnataka.…”

Section: Introductionmentioning

confidence: 99%

Estimating the seroprevalence of chikungunya virus exposure in Shimoga district, Karnataka state: A hospital‐based study during 2014‐2018

Shilpa

Kavitha

Sudheesh

et al. 2019

Journal of Medical Virology

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Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes. The disease is characterized by fever, headache, rash, severe joint, and muscle pain. To evaluate the disease burden in the population and the effectiveness of public health measures, periodic seroprevalence surveys are essential. Chikungunya outbreaks were reported from many Asian countries since 2005, after more than three decades of disappearance. The study aimed to estimate the seroprevalence of the chikungunya virus in southern parts of Karnataka state, through demonstrating chikungunya virus-specific neutralizing antibodies. A cross-sectional study was carried out using 509 archived blood samples from a hospital-based acute febrile illness surveillance project, representative of the period between June 2014 and 2018. The study reported a 3.7% seroprevalence of chikungunya virusneutralizing antibodies in Thirthahalli and Hosanagara taluks of South Karnataka. The low prevalence of chikungunya-neutralizing antibodies indicates that a major population is unexposed and prone to future outbreaks. K E Y W O R D S chikungunya, CHIKV, microneutralization assay, seroprevalence

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“…CHIKV has been classified into three distinct genotypes: Asia; East/Central/South African (ECSA) and West African9. CHIK isolates identified in India during 1963, and 1973 belonged to Asian genotype; however, recent epidemics in Indian Ocean and Indian subcontinent were caused by virus of the Indian Ocean Lineage (IOL)9 which has emerged from ECSA genotype. The appearance of new genotypes of ECSA strains was resulted due to microevolutionary changes in the CHIKV genome10.…”

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confidence: 99%

“…Full genome sequencing and phylogenetic analysis of CHIKV isolate were performed using MEGA5.1 ( https://mega.software.informer.com/5.1 ) with the neighbour-joining method9. Comparative amino acid analysis was also performed using the CHIKV prototype (S27 East-Central South African) strain from Africa and the Karnataka 2006 strains (IOL group).…”

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confidence: 99%