Genetic associations of body composition, flexibility and injury risk with ACE, ACTN3 and COL5A1 polymorphisms in Korean ballerinas

Abstract

[Purpose]The purpose of this study was to exam the association of body composition, flexibility, and injury risk to genetic polymorphisms including ACE ID, ACTN3 RX, and COL5A1 polymorphisms in ballet dancers in Korea.[Methods]For the purpose of this study, elite ballerinas (n = 97) and normal female adults (n = 203) aged 18 to 39 were recruited and these participants were tested for body weight, height, body fat, fat free mass, flexibility, injury risks on the joints and gene polymorphisms (ACE, ACTN3, COL5A1 polymorphism).[Results]As results, the ACE DD genotype in ballerinas was associated with higher body fat and percentage of body fat than the ACE II and ID genotypes (p < 0.05). In the study on the ACTN3 polymorphism and ballerinas, the XX genotype in ballerinas had lower body weight and lower fat-free mass than the RR and RX genotype (p < 0.005). Also, the means of sit and reach test for flexibility was lower in the ACTN3 XX genotype of ballerinas than the RR and RX genotype of ballerinas (p < 0.05). Among the sports injuries, the ankle injury of the XX-genotyped ballerinas was in significantly more prevalence than the RR and XX-genotyped ballerinas (p < 0.05). According to the odd ratio analysis, XX-genotyped ballerinas have the injury risk on the ankle about 4.7 (95% CI: 1.6~13.4, p < 0.05) times more than the RR and RX-genotyped ballerinas. Meanwhile, the COL5A1 polymorphism in ballerinas has no association with any factors including flexibility and injury risks.[Conclusion]In conclusion, ACE polymorphism and ACTN3 polymorphism were associated with ballerinas' performance capacity; COL5A1 was not associated with any factors of performance of Ballerinas. The results suggested that the ACE DD genotype is associated with high body fat, the ACTN3 XX genotype is associated with low fat-free mass, low flexibility, and higher risk of ankle-joint injury.

Alpha-actinin-3 R577X Polymorphism Profile of Turkish Professional Hip-Hop and Latin Dancers

“…Like our findings, Kim et al (2014) polymorphisms including ACE ID, ACTN3 RX, and COL5A1 polymorphisms in Korean ballet dancers and reported that ACE ID and ACTN3 RX polymorphisms were related with ballerinas' physical performance. In their study, they analyzed 97 elite ballerinas and 203 controls and showed that 55.7% of their ballerinas had the RX genotype (8).…”

“…In their study, they analyzed 97 elite ballerinas and 203 controls and showed that 55.7% of their ballerinas had the RX genotype (8).…”

“…Despite some studies trying to associate the genetic parameters in dancers (8,9), studies including genetic polymorphisms effecting physical properties and professional dancers are very limited. The aim of this study was to determine the genotype and allele distribution of ACTN3 R577X polymorphism in Turkish professional dancers and assess the impact of this polymorphism on dancing activity.…”

The association between body-built and injury occurrence in pre-professional ballet dancers – Separated analysis for the injured body-locations

“…Therefore, the results of the analyses where we have defined associations between the body-built indices and injury-prevalence on different locations are particularly interesting. Most of the studies done so far examined the general prevalence of injury in relation to anthropometric and body-built indices [6,23]. The strength of the current study is that, to our knowledge, it is the first to examine how the body-built is potentially related to an isolated injury of DISCUSSION There were several most important findings of this study.…”

“…However, the injuries at 3 locations (ankle, foot and toes) were specifically related to the body-built. The previous research found a positive association between body-fat measures and injury occurrence in ballet and dancing [23]. While an endomorphic somatotype component explained the fatness and roundness of the body, the results of higher ankle-injury prevalence of those ballet dancers who have higher endomorphic component were therefore expected.…”