Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population

Ramya, K; Ayyappa, Kuppuswamy Ashok; Ghosh, Saurabh; Mohan, Viswanathan; Radha, Venkatesan

doi:10.1016/j.gene.2013.09.012

Cited by 110 publications

(125 citation statements)

References 38 publications

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“…In line with this, the same variant was nominally associated with circulating adiponectin in the Sorbs (P value = 0.027). Consistently with other studies, we observed three other markers influencing adiponectin serum levels (Ramya et al 2013). Data are presented as mean ± SD.…”

Section: Discussionsupporting

confidence: 92%

“…In line with others describing significant differences between male and female adiponectin serum levels (Heid 2006) which is most likely caused by enriched testosterone levels in men inhibiting the secretion of high molecular weight (HMW) adiponectin from adipocytes (Xu et al 2005;Wang et al 2008), we found *19 % higher serum levels in women compared to men. Many studies described genetic variants in the ADIPOQ locus to be associated with reduced adiponectin levels in T2D, obesity and impaired insulin sensitivity (Vasseur 2002;Comuzzie et al 2001;Ramya et al 2013;Peters et al 2013;Kadowaki 2006). Consistently, in the Sorbs, adiponectin serum levels are negatively correlated with BMI.…”

Section: Discussionmentioning

confidence: 89%

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Role of genetic variants in ADIPOQ in human eating behavior

et al. 2014

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The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eating. Here, we tested the hypothesis that (1) adiponectin serum levels correlate with human eating behavior factors and (2) that genetic variants of the ADIPOQ locus influence both serum levels and eating behavior. We analyzed 11 SNPs within ADIPOQ and in the 5 0 UTR and measured serum adiponectin levels in 1,036 individuals from the German Sorbs population. The German version of the three-factor eating questionnaire (FEV) was completed by 548 Sorbs. For replication purposes, we included an independent replication cohort from Germany (N = 350). In the Sorbs, we observed positive correlations of restraint with adiponectin serum levels (P = 0.001; r = 0.148) which, however, did not withstand adjustment for covariates (P = 0.083; r = 0.077). In addition, four SNPs were nominally associated with serum adiponectin levels (all P \ 0.05). Of these, two variants (rs3774261; rs1501229, all P \ 0.05) were also related to disinhibition. Furthermore, three variants were exclusively associated with hunger (rs2036373, P = 0.049) and disinhibition (rs822396; rs864265, all P \ 0.05). However, none of these associations withstood Bonferroni corrections for multiple testing (all P [ 9.3 9 10 -4 ). In our replication cohort, we observed similar effect directions at rs1501229 for disinhibition and hunger. A meta-analysis resulted in nominal statistical significance P = 0.036 (Z score 2.086) and P = 0.017 (Z score 2.366), respectively. Given the observed relationship of the SNPs with adiponectin levels and eating behavior, our data support a potential role of adiponectin in human eating behavior. Whether the relationship with eating behavior is mediated by the effects of circulating adiponectin warrants further investigations.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Role of genetic variants in ADIPOQ in human eating behavior

et al. 2014

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“…Our findings are similar those reported by Filippi et al [32]. Gui et al [10] and recent study of Ramya et al [33]. revealed that the TT genotype of +276 G/T variant was observed to be significantly associated with hypoadiponectinemia.…”

Section: Discussionsupporting

confidence: 93%

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Abd-Elbaky¹,

Matty²

2016

J Diabetes Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and increased levels of circulating cytokines. Adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (Il-6), are important cytokines mediators in the pathogenesis of T2DM. The single nucleotide polymorphisms (SNPs) present in the regulatory regions of cytokine genes often have an impact on their expression levels.Aim: Explore potential associations between SNP+276 G/T of adiponectin, SNP -308 G/A of TNF-α and SNP -174 C/G of IL-6 genes with T2DM and to assess its influence on their serum levels. Subjects and Methods:From the Egyptian population, we enrolled 95 T2DM patients and 85 non-diabetic controls. Serum adiponectin, TNF-α and IL-6 were measured. Genotyping for three SNPs of the adiponectin, TNF-α and IL-6 genes was performed by polymerase chain reaction-restriction fragment length polymorphism.Results: Subjects with the GT/TT genotype of SNP 276 were at increased risk for T2DM (OR=15.88, CI=7.56-33.31, P ≤ 0.01) and associated with hypoadiponectinemia compared with the GG genotype. Furthermore, the allelic frequency of the A allele of SNP 308 was significantly different between T2DM patients compared to controls (X 2 =30.54, P ≤ 0.0001). Moreover, Individuals with T2DM carrying the GA/AA genotypes had significantly higher serum TNF-α levels than those carrying GG genotype. In addition, Carriers of G allele of IL-6 were significantly more likely associated with T2DM.

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“…Consistent with previous cross-sectional studies (27,28,29), the C276GOT variant showed a significant association with DM in our cohort. The current study demonstrated that the C276GOT variant was independently associated with incident CHD in men, even after adjustment for DM or its related traits, together with other potential confounding factors, in the different multiple adjustment models.…”

Section: Discussionsupporting

confidence: 93%

Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study

Cheung

Hui

Cheung

et al. 2014

European Journal of Endocrinology

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Objective: Circulating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the primary role of adiponectin, our major objective was to investigate the relationship between single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and incident CHD in a population-based cohort with no CHD at baseline. Design and methods: We conducted a 16-year longitudinal study in 2196 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). During 33 862 person-years of follow-up, 184 subjects developed CHD (cumulative incidence rateZ5.4 per 1000 person-years). Nine ADIPOQ SNPs with potential functional relevance or shown to be associated with adiponectin levels and/or CHD were genotyped. Results: Among the nine ADIPOQ SNPs, C276GOT (rs1501299) was independently associated with incident CHD in men but not in women, even after adjustments for traditional cardiovascular risk factors (P adjusted Z5.5!10 K3 to 0.023; hazard ratioZ1.39-1.54). Furthermore, there was a significant association of the T allele of C276GOT with a lower adiponectin level (PZ0.027; b (95% CI)ZK0.05 (K0.10, K0.01). Conclusions: This study demonstrated that C276GOT may be an independent predictor of CHD development. Our findings suggest that low adiponectin levels, as may be influenced by C276GOT, confer a higher risk of CHD, in keeping with a role of hypoadiponectinaemia in the development of CHD in the general population.

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Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population

Cited by 110 publications

References 38 publications

Role of genetic variants in ADIPOQ in human eating behavior

Role of genetic variants in ADIPOQ in human eating behavior

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study

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