Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos

Zhang, Yuan; Elgart, Michael; Granot‐Hershkovitz, Einat; Wang, Heming; Tarraf, Wassim; Ramos, Alberto R.; Stickel, Ariana; Zeng, Donglin; Garcia, Tanya P.; Testai, Fernando D.; Wassertheil‐Smoller, Sylvia; Isasi, Carmen R.; Daviglus, Martha L.; Kaplan, Robert C.; Fornage, Myriam; DeCarli, Charles; Redline, Susan; González, Hector M.; Sofer, Tamar

doi:10.1016/j.ebiom.2022.104393

Cited by 12 publications

(9 citation statements)

References 63 publications

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“…In this framework, GWAS SNPs genetic pre‐disposition to insomnia were found to have a significant causal effect on the risk of some mental conditions such as major depression, bipolar disorder type II, schizophrenia, autism spectrum disorder, alcohol, nicotine and opioid use, attention‐deficit/hyperactivity disorder, anxiety and post‐traumatic stress disorder (PTSD), and suicidal behaviours with reverse causality observed for major depression, nicotine use, and PTSD only (Jansen, Dolinoy, et al, 2019, Jansen, Watanabe, et al, 2019; Gao et al, 2019; Song et al, 2020; Pasman et al, 2020; Lewis et al, 2020; Cai et al, 2021; Huang et al, 2021; Carpena et al, 2021; Watanabe et al, 2022; Sun et al, 2022; Baranova et al, 2022; Zhou et al, 2022; Nassan et al, 2022). Similarly, GWAS SNPs genetic pre‐disposition to insomnia were found to have a significant causal one‐way effect on the risk of some medical conditions including: coronavirus disease 2019 (COVID‐19) susceptibility (Peng et al, 2022), cognitive impairment, neurodegenerative conditions (Sun et al, 2020; Zhang et al, 2022), cardiovascular diseases (Jansen, Dolinoy, et al, 2019; Jansen, Watanabe, et al, 2019; Jia et al, 2022; Liu et al, 2021; Zheng et al, 2020), diabetes, cardio‐metabolic risks (Gao et al, 2020; Jansen, Dolinoy, et al, 2019; Jansen, Watanabe, et al, 2019; Liu et al, 2021; Liu et al, 2022), increasing the odds of reporting pain conditions (An et al, 2022; Broberg et al, 2021; Chu et al, 2021; Shu et al, 2022) and for other medical conditions (Bao et al, 2022; He et al, 2022; Huo et al, 2021; Zha et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

Palagini

Geoffroy

Gehrman

et al. 2023

Journal of Sleep Research

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SummaryInsomnia is a stress‐related sleep disorder conceptualised within a diathesis‐stress framework, which it is thought to result from predisposing factors interacting with precipitating stressful events that trigger the development of insomnia. Among predisposing factors genetics and epigenetics may play a role. A systematic review of the current evidence for the genetic and epigenetic basis of insomnia was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) system. A total of 24 studies were collected for twins and family heritability, 55 for genome‐wide association studies, 26 about candidate genes for insomnia, and eight for epigenetics. Data showed that insomnia is a complex polygenic stress‐related disorder, and it is likely to be caused by a synergy of genetic and environmental factors, with stress‐related sleep reactivity being the important trait. Even if few studies have been conducted to date on insomnia, epigenetics may be the framework to understand long‐lasting consequences of the interaction between genetic and environmental factors and effects of stress on the brain in insomnia. Interestingly, polygenic risk for insomnia has been causally linked to different mental and medical disorders. Probably, by treating insomnia it would be possible to intervene on the effect of stress on the brain and prevent some medical and mental conditions.

