Genetic basis of procoagulant and fibrinolytic perioperative adverse events

Spiess, Bruce D.; Chandler, Wayne L.

doi:10.1053/bean.2001.0152

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…[8][9][10] Coagulation factors are produced primarily in the liver and at the vascular endothelium; PAI-1 is produced by the liver, adipose tissue and endothelial cells whereas AT-III is produced exclusively in the liver. 21,22 vWf is produced and secreted by the endothelium. 23 Modest improvements in a number of coagulation factor profiles have previously been reported in patients with type 2 diabetes receiving other insulin-sensitising agents, including the biguanide metformin.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of pioglitazone versus gliclazide on hepatic and humoral coagulation factors in patients with type 2 diabetes

Perriello

Pampanelli

Brunetti

et al. 2007

Diabetes and Vascular Disease Research

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This study compared the long-term effects of pioglitazone and gliclazide on the production of coagulation factors in patients with type 2 diabetes. Patients (n=283) with glycosylated haemoglobin > 7.5% were randomised to receive either pioglitazone (30-45 mg/day) or gliclazide (80-320 mg/day) for one year. Coagulation factors were measured at baseline and at six and 12 months. While both pioglitazone and gliclazide induced a comparable improvement in glycaemic control, only pioglitazone improved insulin sensitivity. Pioglitazone significantly (p < or = 0.001) decreased circulating levels of von Willebrand factor (-9.7%, -9.4%) and plasminogen activator inhibitor-1 (-16.8 ng/ml, -12.3 ng/ml), and increased levels of antithrombin-III (+1.3 mg/dL, +1.5 mg/dL) after six and 12 months, respectively. The beneficial effects of pioglitazone on glycaemic control, lipid homeostasis, and coagulation and thrombosis, may improve vascular outcomes in patients with type 2 diabetes.

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