Genetic Aspects of Cannabis Use Disorder

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

“…One burgeoning area for further research is that of genetic and epigenetic components of CUD. The fact that only a subpopulation of chronic cannabis users develop CUD or express CWS strongly suggests genetic predispositions might be at play (Agrawal & Lynskey, 2006;Blecha et al, 2019;Bogdan et al, 2016) / There are relatively few human genetics studies aiming to identify heritable genetic factors linked to CUD, including familial transmission analysis (Gfroerer, 1987), twin studies (Vink et al, 2010), whole genome sequencing (Gizer et al, 2018;Sherva et al, 2016), and genome-wide association studies (Bogdan et al, 2016;Sherva et al, 2016). Clearly, there will be polygenic contributions to CUD and CWS, as is the case for all substance abuse disorders.…”