Genetic association between HOTAIR gene and the risk of cancer: an updated meta-analysis

Moazeni‐Roodi, Abdolkarim; Aftabi, Sajjad; Sarabandi, Sahel; Karami, Shima; Hashemi, Mohammad; Ghavami, Saeid

doi:10.1007/s12041-020-01214-w

Cited by 11 publications

(11 citation statements)

References 63 publications

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“…For instance, rs4759314 has been previously linked with HOTAIR overexpression in pancreatic cancer[ 31 ]. In line with Moazeni-Roodi et al [ 25 ] observations, another recent meta-analysis including more than 100 000 subjects, showed that rs4759314 HOTAIR may serve as a genetic cancer biomarker. More specifically, stratified analysis revealed that GG carriers of the HOTAIR rs4759314 had a significantly increased risk for pancreatic cancer than AA genotype.…”

Section: Discussionsupporting

confidence: 74%

“…Previous studies have demonstrated that HOTAIR rs4759314 polymorphism plays an important role in the pathogenesis and progression of multiple diseases, including cancer[ 28 - 30 ]. Indeed, the results of a recent meta-analysis revealed that rs4759314 is included in the most common HOTAIR polymorphisms associated with cancer risk[ 25 ]. For instance, rs4759314 has been previously linked with HOTAIR overexpression in pancreatic cancer[ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a meta-analysis conducted by Min et al [ 24 ] in 2018 has associated HOTAIR polymorphisms with cancer development. Similarly, two updated recent meta-analyses concluded that several polymorphisms are indeed associated with cancer risk[ 25 , 26 ]. However, to the best of our knowledge HOTAIR polymorphisms and CCA risk have not been instigated, so far.…”

Section: Introductionmentioning

confidence: 99%

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Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

Lampropoulou¹,

Laschos²,

Aravantinos³

et al. 2021

WJCC

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BACKGROUND Cholangiocarcinoma (CCA) represents a rare but highly aggressive malignancy that is often challenging to diagnose, especially in early stages. The role of existing tumor biomarkers for CCA diagnosis, remains controversial due to their low sensitivity and specificity. Increasing evidence has implicated long non-coding ribonucleic acid polymorphisms with cancer susceptibility in a variety of tumor types. The association between long non-coding ribonucleic acid homeobox protein transcript antisense intergenic ribonucleic acid (HOTAIR) polymorphisms and CCA risk has not been reported yet. AIM To investigate the influence of HOTAIR variants on the risk of CCA development. METHODS We conducted a case-control study in which three HOTAIR single nucleotide polymorphisms (rs920778, rs4759314 and rs7958904) were genotyped in a Greek cohort. Our study population included 122 CCA patients (80 males and 42 females) and 165 healthy controls. The polymorphisms under investigation were examined in peripheral blood samples. RESULTS HOTAIR rs4759314 AG and GG genotypes were associated with a significantly increased CCA risk [ P = 0.004, odds ratio: 3.13; 95% confidence interval: 1.65-5.91 and P = 0.005, odds ratio: 12.31; 95% confidence interval: 1.48-101.87, respectively]. However, no significant associations of HOTAIR rs920778, and rs7958904 were detected. Similarly, we found no significant associations between rs4759314 AA genotype and CCA susceptibility. CONCLUSION HOTAIR rs4759314 AG and GG genotypes may be implicated with CCA development and may serve as a potential diagnostic biomarker.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

Lampropoulou¹,

Laschos²,

Aravantinos³

et al. 2021

WJCC

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“…Cancer constitutes one of the most important global health concerns (1). The precise mechanisms of carcinogenesis remain largely elusive, but both genomic and environmental factors have been recognized to contribute to cancer development (2)(3)(4)(5)(6)(7). Over the years, it has become evident that certain specific single nucleotide polymorphisms (SNPs) are related to cancer predisposition (6, [8][9][10][11].…”

Section: Contextmentioning

confidence: 99%

Association between Long Non-coding RNA POLR2E rs3787016 Polymorphism and Cancer Susceptibility: A Meta-analysis of 8725 Cancer Cases and 10710 Controls

2020

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Objectives: Several studies have reported a correlation between the POLR2E rs3787016 polymorphism and cancer development, but findings are inconsistent. Therefore, we designed the current study to understand how rs3787016 polymorphism impacts cancer susceptibility. Methods: We searched the Scopus, Web of Science, and PubMed databases for studies related to the topic of interest published up to March 2019. A total of 11 relevant studies, encompassing 8,761 cancer cases and 10,534 controls, were retrieved and subject to quantitative analysis. The strength of the relationship was evaluated using the pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: Overall, the findings proposed a positive association between rs189037 polymorphism and susceptibility to cancer in homozygous (OR = 1.32, 95% CI = 1.11 - 1.57, P = 0.002, TT vs. CC), recessive (OR = 1.21, 95% CI = 1.06-1.39, P = 0.005, TT vs. CT + CC), and allele (OR = 1.12, 95% CI = 1.02-1.22, P = 0.021, T vs. C) genetic models. Stratified analysis showed that rs3787016 increased the risk of prostate and breast cancer. In addition, we found a significant association between the variant and increased cancer risk in Asian and Caucasian populations. Conclusions: In summary, the findings of the current meta-analysis suggest that the POLR2E rs3787016 polymorphism is an indicator of cancer susceptibility.

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“…Cancer poses a major health problem in both developing and developed countries [ 1–3 ]. There were approximately 18.1 million new cases and 9.6 million cancer deaths in 2018 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer

et al. 2020

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Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development. This meta-analysis aimed to estimate the association between FGFR4 rs351855 (Gly388Arg), rs1966265 (Val10Ile), rs7708357, rs2011077, and rs376618 polymorphisms and cancer risk. Eligible studies were identified from electronic databases. All statistical analyses were achieved with the STATA 14.0 software. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) used to quantitatively estimate the association. Overall, no significant association was found between rs351855, rs2011077, and rs376618 polymorphism with the risk of overall cancer. The rs1966265 polymorphism significantly decreased the risk of cancer in recessive (OR=0.87, 95%CI=0.78-0.97, p=0.009, TT vs CT+CC) genetic model. Whereas the rs7708357 polymorphism was positively associated with cancer risk in dominant (OR=1.17, 95%CI=1.02-1.36, p=0.028) genetic model. Stratified analysis revealed that rs351855 variant significantly increased the risk of prostate cancer in heterozygous (OR=1.16, 95%CI=1.02-1.32, p=0.025 AG vs GG), dominant (OR=1.20, 95%CI=1.06-1.35, p=0.004, AG+AA vs GG), and allele (OR=1.22, 95%CI=1.06-1.41, p=0.005, A vs G) genetic models. In summary, the findings of this meta-analysis indicate that rs1966265, rs7708357 and rs351855 polymorphisms are correlated to cancer development. Further well-designed studies are necessary to draw more precise conclusions.

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Genetic association between HOTAIR gene and the risk of cancer: an updated meta-analysis

Cited by 11 publications

References 63 publications

Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

Association between Long Non-coding RNA POLR2E rs3787016 Polymorphism and Cancer Susceptibility: A Meta-analysis of 8725 Cancer Cases and 10710 Controls

An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer

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