Genetic association of <scp>PLAG</scp>1,<scp>SCD</scp>,<scp>CYP</scp>7B1 and <scp>FASN</scp><scp>SNP</scp>s and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

Kim, Hyun Joo; Sharma, Aditi; Lee, Soo Hyun; Lee, Doo-Ho; Lim, Da Jeong; Cho, Yong Min; Yang, Boh Suk; Lee, Seung Hwan

doi:10.1111/age.12523

Cited by 11 publications

(5 citation statements)

References 6 publications

(4 reference statements)

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“…Smith et al showed that the flavor produced by beef is related to the composition and type of fatty acids, and the high content of unsaturated fatty acids in fat is more conducive to producing a good flavor [ 23 ]. Kim et al found a significant association between the SNPs of SCD and saturated and unsaturated fatty acids in Hanwoo steers [ 24 ]. Taniguchi et al suggested that the SCD gene was responsible for the genetic variation in fatty acid composition in steers of the Japanese Black breed [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the SCD1 Gene and Its Association Analysis with Carcass, Meat Quality, Adipogenic Traits, Fatty Acid Composition, and Milk Production Traits in Cattle

Liu,

Fang,

et al. 2024

Animals

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Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in the biosynthesis of monounsaturated fatty acids and is considered a candidate gene for improving milk and meat quality traits. Sanger sequencing was employed to investigate the genetic polymorphism of the fifth exon and intron of bovine SCD1, revealing four SNPs, g.21272246 A>G, g.21272306 T>C, g.21272422 C>T, and g.21272529 A>G. Further variance analysis and multiple comparisons were conducted to examine the relationship between variation sites and economic traits in Chinese Simmental cattle, as well as milk production traits in Holstein cows. The findings revealed these four loci exhibited significant associations with carcass traits (carcass weight, carcass length, backfat thickness, and waist meat thickness), meat quality (pH value, rib eye area, and marbling score), adipogenic traits (fat score and carcass fat coverage rate), and fatty acid composition (linoleic acid and α-linolenic acid). Furthermore, these loci were additionally found to be significantly associated with average milk yield and milk fat content in cows. In addition, a haplotype analysis of combinations of SNPs showed that H2H3 has a significant association with adipogenic traits and H2H2 was associated with higher levels of linoleic acid and α-linolenic acid than the other combinations. These results suggest that the four SNPs are expected to be prospective genetic markers for the above economic traits. In addition, the function of SNPs in exon 5 of SCD1 on gene expression and protein structure needs to be explored in the future.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of the SCD1 Gene and Its Association Analysis with Carcass, Meat Quality, Adipogenic Traits, Fatty Acid Composition, and Milk Production Traits in Cattle

Liu,

Fang,

et al. 2024

Animals

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“…Those nine genes are located on BTA 4, 14, and 18. The region on BTA 4 has been reported for mastitis resistance ( Rupp and Boichard, 2003 ), growth ( Lu et al, 2013 ), fertility ( Grigoletto et al, 2020b ), and primarly milk ( Ibeagha-Awemu et al, 2016 ; Sanchez et al, 2017 , 2019 ; Van Den Berg et al, 2020 ), while the region on BTA 14 was primarly reported for meat ( Bolormaa et al, 2011 ; Neto et al, 2012 ; Saatchi et al, 2014 ; Sharma et al, 2014 ; Ali et al, 2015 ; Song et al, 2016 ; Kim et al, 2017 ; Akanno et al, 2018 ; Grigoletto et al, 2020a ; Srikanth et al, 2020 ; Wang et al, 2020 ; Rezende et al, 2021 ), production ( Snelling et al, 2010 ; Lu et al, 2013 ; Martínez et al, 2014 ; Saatchi et al, 2014 ; Akanno et al, 2018 ; Zhong et al, 2019 ; Zhang et al, 2020 ), and exterior traits ( Pryce et al, 2011 ; Pausch et al, 2016 ; Wu et al, 2016 ; Marete A. G. et al, 2018 ; Bouwman et al, 2018 ; Tribout et al, 2020 ). Within this region, for example, we find the gene XKR4 associated with subcutaneous rump fat thickness and growth ( Neto et al, 2012 ; Magalhã et al, 2016 ; An et al, 2019 ; Smith et al, 2019 ) .…”

