Genetic Bases for Predisposition to Common Multifactorial Disease in Man. Part II

Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II.In vivostudies

“…Of course, as in all diseases with multifactorial genesis, the presence of an additional risk factor does not mean that the individual will definitely develop the disease or condition, only that in its presence the risk is increased compared to the general population. [ 38 ] Considering that the factors disrupting the circadian rhythm are very common, especially in industrialized countries (light at night, insufficient lighting during the day, evening and night shift work and/or rotating shifts, major meal for the day consumed in the evening hours, frequent transmeridional flights, etc. ), it could be expected that the health impact would continue to increase in the future.…”

“…having more regular checkups). [ 44 ] Medical personnel are, on the whole, more likely to stick to the study from the beginning to the end, fill the questionnaires accurately (because of pre-existing knowledge about the problem under study) and have their medical checkups regularly, allowing for early diagnosis and more precise risk assessment. In a 2007 press release the International Agency for research on Cancer (IARC) pronounced that ‘…Shiftwork that involves circadian disruption is probably carcinogenic to humans…’ [ http://www.iarc.fr/en/media-centre/pr/2007/pr180.html] .…”