Genetic Association Studies of Antioxidant Pathway Genes and Schizophrenia

Chowdari, Kodavali V.; Bamne, Mikhil; Nimgaonkar, Vishwajit L.

doi:10.1089/ars.2010.3508

Cited by 50 publications

(34 citation statements)

References 78 publications

(66 reference statements)

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“…Despite the inherent complexity of this area of research, with significant heterogeneity in results and negative studies, a constellation of key findings support an association between oxidative stress and the pathophysiology of schizophrenia. Genes involving antioxidant defenses are associated with increased risk of schizophrenia (2). Abnormal oxidative stress parameters have been reported in peripheral blood (3), red blood cells (RBCs) (4), neutrophils (5), platelets (6), cerebrospinal fluid (7), and postmortem brain (8) in patients with schizophrenia.…”

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confidence: 99%

Meta-Analysis of Oxidative Stress in Schizophrenia

Flatow

Buckley

Miller

2013

Biological Psychiatry

409

319

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Background Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis. Methods We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information, and the reference lists of identified studies. Results Forty-four studies met the inclusion criteria. Total antioxidant status seemed to be a state marker, because levels were significantly decreased in cross-sectional studies of serum and plasma in first-episode psychosis (FEP) and significantly increased in longitudinal studies of antipsychotic treatment for acute exacerbations of psychosis (p < .01 for each). The RBC catalase and plasma nitrite seemed to be state-related markers, because levels in cross-sectional studies were significantly decreased in FEP (p < .01) and significantly increased in stable outpatients (p = .01). In contrast, RBC superoxide dismutase seemed to be a trait marker for schizophrenia, because levels in cross-sectional studies were significantly decreased in acutely relapsed inpatients, FEP, and stable outpatients (p < .01 for each). Conclusions Oxidative stress abnormalities in FEP suggest an effect that might be independent of antipsychotic medications. Although some parameters (total antioxidant status, RBC catalase, and plasma nitrite) might be state markers for acute exacerbations of psychosis, others (RBC superoxide dismutase) might be trait markers; however, more longitudinal studies are needed. Our findings suggest that oxidative stress might serve as a potential biomarker in the etiopathophysiology and clinical course of schizophrenia.

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confidence: 99%

Meta-Analysis of Oxidative Stress in Schizophrenia

Flatow

Buckley

Miller

2013

Biological Psychiatry

409

319

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“…Like other genetically complex disorders, linkage studies in schizophrenia have been relatively unsuccessful. Later studies investigated ''positional candidates,'' that is, genes localized to linked regions that are expressed in the brain and plausibly have a role in pathogenesis of schizophrenia, reviewed in this Forum by Chowdari et al (8), yielding several positional candidates: Dysbindin (DTNBP1), Neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), and G72 (also named D-amino acid oxidase activator [DAOA]) (26).…”

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confidence: 99%

“…Genetic association studies have been conducted with polymorphisms in some of these genes, reviewed by Chowdari et al (8). They review GSH synthesis genes, GSH-related genes (GSTM1, GSTP1, GSTO1, GSTT1, and GSTT2), manganese SOD (MnSOD), and peptide methionine sulfoxide reductase (MSRA).…”

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confidence: 99%

“…For example, using parallel transcriptomics, proteomics, metabolomics approach, and hierarchical clustering, Prabakaran et al (19) identified 59 genes related mainly to mitochondria and energy metabolism. The review by Chowdari et al (8) suggests several promising candidate genes and suggestive genetic associations. For example, the associations with NOS1, MnSOD, and MSRA, in conjunction with the reported cellular studies and the published clinical studies of schizophrenia suggest a pathogenic role for the related protein products.…”

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confidence: 99%

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Oxidative Stress in Schizophrenia: Pathogenetic and Therapeutic Implications

Yao

Reddy²

2011

Antioxidants & Redox Signaling

110

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Over a century, a wide-ranging variety of pathophysiological models and causal hypotheses have been conceptualized for schizophrenia. One among these is the role for free radical-mediated pathology in schizophrenia, indicating impaired antioxidant defense system (AODS) and presence of oxidative stress in patients with schizophrenia. For the past two decades, the whole investigative domain of AODS and oxidative stress has broadened to include the wider AODS components, direct central nervous system assays of AODS, chemical imaging studies, proteomics, genetics of AODS, and, of importance to sufferers of schizophrenia, antioxidant therapeutics. These are some of the perspectives that are reviewed by several articles in this Forum. Overall, there has been growing recognition of the importance of oxidative stress in the pathophysiology of schizophrenia and in treatment-related side effects. The totality of the evidence from biochemistry, metabolomics, proteomics, genetics, and in vivo brain imaging points to the presence of multifarious abnormalities in the AODS and redox signaling in schizophrenia.

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“…14 Glutathione S-transferases (GSTs) are a family of prokaryotic and eukaryotic Phase II metabolic isozymes that provide critical defense against toxicants. 15,16 GSTs are expressed in many tissues in the human body. Previous studies have reported that GST levels of prefrontal cortex, peripheral blood, and cerebrospinal fluid were decreased in patients with SCZ, and suggested that GSTs play an important role in the development of SCZ.…”

Section: Introductionmentioning

confidence: 99%

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

Yan¹,

Duan²,

Fu³

et al. 2020

NDT

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Background: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations. Purpose: This case-control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population. Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes. Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008). Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.

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Genetic Association Studies of Antioxidant Pathway Genes and Schizophrenia

Cited by 50 publications

References 78 publications

Meta-Analysis of Oxidative Stress in Schizophrenia

Meta-Analysis of Oxidative Stress in Schizophrenia

Oxidative Stress in Schizophrenia: Pathogenetic and Therapeutic Implications

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

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