Genetic characterization of Bacillus anthracis in Guizhou Province, Southwest of China

Li, Shijun; Ma, Qing; Chen, Hong; Wang, Dingming; Liu, Ying; Wei, Xiaoyu; Lv, You; Yao, Guanghai; Tian, Kecheng; Tang, Guangpeng

doi:10.1186/s12866-015-0414-8

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Some farming regions in China are in naturally infectious areas prone to anthrax outbreaks; livestock are commonly infected by B. anthracis during farming, so many recurrent animal anthrax cases are reported (17). Guizhou Province is a historical center of anthrax in China, and sporadic human anthrax epidemics have happened frequently in Guizhou Province in recent years (9,10,18,19). In this study, a case of suspected anthrax case was reported to the Guizhou Provincial CDC in September 2016.…”

Section: Discussionmentioning

confidence: 68%

Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China

Chen

et al. 2020

Front. Public Health

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Section: Discussionmentioning

confidence: 68%

Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China

Chen

et al. 2020

Front. Public Health

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“…Cutaneous anthrax is a zoonotic infection caused by the bacteria Bacillus anthracis, which is responsible for over 95% of all anthrax cases [11]. In China, the growth of the livestock industry and the rise in cattle and sheep farming have led to an increase in localized outbreaks of cutaneous anthrax, causing panic among people and imposing a signi cant burden on socioeconomic development [20][21][22][23]. Thus, the characteristics of concentrated cutaneous anthrax cases in endemic regions need to be analyzed, and effective treatment strategies need to be investigated for the diagnosis and management of this disease.…”

Section: Discussionmentioning

confidence: 99%

Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

luo,

Ma,

Zhou

et al. 2024

Preprint

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Background and ObAjectives: Anthrax is a global health concern, with cutaneous anthrax accounting for over 95% of cases and generally promising outcomes. Nonetheless, the absence of timely intervention can result in mortality rates of 10–40%. This research aims to explore the clinical presentations and phenotypic characteristics of cutaneous anthrax patients and evaluate the efficacy of various therapeutic approaches. Methods: A retrospective study was performed on 76 cutaneous anthrax patients identified at three hospitals from 2017 to 2022. Patients were categorized based on their hospital stay into two groups: those hospitalized for at least seven days and those for shorter durations. We assessed their clinical and phenotypic profiles, including symptoms, general health status, and laboratory findings, alongside treatment outcomes, focusing on hormone therapy and antibiotic regimens. Results: The study encompassed 76 diagnosed individuals, predominantly young adult males (78.9%). A significant gender disparity was noted. Hormonal treatment markedly improved edema regression in patients (P < 0.002), highlighting its therapeutic value. The impact of various antibiotic treatments on disease progression differed significantly based on hormone treatment status, with specific combinations showing more effectiveness in non-hormone-treated patients. Conclusions: The predominance of young male adults among cutaneous anthrax cases was observed, with early hormone treatment significantly reducing edema duration. In cases where hormone therapy is not utilized, employing piperacillin-tazobactam alone or in combination with quinolones effectively shortens the illness duration, suggesting a tailored approach to treatment can enhance patient outcomes.

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“…The main pathogenic bacteria in the genus Brucella are Brucella suis, B. melitensis and B. abortus. The brucellosis epidemic is mainly caused by B. melitensis in Guizhou Province [35]. Brucellosis has covered nine cities or states in Guiyang, Qiannan, Qiandongnan, Tongren, Zunyi, Qiannan, Liupanshui, Anshun, and Bijie as well as Gui'an New District [36], and the prevention and control situation is grim.…”

Section: Discussionmentioning

confidence: 99%

Detection of bacteria carried by ticks from the mountain areas of Guizhou, Southwestern China

Zhan,

Wu,

et al. 2023

Preprint

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Background: Emerging tick-borne bacterial pathogens pose a threat to public health. The bacterial community and diversity in ticks have been reported with high-throughput sequencing methods that have been widely used in microorganism identification. Tick-borne bacterial pathogens such as Rickettsia, Ehrlichia, Coxiella, and Bartonella amplified by PCR methods have been reported in Guizhou. Little information has been reported on the diversity of the bacterial community in ticks in the areas. The aim of this study was to explore the diversity of the bacterial community in ticks from Guizhou Province, southwestern China. Methods: Ticks were collected in the mountainous areas of three counties in Guizhou Province from 2019-2022. Tick species were identified by morphology and molecular biology. DNA was extracted from tick samples, followed by high-throughput sequencing of the full-length 16S rRNA gene to analyze the diversity of the bacterial community of ticks. Results: A total of 554 ticks were captured, including 453 Rhipicephalus microplus and 101 Haemaphysalis longicornis, from cattle and sheep in Ziyun, Shibing, and Luodian Counties. In total, 823 operational taxonomic units (OTUs) were identified with 13 phyla, 22 classes, 55 orders, 121 families, and 253 genera of bacteria. The dominant bacterial genera were Staphylococcus, Pseudomonas, and Stenotrophomonas. We noticed that Rickettsia and Coxiella were abundant in the samples collected from Luodian County. Other tick-borne pathogens, such as Bartonella, Yersinia, Brucella, Anaplasma, and Francisella,were distinguished in the ticks. Conclusions: These results helped us to understand the diversity of the bacterial community in ticks in Guizhou mountain areas. Further studies are needed to uncover the pathogenicity of these tick-carried bacteria and their potential public health threats.

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Genetic characterization of Bacillus anthracis in Guizhou Province, Southwest of China

Cited by 7 publications

References 17 publications

Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China

Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China

Early Hormone Administration and Antibiotic Treatment is Key to Managing Cutaneous Anthrax

Detection of bacteria carried by ticks from the mountain areas of Guizhou, Southwestern China

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