Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence

Ji, Yuanyuan; Rui, Su; Tang, Hua; Cui, Jingjing; Deji, Cuola; Shi, Yuhui; Shu-guang, Wei

doi:10.1016/j.neulet.2018.08.023

Cited by 13 publications

(18 citation statements)

References 26 publications

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“…Data synthesis for rs910080 was available on six studies [12][13][14][15][16][17] with seven independent cohorts including 3092 cases and 3136 controls. Due to considerable heterogeneity, random-effect model was employed with the exception of heterozygous model.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…As for rs1997794, four studies [12,13,15,18] with five cohorts involving 2942 cases and 2605 controls went into final data synthesis. Because heterogeneity between studies was significant, the random-effect model was applied.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…Another 4 ineligible articles were erased after comprehensive assessment according to inclusion and exclusion criteria. Ultimately, 7 articles [12][13][14][15][16][17][18] were included in qualitative synthesis and meta-analysis. The process was displayed in Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…A total of seven case-control studies [12][13][14][15][16][17][18] with 3129 cases and 3289 controls were included in the meta-analysis. Of the included studies, six [12][13][14][15][16]18] were published in English and one [17] was in Chinese. It should be noted that Clarke et al's study [15] published in 2012 consisted of two different cohorts.…”

Section: Main Characteristicsmentioning

confidence: 99%

“…Since Zimprich et al [11] initially reported the correlation between PDYN gene polymorphisms and OD, several researchers have subsequently replicated with inconsistent results [12][13][14][15][16][17][18]. The lack of convergent findings might ascribe to weak statistical power to ascertain a significant effect, population structure or betweenstudy heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

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Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

Wang¹,

Ma²,

Lu³

et al. 2019

BMC Psychiatry

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Background: Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility. Methods: Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software. Results: A total of seven case-control studies with 3129 cases and 3289 controls were recruited in the metaanalysis. For rs910080, rs1997794, rs1022563, and rs2235749 polymorphisms of PDYN gene, there were six, four, five, and four studies eventually included, respectively. The findings indicated that rs910080 polymorphism was significantly correlated with OD among Asian population under allelic model (A vs. G, OR = 1.30, 95% CI 1.04-1.62, P = 0.02, FDR = 0.05) and dominant model (AA+AG vs. GG, OR = 1.25, 95% CI 1.04-1.51, P = 0.02, FDR = 0.05). However, rs1022563, rs1997794 and rs2235749 polymorphisms did not appear to associate with OD susceptibility. Conclusions: There existed a significant association between rs1022563 polymorphism and OD among Asian population. As the included studies were not adequate to guarantee a robust and convincing conclusion, future studies with larger sample size among more ethnicities are recommended.

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