Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko; S, Ban; Miyashita, Chihiro; Okada, Emiko; Limpar, Mariko; Yoshioka, Eiji; Kajiwara, Jumboku; Todaka, Takashi; Saijo, Yasuaki; Kishi, Reiko

doi:10.1016/j.toxlet.2013.03.013

Cited by 26 publications

(12 citation statements)

References 61 publications

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“…In our study, we found that the maternal genetic polymorphisms in AHR or CYP1A1 independently modified dioxin concentrations in maternal blood, suggesting different dioxin accumulation in the body of individuals with these genotypes, which would lead to different dioxin exposure levels [55]. CYP1A1 activation mediated by AHR Environ Health Prev Med (2013) 18:429-450 443 is an important mechanism for metabolizing dioxins.…”

Section: Genetic Susceptibility To the Exposuresmentioning

confidence: 65%

“…No significant differences were found among blood dioxin concentrations and polymorphisms in AHRR, CYP1A1 (rs1048963), CYP1A2 and CYP1B1. Thus, polymorphisms in AHR and CYP1A1 (rs4646903) were associated with maternal dioxin concentrations [55].…”

Section: Gene-environment Interactionmentioning

confidence: 99%

“…, rs1801133 (C677T) and rs1801131 (A1298C) of MTHFR (methylenetetrahydrofolate reductase). In addition, copy number variations (CNVs) in GSTM1 (glutathione S-transferase mu-1) and GSTT1 (glutathione S-transferase theta-1) were also evaluated [55][56][57][58].…”

Section: Genetic Analysesmentioning

confidence: 99%

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Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Kishi

Kobayashi

Ikeno

et al. 2013

Environ Health Prev Med

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125

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The Hokkaido Study on Environment and Children's Health is an ongoing cohort study that began in 2002. The study consists of two prospective birth cohorts, the Sapporo cohort (n = 514) and the Hokkaido large-scale cohort (n = 20,940). The primary goals of this study are to first examine the potential negative effects of perinatal environmental chemical exposures on birth outcomes, including congenital malformations and growth retardation; second, to evaluate the development of allergies, infectious diseases and neurodevelopmental disorders and perform longitudinal observations of the children's physical development to clarify the causal relationship between these outcomes and environmental chemicals; third, to identify individuals genetically susceptible to environmental chemicals; finally, to identify the additive effects of various environmental factors in our daily life, such as secondhand smoke exposure or low folate intake during early pregnancy. In this paper, we introduce our recent progress in the Hokkaido study with a cohort profile updated in 2013. For the last ten years, we followed pregnant women and their offspring, measuring various environmental chemicals, i.e., PCB, OH-PCB and dioxins, PFCs (Perfluorinated Compounds), Organochlorine pesticides, Phthalates, bisphenol A and mercury. We discovered that the concentration of toxic equivalents (TEQ) of dioxin and other specific congeners of PCDF or PCDD have effects on birth weight, infants' neurodevelopment and immune function. There were significant gender differences in these effects; our results suggest that male infants have more susceptibility to those chemical exposures than female infants. Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels. These genetic susceptibility factors influenced the body size of children born from mothers that either smoked or were passively exposed to tobacco smoke. Further studies investigating the correlation between epigenetics, the effects of intrauterine exposure to environmental chemicals and developmental factors related to health and disease are warranted.

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Section: Genetic Susceptibility To the Exposuresmentioning

confidence: 65%

Section: Gene-environment Interactionmentioning

confidence: 99%

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Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Kishi

Kobayashi

Ikeno

et al. 2013

Environ Health Prev Med

Self Cite

125

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“…The associations between maternal exposure to dioxins during pregnancy and maternal genetic polymorphisms were also examined in the Sapporo cohort. Maternal polymorphisms in the AhR (G>A, Arg554Lys) and CYP1A1 (T>C, MspI) genes were associated with maternal dioxin concentration [ 60 ]. Moreover, among 29 dioxin congeners, reduced infant birth weight was associated with increased levels of certain dioxin congeners [ 59 ] (Fig.…”

Section: Resultsmentioning

confidence: 99%

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Kishi

Araki

Minatoya

et al. 2017

Environ Health Prev Med

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The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose of this report is to update the progress of the Hokkaido Study, to summarize the recent results, and to suggest future directions. In particular, this report provides the basic characteristics of the cohort populations, discusses the population remaining in the cohorts and those who were lost to follow-up at birth, and introduces the newly added follow-up studies and case-cohort study design. In the Sapporo cohort of 514 enrolled pregnant women, various specimens, including maternal and cord blood, maternal hair, and breast milk, were collected for the assessment of exposures to dioxins, polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances, phthalates, bisphenol A, and methylmercury. As follow-ups, face-to-face neurobehavioral developmental tests were conducted at several different ages. In the Hokkaido cohort of 20,926 enrolled pregnant women, the prevalence of complicated pregnancies and birth outcomes, such as miscarriage, stillbirth, low birth weight, preterm birth, and small for gestational age were examined. The levels of exposure to environmental chemicals were relatively low in these study populations compared to those reported previously. We also studied environmental chemical exposure in association with health outcomes, including birth size, neonatal hormone levels, neurobehavioral development, asthma, allergies, and infectious diseases. In addition, genetic and epigenetic analyses were conducted. The results of this study demonstrate the effects of environmental chemical exposures on genetically susceptible populations and on DNA methylation. Further study and continuous follow-up are necessary to elucidate the combined effects of chemical exposure on health outcomes.

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“…The validated TaqMan probes were prepared and each of the reporters was quenched by excess MGB. PCR was performed and the fluorescence of the products was measured using a 7300/7500 Real-Time PCR system (Applied Biosystems) (26,27). This resulted in the clear identification of the CC, CA, and AA genotypes of CYP1A2.…”

Section: Genotyping Analysesmentioning

confidence: 99%

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

et al. 2017

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Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

Cited by 26 publications

References 61 publications

Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study

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