Genetic basis, evolutionary origin and spread of resistance to herbicides inhibiting acetolactate synthase in common groundsel (<i>Senecio vulgaris</i>)

Délye, Christophe; Causse, Romain; Michel, Séverine

doi:10.1002/ps.4058

Cited by 24 publications

(32 citation statements)

References 43 publications

(78 reference statements)

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“…More importantly, several title compounds also showed good weed inhibition against resistant D. sophia. Among these compounds, 8,11,17,18,20,21,22,23, and 28 obviously showed more than 60% inhibition in controlling the growth of the resistant weed at the highest applied concentration. Compounds 25, 26, and 27 displayed almost complete weed control, which was more powerful than that of tribenuron-methyl.…”

Section: Herbicidal Activitymentioning

confidence: 99%

“…IMIs, TPs, SUs, and SCTs. [21][22][23] However, the mutation of the aforementioned residues has exceptionally induced a weak weed resistance (resistance factor < 10-fold). In a previous study of this lowresistance mechanism, we discovered that the flexibility of the oxygen linker of bispyribac could make the ligand adapt to the change of the binding pocket after mutation.…”

Section: Introductionmentioning

confidence: 99%

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Fragment‐based discovery of flexible inhibitor targeting wild‐type acetohydroxyacid synthase and P197L mutant

Yang

Chen

et al. 2020

Pest Management Science

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BACKGROUND Intensifying weed resistance has challenged the use of existing acetohydroxyacid synthase (AHAS)‐inhibiting herbicides. Hence, there is currently an urgent requirement for the discovery of a new AHAS inhibitor to effectively control AHAS herbicide‐resistant weed species produced by target mutation. RESULTS To combat weed resistance caused by AHAS with P197L mutation, we built a structure library consisting of pyrimidinyl‐salicylic acid derivatives. Using the pharmacophore‐linked fragment virtual screening (PFVS) approach, hit compound 8 bearing 6‐phenoxymethyl substituent was identified as a potential AHAS inhibitor with antiresistance effect. Subsequently, derivatives of compound 8 were synthesized and evaluated for their inhibitory activities. The study of the enzyme‐based structure–activity relationship and structure−resistance relationship studies led to the discovery of a qualified candidate, 28. This compound not only significantly inhibited the activity of wild‐type Arabidopsis thaliana (At) AHAS and P197L mutant, but also exhibited good antiresistance properties (RF = 0.79). Notably, compared with bispyribac at 37.5–150 g of active ingredient per hectare (g a.i. ha–1), compound 27 exhibited higher growth inhibition against both sensitive and resistant Descurainia sophia, CONCLUSION The title compounds have great potential to be developed as new leads to effectively control herbicide‐resistant weeds comprising AHAS with P197L mutation. Also, our study provided a positive case for discovering novel, potent and antiresistance inhibitors using a fragment‐based drug design approach.

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Section: Herbicidal Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fragment‐based discovery of flexible inhibitor targeting wild‐type acetohydroxyacid synthase and P197L mutant

Yang

Chen

et al. 2020

Pest Management Science

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“…Information regarding genetic sequences of target enzymes and mutations conferring resistance is becoming more available. However, there is still little known about the other mechanisms of resistance (Shergill et al ., ; Délye et al ., ). Determining the expression profiles of genes potentially involved in the development of herbicide resistance in weeds may help characterise the mechanisms of resistance unrelated to point mutations.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of six commonly used reference genes for gene expression studies in herbicide‐resistant Avena fatua biotypes

