Genetic Aspects of Stroke: Human and Experimental Studies

Carr, Fiona; McBride, Martin W.; Carswell, Hilary V O; Graham, Delyth; Strahorn, Pamela; Clark, James S.; Charchar, Fadi J.; Dominiczak, Anna F.

doi:10.1097/00004647-200207000-00001

Cited by 34 publications

(29 citation statements)

References 87 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The identification of genetic components of stroke and neurodegenerative disease linked to TBI is critical to the understanding, diagnosis, and treatment of these injuries (Carr et al, 2002;Longhi et al, 2001). While risk and environmental factors can be identified and controlled, genetic determinants of disease, in addition to conferring an enhanced vulnerability to other neurodegenerative disorders, pose a challenging problem for investigative studies.…”

Section: Genetic Aspects Of Stroke and Head Traumamentioning

confidence: 99%

“…Also, genetically engineered mice that typically over-express or have a specific gene deleted (knock-out) have been developed to study the cause-and-effect relationships in specific injury pathways (Chan et al, 1995). These include the use of mice targeting antioxidant processes, adhesion molecules, interleukins, matrix metalloproteases (MMPs), apoptotic genes, and nitric oxide (Carr et al, 2002).…”

Section: Genetic Aspects Of Stroke and Head Traumamentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences

Bramlett

Dietrich

2004

J Cereb Blood Flow Metab

562

358

View full text Add to dashboard Cite

Summary: Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma indicates that similar mechanisms contribute to loss of cellular integrity and tissue destruction. Mechanisms of cell damage include excitotoxicity, oxidative stress, free radical production, apoptosis and inflammation. Genetic and gender factors have also been shown to be important mediators of pathomechanisms present in both injury settings. However, the fact that these injuries arise from different types of primary insults leads to diverse cellular vulnerability patterns as well as a spectrum of injury processes. Blunt head trauma produces shear forces that result in primary membrane damage to neuronal cell bodies, white matter structures and vascular beds as well as secondary injury mechanisms. Severe cerebral ischemic insults lead to metabolic stress, ionic perturbations, and a complex cascade of biochemical and molecular events ultimately causing neuronal death. Similarities in the pathogenesis of these cerebral injuries may indicate that therapeutic strategies protective following ischemia may also be beneficial after trauma. This review summarizes and contrasts injury mechanisms after ischemia and trauma and discusses neuroprotective strategies that target both types of injuries.

show abstract

Section: Genetic Aspects Of Stroke and Head Traumamentioning

confidence: 99%

Section: Genetic Aspects Of Stroke and Head Traumamentioning

confidence: 99%

Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences

Bramlett

Dietrich

2004

J Cereb Blood Flow Metab

562

358

View full text Add to dashboard Cite

show abstract

“…Our findings underline the fact that stroke is a polygenic disorder (20 ). The effects of gene-gene as well as gene-environment interactions on the predisposition to cerebrovascular disease are still under investigation.…”

Section: Discussionmentioning

confidence: 52%

Candidate Genetic Risk Factors of Stroke: Results of a Multilocus Genotyping Assay

Lalouschek

Endler²,

Schillinger

et al. 2007

Clinical Chemistry

View full text Add to dashboard Cite

Background: Epidemiological studies indicate that genetic factors play a role in the risk of stroke, particularly in younger individuals, but the role of single-nucleotide polymorphisms (SNPs) is controversial. We tested the possible association of a number of previously described SNPs with stroke risk. Methods: We investigated the prevalence of 60 polymorphisms located in 35 genes in 450 white patients who suffered an acute stroke or transient ischemic attack before the age of 60 years and in 817 healthy control individuals by a multilocus PCR-based assay. The controls were randomly selected from attendees of a health service program. Genetic variations were detected by hybridization to nylon strips (Roche Molecular Systems) containing detection oligonucleotides for the SNPs. We used P values of <0.05 for confirmatory analysis of the SNPs in the genes for APOE (allele 4), angiotensin converting enzyme, factor V, prothrombin, and methylenetetrahydrofolate reductase. To account for multiple testing we defined a P value of <0.001 as statistically significant for all exploratory tests. The genes represented in the test panel by more than 1 SNP were also evaluated by haplotype analysis. Results: Frequencies of all 60 tested SNPs among patients and controls were very similar. No SNP reached

show abstract

“…Stroke is diffi cult to study from a molecular point of view, because of its gene-environment interactions, genetic and nongenetic heterogeneity, polygenic inheritance with variable penetrance and not least, late age of onset [6]. Candidate genes, stroke susceptibility alleles and their association with stroke pathogeny have been intensely studied in the last few years [7,8,9]. Immunity and infl ammation are key elements of the pathobiology of ischemic stroke [10], several studies have shown that the serum of patients with stroke highlights increased levels of proinfl ammatory cytokines, and therefore support the hypothesis promoting their involvement in the etiopathogenesis of the disease [11,12].…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Petrisor¹,

Popp²,

Cătană³

et al. 2013

Acta Medica Marisiensis

View full text Add to dashboard Cite

Introduction: Stroke is one of the leading causes of death in Romania. Evidence in supporting the role of the pro-infl ammatory cytokine TNFalpha in ischemic pathogenesis is now well established. The aim of the present study is to evaluate the relationship between TNF -308G>A polymorphism and ischemic stroke in a Northern Romanian population group and to determine whether it has an infl uence on the risk of cerebral events. This is a cross-sectional, randomized, case-control study for the evaluation of TNF -308G>A polymorphism alleles frequency among patients with ischemic stroke. Material and method: The study included 108 patients diagnosed with ischemic stroke (neurological and CT scan examination), and 118 healthy unrelated controls. TNF -308G>A genotyping was carried out using PCR-RFLP technique. The amplifi cation of the relevant gene fragment was subjected to restriction enzyme digestion, followed by gel electrophoresis. Results: Molecular analysis did not reveal an increased frequency of GA mutant genotype in the study group compared to the control group (p = 0.879, OR = 0.928, CI = 0.512-1.682). Conclusions:We found no signifi cant differences in distribution of the TNF -308G>A polymorphism between ischemic stroke patients and controls.

show abstract

Genetic Aspects of Stroke: Human and Experimental Studies

Cited by 34 publications

References 87 publications

Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences

Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences

Candidate Genetic Risk Factors of Stroke: Results of a Multilocus Genotyping Assay

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Contact Info

Product

Resources

About