Genetic Cause of Autosomal Recessive Hereditary Nephropathy in the English Cocker Spaniel

Davidson, Ashley G.; Bell, Rebecca; Lees, George E.; Kashtan, Clifford E.; Davidson, George S.; Murphy, Keith E.

doi:10.1892/0891-6640(2007)21[394:gcoarh]2.0.co;2

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…The Bernese mountain dog has an increased risk for immune-mediated glomerulonephritis, the English cocker spaniel for a glomerular basement membrane disorder, the soft-coated wheaten terrier for a podocytopathy and the cairn terrier for polycystic KD (McKenna and Carpenter 1980, Reusch and others 1994, Davidson and others 2007, Littman and others 2013). Dogs of the Doberman pinscher, Dalmatian and rottweiler breeds have been suggested to be at risk for glomerulopathies (Picut and Lewis 1987, Hood and others 2002b, Wakamatsu and others 2007).…”

Section: Discussionmentioning

confidence: 99%

Incidence of and mortality from kidney disease in over 600,000 insured Swedish dogs

et al. 2015

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Kidney disease is an important cause of morbidity and mortality in dogs. Knowledge about the epidemiology of kidney disease in the dog population is valuable and large-scale epidemiological studies are needed. The aim of the present study was to use insurance data to estimate kidney-related morbidity and mortality in the Swedish dog population. Insurance company data from insured dogs during the years 1995-2006 were studied retrospectively. Incidence and mortality were calculated for the whole group of dogs as well as divided by sex and breed. The total number of veterinary care insured dogs was 665,245. The total incidence of kidney disease in this group of dogs was 15.8 (15.3-16.2) cases/10,000 dog-years at risk. The number of dogs in the life insurance was 548,346 and in this group the total kidney-related mortality was 9.7 (9.3-10.2) deaths/10,000 dog-years at risk. The three breeds with the highest incidence of kidney disease were the Bernese mountain dog, miniature schnauzer and boxer. The three breeds with the highest mortality caused by kidney disease were the Bernese mountain dog, Shetland sheepdog and flat-coated retriever. In conclusion, the epidemiological information provided in this study concerning kidney disease in dogs can provide valuable information for future research.

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Section: Discussionmentioning

confidence: 99%

Incidence of and mortality from kidney disease in over 600,000 insured Swedish dogs

et al. 2015

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“…Different types of canine inherited renal diseases have been described in the Bull Terrier [ 7 ], Cocker Spaniel [ 8 , 9 , 10 , 11 , 12 ], Samoyed [ 13 , 14 ], Shih Tzu [ 15 ], Soft Coated Wheaten Terrier [ 16 , 17 ], Navasota [ 18 ], English Springer Spaniel [ 19 ] and Bernese Mountain Dog [ 20 , 21 ]. Canine inherited renal diseases mostly affecting the glomeruli have been reported in the Doberman Pinscher [ 22 , 23 ], Newfoundland [ 24 ] and Bullmastiff [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Histopathological Features of Renal Maldevelopment in Boxer Dogs: A Retrospective Case Series (1999–2018)

Cavalera

Gernone

Uva

et al. 2021

Animals

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Renal maldevelopment (RM) has been proposed to replace the old and sometimes misused term “renal dysplasia” in dogs. Although renal dysplasia has been described in Boxers, hereditary transmission has only been hypothesized. This study reports clinical and renal histological findings in Boxer dogs with RM, proposing a possible mode of inheritance. Medical records of 9 female Boxer dogs, older than 5 months and with a clinical diagnosis of chronic kidney disease prior to one year of age, were retrospectively reviewed. Polyuria and polydipsia (PU/PD), decreased appetite, weight loss, lethargy and weakness were described in all affected dogs. Common laboratory findings were proteinuria, diluted urine, non-regenerative anemia, azotemia, hyperphosphatemia, hypoalbuminemia and hypercholesterolemia. Histopathology of the kidneys revealed the presence of immature glomeruli in all dogs, which is consistent with RM. In 7 related dogs, the pedigree analysis showed that a simple autosomal recessive trait may be a possible mode of inheritance. Renal maldevelopment should be suspected in young Boxer dogs with a history of PU/PD, decreased appetite, weight loss, lethargy, weakness and proteinuria. Due to its possible inheritance, an early diagnosis of RM may allow clinicians to promptly identify other potentially affected dogs among the relatives of the diagnosed case.

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“…Most of these diseases are progressive and eventually fatal, and the primary renal defect and underlying mode of inheritance are mostly unknown. Hereditary nephritis (HN) in English Cocker Spaniels, 11 Samoyeds, 12 and mixed breed dogs from Navasota 13 is the only progressive JGN with a defined molecular genetic basis. HN refers to a group of genetic disorders in which an inherited defect of type IV collagen in glomerular basement membranes (GBM) causes progressive glomerular disease 14–16 .…”

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confidence: 99%

Progressive Juvenile Glomerulonephropathy in 16 Related French Mastiff (Bordeaux) Dogs

Lavoué

Lugt

Day

et al. 2010

Journal of Veterinary Internal Medicine

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Background: Familial juvenile glomerulonephropathy (JGN) is reported in several breeds of dogs. The mode of inheritance and spectrum of pathological lesions vary among breeds. A progressive JGN was detected in a pedigree of French Mastiff (FM) dogs.Objectives: To describe clinical, laboratory, and histopathologic findings in related FM dogs suffering from progressive JGN and to determine the mode of inheritance of this condition.Animals: Sixteen affected and 35 healthy related FM dogs Methods: FM dogs o24 months of age and diagnosed with chronic kidney disease with evidence of proteinuria entered the study. Clinical, laboratory, histopathologic findings, and pedigree data were recorded.Results: Clinical signs were typical of progressive glomerulopathy with resultant renal failure. Increased blood urea nitrogen, creatinine and total cholesterol concentrations, and proteinuria were found in all patients. Affected dogs had abnormal kidney structure on abdominal ultrasound examination. Histopathologic examination revealed extensive cystic glomerular atrophy, glomerular hypercellularity, and capillary wall thickening without immune complex deposition when tested with immunohistochemistry or immunofluorescence. Electron microscopy did not disclose specific primary glomerular lesions. Mean age at death was 20 months and mean length of survival after diagnosis was 6 months. Both males and females from healthy parents were affected. An autosomal recessive mode of transmission is suspected, but a more complex mode of inheritance cannot be excluded.Conclusions and Clinical Importance: Progressive familial JGN occurs in FM dogs. Characterization of the pathogenesis and mode of inheritance of this disease warrants additional study.

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Genetic Cause of Autosomal Recessive Hereditary Nephropathy in the English Cocker Spaniel

Cited by 16 publications

References 25 publications

Incidence of and mortality from kidney disease in over 600,000 insured Swedish dogs

Incidence of and mortality from kidney disease in over 600,000 insured Swedish dogs

Clinical and Histopathological Features of Renal Maldevelopment in Boxer Dogs: A Retrospective Case Series (1999–2018)

Progressive Juvenile Glomerulonephropathy in 16 Related French Mastiff (Bordeaux) Dogs

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