Wrzesińska

Kierzek

Obrępalska‐Stęplowska

2016

Weed Research

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Summary Avena fatua of the family Poaceae is one of the most common and economically damaging grass weeds. Resistance to herbicides that inhibit acetyl‐coenzyme A carboxylase and acetolactate synthase activities has recently been detected in A. fatua. The resistance may be due to mutations in the herbicide targets and/or enhanced herbicide metabolism resulting from changes in gene expression, including in genes involved in detoxifying herbicide active ingredients. To analyse gene expression, stable housekeeping genes must be experimentally determined and used for data normalisation. In this study, A. fatua plants were treated with different herbicide types and plant materials were harvested at three time points following treatment. Six candidate reference genes (18S rRNA, ACT, EF1α, GAPDH, TBP, and TUB) were selected, sequenced and analysed by RT‐qPCR. The resulting data were assessed using four algorithms from the RefFinder software to determine gene expression stability. We identified TBP and GAPDH as the most stably expressed A. fatua reference genes following herbicide treatment.

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“…We suggest that special attention should be paid to the plain in NE China and Shandong Peninsula, where modern agriculture has developed well. Senecio vulgaris tend to invade agriculture area and the frequent use of herbicide may screen the herbicide biotype (Délye et al 2015). Both of these two trait will bring disadvantage effect on modern agriculture.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous cases of triazineresistant S. vulgaris have been reported in Europe, North America and South America, and genetice researdch showed this kind of herbicide-resistance evolved by multiple, independent appearances of mutant alleles followed by spread (Délye et al 2015;Salzmann et al 2008). …”

Section: Introductionmentioning

confidence: 99%

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Supplemental Information 1: Senecio Vulgaris’ Occurrences Records in China

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Predicting potential distribution for alien plants by species distribution model (SDM, or Ecological Niche Model) using occurrence data and habitat environmental variables plays an important role in management of the invasive risk by an alien plant. Common groundsels (Senecio vulgaris, Asteracea), native in Eurasia and North Africa, has been a cosmopolitan weed in temperature and also listed as one of invasive plants in China. We predict the potential distribution of this species in the world and in China particularly in Maxent (maximum entropy) models by using global occurrence records of S. vulgaris and the associated climate variables. The occurrence data were collected from the online databases, Global Biodiversity Information Facility database (GBIF), Chinese Virtual Herbarium database (CVH), and also from field work in China. The climate variables were download from WorldClim (http://www.worldclim.org). The occurrence records showed that S. vulgaris is present in 16 provinces or regions in north -eastern, south -western, central and north China, and almost not present in southeastern, north -western China. The mapping of S. vulgaris potential distribution is diagonally across China, including the north -eastern, south -western China, and the cool area between the two regions. Analysis of the contribution and importance of climatic factors in the prediction model indicated that S. vulgaris adapts to the climate in humid and cool area in China (annual mean temperature ranges 2.4 -17.5 ℃, and annual precipitation ranges 550 -1500 mm). It is suggested that special attention should be paid to the plain in NE China and Shandong Peninsula, Yungui Plateau, the cool mountain area around Sichuan basin, in western Hubei, southern Shaanxi, Shanxi and around Beijing in order to manage the invasion risk by S. vulgaris. The better performance of the model built by using occurrence data in China than that by using the global data in relation the predict outcome in China imply that it is might be better to use regional data than the global data when predict potential distribution for an alien plant with long invasive history in study area.

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Genetic basis, evolutionary origin and spread of resistance to herbicides inhibiting acetolactate synthase in common groundsel (Senecio vulgaris)

Abstract: Synthesis of strigolactones, a strategic account 15 B Zwanenburg (The Netherlands, Czech Republic), S Ćavar Zeljković and T Pospíšil (Czech Republic) Review Plant disease management in organic farming systems 30 AHC van Bruggen (USA), A Gamliel (Israel) and MR Finckh (Germany)

Cited by 24 publications

References 43 publications

Fragment‐based discovery of flexible inhibitor targeting wild‐type acetohydroxyacid synthase and P197L mutant

Fragment‐based discovery of flexible inhibitor targeting wild‐type acetohydroxyacid synthase and P197L mutant

Evaluation of six commonly used reference genes for gene expression studies in herbicide‐resistant Avena fatua biotypes

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