Genetic association of CTLA4 gene with polycystic ovary syndrome in the Chinese Han population

Su, Jing; Li, Yan; Su, Guanglong; Wang, Jing; Qiu, Ting; Ma, Rong; Zhao, Lei

doi:10.1097/md.0000000000011422

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…The polymorphism of CTLA-4-+49 was genotyped widely in many autoimmune diseases such as RA (20,34) Behçet's Disease (1), pathogenesis of Graves' disease (19), Oral Lichen Planus disease (6), and systemic lupus erythematosus and its geographical distribution (17). The polymorphism of CTLA-4 and CT60 was also genotyped widely in a lot of autoimmune diseases suach as; RA (28,33), Thalassemia (29), Sjögren Syndrome (7), Polymorphism in Renal Cell Cancer (5), Production of Thyroid Autoantibody (40) , Polycystic ovarian syndrome (13,15)…”

Section: Resultsmentioning

confidence: 99%

Association Between Polymorphism in Cytotoxic T Lymphocyte Antigen -4 Gene and the Risk of Rheumatoid Arithritis in Iraqi Patients

Rawaa¹

2022

Iraqi J. Agric. Sci.

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CTLA4 is well known that it is expressed in activated T-lymphocyte, and can be distinguished in cancer phenomena as well as many chronic diseases. This study was designed aiming to find a correlation between CTLA-4 and Rheumatoid Arthritis (RA). This research was carried out at Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. In this study, 245 patients diagnosed with rheumatoid arthritis and 188 healthy volunteers' individuals (control group) were selected randomly. The diagnosis of the RA to both patients group and healthy individuals were characterized according to a certain protocols. The sequence of four (JO31, CT60, +49, and MH30 genotypes) were carried out using PCR-DGGE. The polymorphisms (SNPs) were genotyped for the control and the patients and the distribution of the genotypes was carried out according to HWE (P<0.05) for the two groups. The effect of two alleles on the susceptibility of RA, were investigated thoroughly, and there was a major association between the CT60, +49 alleles with the risk of RA (OR 1.43, 95%Cl (1.14-1.89), and the P-value 0.004 for CT60), while for +49 it was (OR 1.38, 95%Cl (1.04-1.77) and the P-value 0.009). There is a significant correlation between CTLA-4 genes and Rheumatoid Arthritis (RA) and both CT60 and +49 can be the main reason for RA, while JO31 and MH30 are not associated with CTLA-4.

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Section: Resultsmentioning

confidence: 99%

Association Between Polymorphism in Cytotoxic T Lymphocyte Antigen -4 Gene and the Risk of Rheumatoid Arithritis in Iraqi Patients

Rawaa¹

2022

Iraqi J. Agric. Sci.

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“…Investigation of rs733618 and rs16840252 in T cell activation would uncover the underlying mechanism in development of GO. In Table 6, disease association of rs733618 [23,27,28,29,30,31,32,33,34] and rs16840252 [35,36] were summarized.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Correlation between Graves’ Ophthalmopathy and CTLA4 Gene Polymorphism

Chen

Chu

Wen

et al. 2019

JCM

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Graves’ disease (GD) is an autoimmune inflammatory disease, and Graves’ ophthalmopathy (GO) occurs in 25–50% of patients with GD. Several susceptible genes were identified to be associated with GO in some genetic analysis studies, including the immune regulatory gene CTLA4. We aimed to find out the correlation of CTLA4 gene polymorphism and GO. A total of 42 participants were enrolled in this study, consisting of 22 patients with GO and 20 healthy controls. Chi-square or Fisher’s exact test were used to appraise the association between Graves’ ophthalmopathy and CTLA4 single nucleotide polymorphisms (SNPs). All regions of CTLA4 including promoter, exon and 3’UTR were investigated. There was no nucleotide substitution in exon 2 and exon 3 of CTLA4 region, and the allele frequencies of CTLA4 polymorphisms had no significant difference between patients with GO and controls. However, the genotype frequency of “TT” genotype in rs733618 significantly differed between patients with GO and healthy controls (OR = 0.421, 95%CI: 0.290–0.611, p = 0.043), and the “CC” and “CT” genotype in rs16840252 were nearly significantly differed in genotype frequency (p = 0.052). Haplotype analysis showed that CTLA4 Crs733618Crs16840252 might increase the risk of GO (OR = 2.375, 95%CI: 1.636–3.448, p = 0.043). In conclusion, CTLA4 Crs733618Crs16840252 was found to be a potential marker for GO, and these haplotypes would be ethnicity-specific. Clinical application of CTLA4 Crs733618Crs16840252 in predicting GO in GD patients may be beneficial.

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“…Considerable evidence suggests that PCOS has diverse causes, arising as a complex trait with contributions from both heritable and environmental factors that affect ovarian steroidogenesis [15] . Insulin resistant leading to hyperinsulinuma, in part related to coexistent obesity, is the most common non-steroidogenic factor in polycystic ovaries, where this complex interaction generally mimics an autosomal dominant trait [16] .…”

Section: Table (3): Genotypes and Alleles Frequencies Of Rs733618 Pol...mentioning

confidence: 99%

Studying Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

Shaheed,

Abbass,

Jasim

2019

AJPS

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Polycystic ovarian syndrome (PCOS) considers as the most common disorder among women during reproductive age. Its common features involve hyperandrogenism, chronic anovulation, and weight gain. Till now, the pathogenesis of PCOS stay unknown, and there is evidence considered PCOS as a low-grade inflammatory disease. Polycystic ovarian syndrome is associated with a variety of endocrine and metabolic disturbances. The present study was designed to detect the role of (CTLA-4) gene polymorphism (rs733618) with PCOS. A total of 60 PCOS patients and 30 healthy women, matching in average age and body mass index (BMI), were enrolled in this study. Patients with PCOS were attend to AL - Nahrain University High Institute for Infertility Assisted Reproductive Technology, in Baghdad between Septembers to December/2018. Blood samples were aspirated from both groups to detection (CTLA-4) gene polymorphism (rs733618) by tetra-primer amplification-refractory mutation system based on real time polymerase chain reaction (ARMS-qPCR). The obtained results revealed normal genotyping for both groups. The result of current study confirms that there is no role of (CTLA-4) gene polymorphism (rs 733618) in PCOS.

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Genetic association of CTLA4 gene with polycystic ovary syndrome in the Chinese Han population

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 22 publications

Association Between Polymorphism in Cytotoxic T Lymphocyte Antigen -4 Gene and the Risk of Rheumatoid Arithritis in Iraqi Patients

Association Between Polymorphism in Cytotoxic T Lymphocyte Antigen -4 Gene and the Risk of Rheumatoid Arithritis in Iraqi Patients

Investigation of the Correlation between Graves’ Ophthalmopathy and CTLA4 Gene Polymorphism

Studying Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

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