Genetic association between mannose-binding lectin polymorphisms and viral hepatitis: a meta-analysis

Abstract

Some previous genetic association studies have tried to investigate potential associations between mannose-binding lectin (MBL) polymorphisms and viral hepatitis. However, the results of those studies were not consistent. Therefore, we performed the current meta-analysis to explore associations between MBL polymorphisms and viral hepatitis in a large pooled population. A systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible studies for pooled analyses. We used Review Manager version 5.3.3 to conduct statistical analyses. In total, 27 studies were included for analysis (4840 cases and 5729 controls). The pooled analyses showed that MBL promoter (-211C/G, dominant model: P = 0.0002, I2 = 40%; over-dominant model: P = 0.0001, I2 = 22%) and exon 1 (codon 52, 54 and 57, dominant model: P = 0.04, I2 = 49%; allele model: P = 0.01, I2 = 48%) polymorphisms were both significantly associated with viral hepatitis in the overall population. Further subgroup analyses revealed similarly significant findings for MBL promoter polymorphism in HBV and HCV, but no positive results were detected in subgroup analyses for MBL exon 1 polymorphism. These results suggested that MBL promoter and exon 1 polymorphisms could be used to identify individuals at higher susceptibility to HBV and HCV.

Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity

“…The results of studies on the potential association between MBL polymorphisms and CHB have been inconsistent. A meta-analysis showed that polymorphisms in the MBL promoter and exon 1 are significantly associated with HBV infection, and Allele D is associated with HBV persistence ( Qie et al., 2019 ). Ficolin-2 levels are positively correlated with the degree of liver inflammation in patients with CHB.…”