Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population

Zhou, Liting; Zheng, Dongchun; Wang, Shuyue; Zhu, Jian; Jia, Yiyang; Sun, Daisy; Xu, Jin; Wang, Qi; Chen, Huaiji; Xu, Feng; Li, Bo; Lin, Ye

doi:10.1186/s40064-016-3177-2

Cited by 7 publications

(3 citation statements)

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“…Genotypes and alleles of rs1927907 SNP had no significant association with AMD susceptibility. Present results were confirmed with the study reported by Zhou et al [33] Yu et al demonstrated that chronic periodontitis patients carrying rs1927907 SNP had higher susceptibility for chronic obstructive pulmonary disease. [34]…”

Section: Discussionsupporting

confidence: 92%

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

Xiong²

2019

Medicine

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The study was designed to reveal the relationship of toll-like receptor 4 ( TLR4, rs1927914 and rs1927907) polymorphisms with risk of age-related macular degeneration (AMD), as well as the adjustment of this association by some environmental and lifestyle factors in Chinese Han population. TLR4 polymorphisms were genotyped by polymerase chain reaction-restricted fragment length polymorphisms and direct sequencing method in 138 AMD patients and 146 healthy controls. Genotype distribution in the control group was checked with Hardy–Weinberg equilibrium. Association of TLR4 polymorphisms and AMD risk was evaluated by χ 2 test and adjusted by age and sex, smoking and drinking. Odds ratio (OR) with 95% confidence interval (95% CI) was used to represent the association strength. Logistic regressive analysis was used to calculate the adjusted OR values. CC genotype of rs1927914 had significantly lower frequency in AMD patients ( P = .010), indicated a negative association with AMD risk (crude: OR = 0.358, 95% CI = 0.162–0.791; adjusted: OR = 0.355, 95% CI = 0.160–0.789). C allele of rs1927914 might decrease the susceptibility of AMD (crude: OR = 0.698, 95% CI = 0.497–0.982; adjusted: OR = 0.698, 95% CI = 0.495–0.984). No significant association has been discovered between TLR4 rs1927907 polymorphism and AMD susceptibility. Strong linkage disequilibrium existed between rs1927914 and rs1927907 polymorphisms. C-C haplotype was negatively associated with AMD risk (OR = 0.242, 95% CI = 0.121–0.485; OR = 0.242, 95% CI = 0.120–0.488). CC genotype and C allele of rs1927914 were significantly associated with the decreased AMD susceptibility.

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Section: Discussionsupporting

confidence: 92%

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

Xiong²

2019

Medicine

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“…Besides rs4986790 and rs4986791, the association between CAD and other TLR4 genetic variants, including rs11536889, rs10116253 and rs10983755, have also been evaluated by genetic studies. 40 However, due to the limited published data, we were unable to include these variants in the present meta-analysis. Second, although Egger's and Beggs' tests and funnel plots did not reveal any evidence of publication bias, we could not exclude the possibility that some case-control studies obtaining negative results might not be published in peer-reviewed journals.…”

Section: Discussionmentioning

confidence: 99%

Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis

Sheng

2019

Adv Clin Exp Med

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Association of coronary artery disease with tolllike receptor 4 genetic variants: A meta-analysis. AbstractBackground. Toll-like receptor 4 (TLR4) plays an important role in the formation of coronary atherosclerotic plaque and the pathogenesis of coronary artery disease (CAD).Objectives. The aim of the study was to conduct a meta-analysis assessing the relationship between 2 common genetic variants in the TLR4 gene (rs4986790 and rs4986791) and susceptibility to CAD. Material and methods.A systematic search of Web of Science, Embase, Scopus, PubMed, and Wanfang Med Online was undertaken. Case-control studies assessing the association of rs4986790 and rs4986791 with CAD risk were included. The odds ratio (OR) and 95% confidence interval (CI) were used as the metric of choice for the evaluation of risk.Results. The literature search generated 427 studies, of which 14 met the inclusion criteria, for a total of 13,927 participants. Our meta-analysis revealed a significant association between rs4986791 and CAD risk in Asians using the dominant model (CT + TT vs CC: OR = 0.35, 95% CI = 0.21-0.56, p < 0.001), heterozygote contrast (CT vs CC: OR = 0.32, 95% CI = 0. 19-0.57, p < 0.001) and allele contrast (T vs C: OR = 0.38, 95% CI = 0.25-0.58, p < 0.001). No significant association between rs4986791 and CAD was observed among Caucasians. For rs4986790, the results provided no evidence of an association with CAD risk.Conclusions. Our analysis suggests that rs4986791 is negatively associated with CAD risk in Asians but not in Caucasians. No association between rs4986790 and CAD risk was found.

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“…Human TLR4 gene encompasses four exons on chromosome 9q32–q33 . TLR4 protein is expressed on cell surface of immune cells, such as lymphocytes, monocytes, macrophages, and polymorphonuclear leucocytes, and tissue cells, such as splenocytes, cardio myocytes, smooth muscle cells, endothelial cells, and airway and gastric epithelial cells .…”

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confidence: 99%

Association of Helicobacter pylori infection with Toll‐like receptor‐4 Thr399Ile polymorphism increased the risk of peptic ulcer development in North of Iran

Tourani

Habibzadeh

Shokri‐Shirvani

et al. 2017

APMIS

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Toll-like receptor-4 (TLR4) polymorphisms may influence host immune response against Helicobacter pylori (H. pylori). This study aimed to investigate whether TLR4 polymorphisms are associated with H. pylori susceptibility and risk of peptic ulcer development or not. The TLR4 + 3725 G/C polymorphism was studied using polymerase chain reaction with confronting two-pair primers (PCR-CTPP). In addition, TLR4 Asp299Gly and Thr399Ile polymorphisms were evaluated by PCR-restriction fragment length polymorphism (RFLP). There was no significant difference in TLR4 + 3725 G/C and Asp299Gly genotype frequencies between non-peptic ulcer (NPUD) and peptic ulcer (PUD) individuals in the context of peptic ulcer development and susceptibility to infection with H. pylori. Nevertheless, a significant association with increased risk for PUD development was observed for polymorphism TLR4 Thr399Ile [odds ratio (OR) = 4.2; 95% confidence interval (CI) = 1.35-13.26; p = 0.01]. Correspondingly, TLR4 Thr399Ile polymorphism was associated with H. pylori susceptibility (OR = 0.27; 95% CI = 0.08-0.88; p = 0.04). In addition, TLR4 Thr399Ile polymorphism increased 4.2-fold, the risk of peptic ulcer development in individuals infected by H. pylori carrying CT + TT genotype. Our results showed that TLR4 Thr399Ile polymorphism along with H. pylori infection may play critical roles in peptic ulcer development in North of Iran.

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Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population

Cited by 7 publications

References 50 publications

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

Association of coronary artery disease with toll-like receptor 4 genetic variants: A meta-analysis

Association of Helicobacter pylori infection with Toll‐like receptor‐4 Thr399Ile polymorphism increased the risk of peptic ulcer development in North of Iran

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