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Section: Resultsmentioning

confidence: 99%

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

Palagini

Geoffroy

Gehrman

et al. 2023

Journal of Sleep Research

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“…Contrastingly, previous findings mainly aimed to explore the impact of OSA on cognitive performance. For instance, Zhang et al estimated associations between Polygenic Risk Scores for OSA and cognitive function in Hispanic/Latino adults, and found that PRS for OSA was not associated with cognitive outcomes [ 21 ]. A recent meta-analysis revealed neurocognitive deficits were evident in children with OSA [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, traditional observational studies exhibit limitations such as small sample sizes, inconsistent results, existing confounding factors, and measurement errors. Given the increase in OSA prevalence with aging, environmental confounding, such as socioeconomic status, lifestyle habits, smoking, drinking, and obesity, might impede the ability of researchers to explore the causal association by traditional observational studies [ 10 , 21 ]. It is difficult to make causal inferences based on these observational studies due to possible confounders and reverse causality.…”

Section: Introductionmentioning

confidence: 99%

Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance

Bao,

Zhao,

Qin

et al. 2024

BMC Psychiatry

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Background Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined. Methods We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published meta-analysis studies. Linkage disequilibrium score regression analysis was employed to reveal genetic correlations between OSA and related traits. Results Our MR study provided evidence that OSA was found to significantly increase the volume of the hippocampus (IVW β (95% CI) = 158.997 (76.768 to 241.227), P = 1.51e-04), with no heterogeneity and pleiotropy detected. Nominally causal effects of OSA on brain structures, such as the thickness of the temporal pole with or without global weighted, amygdala structure change, and cerebellum white matter change covering lifespan, were observed. Bidirectional causal links were also detected between brain cortical structure, brain subcortical, cognitive performance, and OSA risk. LDSC regression analysis showed no significant correlation between OSA and hippocampus volume. Conclusions Overall, we observed a positive association between genetically predicted OSA and hippocampus volume. These findings may provide new insights into the bidirectional links between OSA and neurocognitive features, including brain morphology and cognitive performance.

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“…However, the complex relationship between sleep and cognitive performance still needs further study. Over the years, much literature has emerged on the relationship between sleep and cognitive function [7][8][9][10][11][12][13]. However, the result is controversial.…”

Section: Introductionmentioning

confidence: 99%

“…However, the result is controversial. In previous studies, some scholars pointed out that short and long sleep may be related to cognitive decline [12][13][14][15], while others put forward the opposite view [9][10][11]. One of the studies on diabetic patients pointed out that the length of sleep may play a unique role in this group [16].…”

Section: Introductionmentioning

confidence: 99%

Association of Sleep Duration with Cognitive Performance in the Elderly: A Cross-Sectional Study from National Health and Nutrition Examination Survey (NHANES)

Wu,

Yuan

2024

Preprint

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Background The incidence of cognitive dysfunction and nervous system diseases is increasing with the aging trend, which has become an essential challenge in the global health field. This study aims to explore the relationship between sleep duration and cognitive performance, paying particular attention to the influence of sleep duration in different populations. Methods The National Health and Nutrition Survey data from 2011 to 2014 were used to evaluate the relationship between sleep duration and cognitive performance. Cognitive performance was assessed by three tests: Alzheimer's Disease Registration Association (CERAD), Animal Fluency (AF), and Digital Symbol Substitution Test (DSST). The weighted multivariate logistic regression model verified the relationship between sleep duration and cognitive performance. A restricted cubic spline model was used to determine the nonlinear relationship between sleep duration and cognitive performance. Results Of a total of 19931 patients, 2582 patients were included. Our study found a significant positive correlation between prolonged sleep (more than 9 hours per night) and cognitive decline (multivariate-adjusted OR = 1.50,95%CI:1.10 ~ 2.05). In contrast, short periods of sleep (less than seven hours per night) showed no significant correlation in cognitive function. Participants who slept moderately (7–9 hours per night) performed better on cognitive tests, with higher CERAD, AFT, and DSST scores. The association findings highlight the possible effects of sleep on cognitive health, especially in older people. Conclusion This study emphasizes that long sleep may be related to the decline of cognitive function in the elderly. Future research should explore the physiological mechanism and potential causes of sleep and cognitive function to support the maintenance of cognitive health in the elderly more scientifically.

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Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos

Cited by 12 publications

References 63 publications

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance

Association of Sleep Duration with Cognitive Performance in the Elderly: A Cross-Sectional Study from National Health and Nutrition Examination Survey (NHANES)

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