Genetic characteristics of the course of chronic hepatitis

Abstract

The aim of the study was a comparative analysis of genotypic variants of TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the effect of TNF-α gene genotypes on the course of the disease indicates an increased risk of CVHC development with both moderate and highly active course of the disease in carriers of the G / A + A / A genotype combination. The data obtained allow us to conclude that the carriage of the “G” allele and the combination of genotypes A / G + G / G of the –A49G polymorphism of the CTLA-4 gene are associated not only with a decrease in the risk of CVHC development, but also with a lower intensity of inflammation and fibro-formation in the liver and a high probability of favorable course of the disease.