Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes

Sun, Jialin; Li, Mujia; Sun, Huaqin; Lin, Ziyuan; Shi, Bing; Jia, Zhonglin

doi:10.1038/s10038-024-01222-z

J Hum Genet

2024

DOI: 10.1038/s10038-024-01222-z

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Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes

Jialin Sun,

Mujia Li,

Huaqin Sun

et al.

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2024

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Testing Reported Associations of Gene Variants with Non-Syndromic Orofacial Clefts in the Polish Population

Zawiślak,

Woźniak,

Tartaglia

et al. 2024

Biomedicines

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Orofacial clefts (OFCs) are the second most common birth defect worldwide. The etiology of OFCs involves complex interactions between genetics and environment. Advances in genomic technologies have identified gene variants associated with OFCs. This study aimed to investigate whether selected SNPs in the MYH9, MTHFR, MAFB, and SUMO1 genes influence the occurrence of non-syndromic OFCs in the Polish population. The study included 209 individuals with non-syndromic OFCs and 418 healthy controls. Saliva and umbilical cord blood samples were collected for DNA extraction. Four SNPs in the MYH9, MTHFR, MAFB, and SUMO1 genes were genotyped using real-time PCR-based TaqMan assays. Statistical analysis was performed using logistic regression to assess the association between SNPs and OFCs. A significant association was found between the rs7078 CC polymorphism and OFCs (OR = 3.22, CI 1.68–6.17, p < 0.001). No significant associations were identified for the rs1081131, rs13041247, and rs3769817 polymorphisms. The research indicates that the rs7078 polymorphism significantly influences the occurrence of orofacial cleft palate in the Polish population, whereas the rs3769817, rs1801131, and rs13041247 SNPs do not show such a correlation.

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Testing Reported Associations of Gene Variants with Non-Syndromic Orofacial Clefts in the Polish Population

Zawiślak,

Woźniak,

Tartaglia

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes

Cited by 1 publication

References 48 publications

Testing Reported Associations of Gene Variants with Non-Syndromic Orofacial Clefts in the Polish Population

Testing Reported Associations of Gene Variants with Non-Syndromic Orofacial Clefts in the Polish Population

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