Genetic association of AKAP10 gene polymorphism with reduced risk of preterm birth

Langmia, Immaculate Mbongo; Apalasamy, Yamunah Devi; Suki, Siti Zaleha; Omar, Siti Zawiah; Mohamed, Zahurin

doi:10.1038/jp.2015.68

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…38,39 In addition, the majority of the literature contains candidate gene studies that showed 25 additional preterm birth-associated loci that did not reach genome-wide significance level, including AKAP10, ATG16L1, DNMT3B, FLT1, FNDC5, FSHR, IL10, IL16, IL1B, IL1R2, IL4, LEPR, LIFR-AS1, MMP1, MMP2, OGG1, PER3, PGR, PLA2G4D, PRKCA, RLN2, SKA2, TIMP2, TLR4, and VDR. [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] Of these, rs1800872 in IL10 has notably been associated with various preterm birth outcomes in multiple studies with different sample populations: specifically, with preterm labor associated with preterm premature rupture of membranes at 26 to 34 weeks of gestation in Zaporizhzhia women, with preterm birth at 24 to 37 weeks in Korean women, and with preterm birth before 37 weeks in Indian women. 43,54,56 Medical History ►Fig.…”

Section: Geneticsmentioning

confidence: 99%

A Scoping Review of Preterm Birth Risk Factors

Tang,

Mallia,

Yan

et al. 2023

Am J Perinatol

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Preterm birth is a major cause of neonatal morbidity and mortality, but its etiology and risk factors are poorly understood. We undertook a scoping review to illustrate the breadth of risk factors for preterm birth that have been reported in the literature. We conducted a search in the PubMed database for articles published in the previous 5 years. We determined eligibility for this scoping review by screening titles and abstracts, followed by full-text review. We extracted odds ratios and other measures of association for each identified risk factor in the articles. A total of 2,509 unique articles were identified from the search, of which 314 were eligible for inclusion in our final analyses. We summarized risk factors and their relative impacts in the following categories: Activity, Psychological, Medical History, Toxicology, Genetics, and Vaginal Microbiome. Many risk factors for preterm birth have been reported. It is challenging to synthesize findings given the multitude of isolated risk factors that have been studied, inconsistent definitions of risk factors and outcomes, and use of different covariates in analyses. Novel methods of analyzing large datasets may promote a more comprehensive understanding of the etiology of preterm birth and ability to predict the outcome. Key Points

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Section: Geneticsmentioning

confidence: 99%

A Scoping Review of Preterm Birth Risk Factors

Tang,

Mallia,

Yan

et al. 2023

Am J Perinatol

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“…For example, investigators have studied genes that may be associated with uterine quiescence, including SNPs in the A kinase anchor protein (PRKA) gene, known to impact muscle contraction and myometrial quiescence, and found an association between two polymorphisms (rs119672 and rs169412) and term delivery. 53 Other studies have also investigated polymorphisms in the human relaxin gene (RLN); SNPS in this gene have been associated with PPROM, and others have theorized that it may also impact uterine quiescence. 54 In a small nested case-control study performed by the Danish National Birth Registry, maternal RLN2 genotype was associated with PTB and PPROM.…”

Section: Identification Of "Prematurity Gene(s)"-the Candidate Gene Amentioning

confidence: 99%

Genomics of Preterm Birth—Evidence of Association and Evolving Investigations

McPherson

Manuck

2016

Amer J Perinatol

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Preterm birth (PTB) is a large public health problem in the United States and worldwide. There is a clear genetic component to the pathogenesis of PTB, as evidenced by twin studies, heritability studies, and investigations from large population databases. Although numerous single nucleotide polymorphisms have been associated with PTB, results have been inconsistent and overall disappointing. With recent advances in genetic technology, investigations are moving beyond simple, more traditional candidate gene studies, and have expanded to encompass more exploratory analyses using high-throughput genetic techniques. Care should be taken to consider the potential impact of fetal genotype, the environment, and gene-drug interactions (pharmacogenomics) in addition to maternal genotype. Future research should capitalize on evolving analytic techniques, including pathway analyses and correlation of genetic and functional data to optimize discovery, increase knowledge regarding prematurity pathogenesis, and begin to develop novel therapeutic strategies.

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Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth

Langmia

Apalasamy²,

Omar³

et al. 2016

Pharmacogenetics and Genomics

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This study indicates a significant association between IL1B levels and reduced risk of PTB among the Malaysian Malay women. This study shows the impact of IL1B levels on susceptibility to PTB disease; however, the high levels of IL1B observed among women in the preterm group are not associated with IL1B SNPs investigated in this study; IL1B high levels may be because of other factors not explored in this study and therefore warrant further investigation.

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Genetic association of AKAP10 gene polymorphism with reduced risk of preterm birth

Cited by 3 publications

References 20 publications

A Scoping Review of Preterm Birth Risk Factors

A Scoping Review of Preterm Birth Risk Factors

Genomics of Preterm Birth—Evidence of Association and Evolving Investigations

Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth

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