Section: Discussionmentioning

confidence: 99%

Genomic diversity and relationship analyses of endangered German Black Pied cattle (DSN) to 68 other taurine breeds based on whole-genome sequencing

et al. 2023

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German Black Pied cattle (Deutsches Schwarzbuntes Niederungsrind, DSN) are an endangered dual-purpose cattle breed originating from the North Sea region. The population comprises about 2,500 cattle and is considered one of the ancestral populations of the modern Holstein breed. The current study aimed at defining the breeds closest related to DSN cattle, characterizing their genomic diversity and inbreeding. In addition, the detection of selection signatures between DSN and Holstein was a goal. Relationship analyses using fixation index (FST), phylogenetic, and admixture analyses were performed between DSN and 68 other breeds from the 1000 Bull Genomes Project. Nucleotide diversity, observed heterozygosity, and expected heterozygosity were calculated as metrics for genomic diversity. Inbreeding was measured as excess of homozygosity (FHom) and genomic inbreeding (FRoH) through runs of homozygosity (RoHs). Region-wide FST and cross-population-extended haplotype homozygosity (XP-EHH) between DSN and Holstein were used to detect selection signatures between the two breeds, and RoH islands were used to detect selection signatures within DSN and Holstein. DSN showed a close genetic relationship with breeds from the Netherlands, Belgium, Northern Germany, and Scandinavia, such as Dutch Friesian Red, Dutch Improved Red, Belgian Red White Campine, Red White Dual Purpose, Modern Angler, Modern Danish Red, and Holstein. The nucleotide diversity in DSN (0.151%) was higher than in Holstein (0.147%) and other breeds, e.g., Norwegian Red (0.149%), Red White Dual Purpose (0.149%), Swedish Red (0.149%), Hereford (0.145%), Angus (0.143%), and Jersey (0.136%). The FHom and FRoH values in DSN were among the lowest. Regions with high FST between DSN and Holstein, significant XP-EHH regions, and RoH islands detected in both breeds harbor candidate genes that were previously reported for milk, meat, fertility, production, and health traits, including one QTL detected in DSN for endoparasite infection resistance. The selection signatures between DSN and Holstein provide evidence of regions responsible for the dual-purpose properties of DSN and the milk type of Holstein. Despite the small population size, DSN has a high level of diversity and low inbreeding. FST supports its relatedness to breeds from the same geographic origin and provides information on potential gene pools that could be used to maintain diversity in DSN.

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“…The bovine SCD gene is mapped on chromosome 26 with six exons, and plays an essential role in regulating the expression of genes that are involved in lipogenesis as well as regulating mitochondrial fatty acid oxidation and body energy homeostasis. Candidate gene studies in Hanwoo cattle have reported that polymorphisms in the SCD gene have important effects on marbling score, meat texture, and grade of meat quality [ 41 , 58 , 59 , 60 , 61 , 62 ]. The STAT6 (signal transducer and activator of transcription 6) gene, located on chromosome 5 and identified to be linked to back fat thickness, was previously shown to be associated with carcass weight, calculated yield grade, cutability, back fat rate, dry matter intake, days on feed, and average daily gain in different beef cattle breeds [ 63 ].…”

Section: Candidate Genes Affecting Back Fat Thickness and Marbling Scorementioning

confidence: 99%

Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle

Naserkheil

Manzari

Dang

et al. 2022

CIMB

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The purpose of the current review was to explore and summarize different studies concerning the detection and characterization of candidate genes and genomic regions associated with economically important traits in Hanwoo beef cattle. Hanwoo cattle, the indigenous premium beef cattle of Korea, were introduced for their marbled fat, tenderness, characteristic flavor, and juiciness. To date, there has been a strong emphasis on the genetic improvement of meat quality and yields, such as backfat thickness (BFT), marbling score (MS), carcass weight (CW), eye muscle area (EMA), and yearling weight (YW), as major selection criteria in Hanwoo breeding programs. Hence, an understanding of the genetics controlling these traits along with precise knowledge of the biological mechanisms underlying the traits would increase the ability of the industry to improve cattle to better meet consumer demands. With the development of high-throughput genotyping, genomewide association studies (GWAS) have allowed the detection of chromosomal regions and candidate genes linked to phenotypes of interest. This is an effective and useful tool for accelerating the efficiency of animal breeding and selection. The GWAS results obtained from the literature review showed that most positional genes associated with carcass and growth traits in Hanwoo are located on chromosomes 6 and 14, among which LCORL, NCAPG, PPARGC1A, ABCG2, FAM110B, FABP4, DGAT1, PLAG1, and TOX are well known. In conclusion, this review study attempted to provide comprehensive information on the identified candidate genes associated with the studied traits and genes enriched in the functional terms and pathways that could serve as a valuable resource for future research in Hanwoo breeding programs.

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Genetic association of PLAG1,SCD,CYP7B1 and FASNSNPs and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

Cited by 11 publications

References 6 publications

Polymorphisms of the SCD1 Gene and Its Association Analysis with Carcass, Meat Quality, Adipogenic Traits, Fatty Acid Composition, and Milk Production Traits in Cattle

Polymorphisms of the SCD1 Gene and Its Association Analysis with Carcass, Meat Quality, Adipogenic Traits, Fatty Acid Composition, and Milk Production Traits in Cattle

Genomic diversity and relationship analyses of endangered German Black Pied cattle (DSN) to 68 other taurine breeds based on whole-genome sequencing

Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle

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