Genetic characterisation of attenuated SAD rabies virus strains used for oral vaccination of wildlife

Geue, Lutz; Schares, Susann; Schnick, Christina; Kliemt, Jeannette; Beckert, A.; Freuling, Conrad Martin; Conraths, Franz J.; Hoffmann, Bernd; Zanoni, Reto; Marston, Denise A.; McElhinney, L. M.; Johnson, Nicholas; Tordo, Noël; Müller, Thomas

doi:10.1016/j.vaccine.2008.04.007

Cited by 56 publications

(37 citation statements)

References 35 publications

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“…Accumulated data have shown that homologous recombination can occur between double-or negative-stranded RNA viruses that undergo "caged replication" (12,13,15,19,41,57). However, the mechanism resulting in homologous recombination in these viruses is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Intragenic Recombination as a Mechanism of Genetic Diversity in Bluetongue Virus

Ding

et al. 2010

J Virol

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Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unknown whether intragenic recombination can occur and contribute to the process in the virus. We present here several BTV groups containing mosaic genes to reveal that intragenic recombination can take place between the virus strains and play a potential role in bringing novel BTV lineages.

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Section: Discussionmentioning

confidence: 99%

Intragenic Recombination as a Mechanism of Genetic Diversity in Bluetongue Virus

Ding

et al. 2010

J Virol

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“…The Ministry of Health has reported 34 cases of human Rabies in 2015 with the maximum number (10) from Kurunegala (MOH Weekly Epidemiological Report), while a total number of 37 cases had been reported in 2012, with 1-5 cases distributed in many districts. (Geue et al, 2008;Tao et al, 2010;Wu et al, 2011). Rabies vaccines produced in compliance with OIE requirements protect against all variants of rabies virus including other phylogroup 1 lyssaviruses (Brookes et al, 2005).…”

Section: Anti-rabies Vacine (Arv)mentioning

confidence: 99%